“…Recently, additional members of the evolutionarily conserved Cys-rich IGFBP/IGFPB-rP superfamily have not only been reported for vertebrates but also for various arthropods such as ticks (Mulenga and Khumthong, 2010), shrimps (Castellanos et al, 2008), crabs (Gai et al, 2010), crayfish , and insects (Alic and Partridge, 2008;Andersen et al, 2000;Honegger et al, 2008). With perlustrin, a first homolog protein to the vertebrate IGFBP family, an N-terminal module was isolated from the shell of the abalone Haliotis laevigata, exhibiting binding of human IGF-I, IGF-II, and bovine insulin (Weiss et al, 2001(Weiss et al, , 2000.…”