Alopecia areata (AA) is a common, non-scaring form of hair loss caused by immune-mediated attack of the hair follicle. As with other immune-mediated diseases, a complex interplay between environment and genetics is thought to lead to the development of AA. Deficiency of micronutrients such as vitamins and minerals may represent a modifiable risk factor associated with development of AA. Given their role in normal hair follicle development and in immune cell function, a growing number of investigations have sought to determine whether serum levels of these nutrients might differ in AA patients, and whether supplementation of these nutrients might represent a therapeutic option for AA. While current treatment often relies on invasive steroid injections or immunomodulating agents with potentially harmful side-effects, therapy by micronutrient supplementation, whether as a primary modality or as adjunctive treatment, could offer a promising low-risk alternative. However, our review highlights a need for further research in this area, given that the current body of literature largely consists of small case-control studies and case-reports which preclude any definite conclusions for a role of micronutrients in AA. In this comprehensive review of the current literature we found that serum vitamin D, zinc, and folate levels tend to be lower in patients with AA as compared to controls. Evidence is conflicting or insufficient to suggest differences in levels of iron, vitamin B12, copper, magnesium, or selenium. A small number of studies suggest that vitamin A levels may modify the disease. Though understanding of the role for micronutrients in AA is growing, definitive clinical recommendations such as routine serum level testing or therapeutic supplementation, call for additional studies in larger populations and with a prospective design.
The social integration of Canada’s new religious minorities is determined more by their racial minority status than by their religious affiliation or degree of religiosity, according to results from Statistics Canada’s 2002 Ethnic Diversity Survey. Interview questions tap life satisfaction, affective ties to Canada, and participation in the wider community. Muslims, Sikhs, Buddhists, and Hindus are slower to integrate socially, mainly because they are mostly racial minorities. Degree of religiosity affects social integration in the same ways as ethnic community attachments in general, positively for some dimensions, negatively for others, and similarly for different religious groups. Patterns are similar in Quebec and the rest of Canada; results carry implications for the debate over “reasonable accommodation” of religious minorities in Quebec, and parallel debates in other provinces and countries.
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