Insulin-like growth factor binding protein 7, a member of insulin-like growth factor signal pathway, involved in immune response of small abalone Haliotis diversicolor

Li, Na; Zhang, Ziping; Zhang, Lili; Wang, Shuhong; Zou, Zhihua; Wang, Guodong; Wang, Yilei

doi:10.1016/j.fsi.2012.04.016

Cited by 42 publications

(23 citation statements)

References 37 publications

(52 reference statements)

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“…S2) was employed as template. The latter has been shown to be conserved in other invertebrate IGFBP homologs (35,36) although its function with this respect is yet to be revealed. The final models of the IB and KI domains and of the IG domain were both found to resemble their reference structures with high accuracy and minimal structural variations, as indicated by 0.95 and 0.64 Å root mean square deviation values, respectively.…”

Section: Resultsmentioning

confidence: 99%

A Crayfish Insulin-like-binding Protein

Rosen

Weil

Manor

et al. 2013

Journal of Biological Chemistry

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Background:In Crustacea, a male-specific insulin-like androgenic hormone governs sexual differentiation. Results: A crayfish insulin-like growth factor-binding protein (Cq-IGFBP) was expressed and found to bind the androgenic hormone. Conclusion: Cq-IGFBP is part of the scheme modulating the crustacean androgenic hormone. Significance: Cq-IGFBP is the first IGFBP found that interacts with an insulin-like gender-specific ligand linking early evolution of insulin pathways with gender.

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Section: Resultsmentioning

confidence: 99%

A Crayfish Insulin-like-binding Protein

Rosen

Weil

Manor

et al. 2013

Journal of Biological Chemistry

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“…Moreover, it can bind strongly to insulin as different from other low affinity IGFBP-rPs, suggesting that IGFBP7 has the same special biological functions with other IGFBPs. 32 IGFBP7 has diverse biological functions in many cellular processes such as proliferation, apoptosis, and senescence. 4,5,33 The expression of IGFBP7 is frequently decreased as a consequence of methylation in tumors.…”

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confidence: 99%

Comparison of telomere length and insulin-like growth factor-binding protein 7 promoter methylation between breast cancer tissues and adjacent normal tissues in Turkish women

et al. 2016

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“…IGFBP7 binds strongly to insulin in vertebrates (Li et al, 2012a). Although the IGFBP family has many members in vertebrates, only one member has been identified in crustacean species, until now (Rosen et al, 2013;Li et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

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Song¹,

Xu²,

Zang³

et al. 2018

Turk. J. Fish. Aquat. Sci.

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Androgenic gland hormone has an insulin-like structure and it is the male-specific hormone found in crustaceans. Androgenic gland hormone controls male sexual differentiation and maintains male sexual characteristics. In this study, the full-length cDNA sequence of the androgenic gland hormone gene in Eriocheir sinensis (EsIAG) was cloned. The total length of the EsIAG cDNA was 1,495 bp, encoding 151 amino acids. EsIAG has the typical conserved structure of other reported IAGs but had low sequence similarity with other crustacean IAGs. EsIAG was expressed specifically in the androgenic gland. Insulin-like growth factor binding protein 7 from the Chinese mitten crab E. sinensis (EsIGFBP7) was highly expressed in the male sex-related organs among nine crab tissues. Interactions between EsIAG and EsIGFBP7 were verified using a yeast-two hybrid assay. These results obtained in this study provide basic information about the regulatory mechanism of male sex differentiation in E. sinensis.

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Insulin-like growth factor binding protein 7, a member of insulin-like growth factor signal pathway, involved in immune response of small abalone Haliotis diversicolor

Cited by 42 publications

References 37 publications

A Crayfish Insulin-like-binding Protein

A Crayfish Insulin-like-binding Protein

Comparison of telomere length and insulin-like growth factor-binding protein 7 promoter methylation between breast cancer tissues and adjacent normal tissues in Turkish women

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