Abstract:Isatis tinctoria L. (Brassicaceae), which is commonly known as woad, is a species with an ancient and well-documented history as an indigo dye and medicinal plant. Currently, I. tinctoria is utilized more often as medicinal remedy and also as a cosmetic ingredient. In 2011, I. tinctoria root was accepted in the official European phytotherapy by introducing its monograph in the European Pharmacopoeia. The biological properties of raw material have been known from Traditional Chinese Medicine (TCM). Over recent … Show more
“…Fabaceae) liquorice root Fabaceae dried root and rhizome Glycyrrhizin, Glycyrrhetinic acid, Glycyrretol Wagner et al (2015a) Glycyrrhizae, uralensis Chinese liquorice Fabaceae Rhizome, root glycyrrhizin Tanemoto et al (2015) Lophatherum gracile Brongn Herba Lophatheri Poaceae Dried stem and leaf Luteolin, isoorientin, isovitexin, swertisin Fan et al (2015) Mentha haplocalyx Briq. Lamiaceae Aerial parts (stem and leaf) spicatoside A, spicatoside B, menthalactone, maniladiol, He et al (2019) Schizonepeta tenuifolia Herba Schizonepetae Saururaceae Leaves and Spikes (−)-menthone, (+)-pulegone, (−)-limonene and (+)-menthofuran ( Schwarz et al, 2011 ; Song et al, 2016 ) Isatis tinctorial L. Woad or dyer's woad Brassicaceae dried root Isatin, Isatan A – B − C, Isoindigo, Isoorientin, Speranza et al (2020) Lonicera japonica Japanese honeysuckle and golden-and-silver honeysuckle Caprifoliaceae Flower bud, roots Stryspinoside, chlorogenic acid, loganin aglycone, caffeic acid ( Wang et al, 2013 ; Yu et al, 2016 ) Pogostemon cablin . (Blanco) Benth.…”
Section: Medicinal Plants For Viral Respiratory Infections (Vri)mentioning
“…Fabaceae) liquorice root Fabaceae dried root and rhizome Glycyrrhizin, Glycyrrhetinic acid, Glycyrretol Wagner et al (2015a) Glycyrrhizae, uralensis Chinese liquorice Fabaceae Rhizome, root glycyrrhizin Tanemoto et al (2015) Lophatherum gracile Brongn Herba Lophatheri Poaceae Dried stem and leaf Luteolin, isoorientin, isovitexin, swertisin Fan et al (2015) Mentha haplocalyx Briq. Lamiaceae Aerial parts (stem and leaf) spicatoside A, spicatoside B, menthalactone, maniladiol, He et al (2019) Schizonepeta tenuifolia Herba Schizonepetae Saururaceae Leaves and Spikes (−)-menthone, (+)-pulegone, (−)-limonene and (+)-menthofuran ( Schwarz et al, 2011 ; Song et al, 2016 ) Isatis tinctorial L. Woad or dyer's woad Brassicaceae dried root Isatin, Isatan A – B − C, Isoindigo, Isoorientin, Speranza et al (2020) Lonicera japonica Japanese honeysuckle and golden-and-silver honeysuckle Caprifoliaceae Flower bud, roots Stryspinoside, chlorogenic acid, loganin aglycone, caffeic acid ( Wang et al, 2013 ; Yu et al, 2016 ) Pogostemon cablin . (Blanco) Benth.…”
Section: Medicinal Plants For Viral Respiratory Infections (Vri)mentioning
“…Therefore, traditional herbs from diverse geographical locations and various habitats could be considered as potential sources of new drugs for treatment of viral infections, including those caused by SARS-CoVs and its emergent mutants. For centuries, the medicinal plant Isatis tinctoria L. (Brassicaceae) have been esteemed in Europe, Central Asia, and in TCM for therapeutic and cosmetic application, and indigo-blue dyeing character ( Speranza et al, 2020 ). All parts of this plant are utilized in complementary and alternative medicinal preparations against eruptive epidemic diseases, pharyngitis, laryngitis, hepatitis, various kinds of fevers, influenza and viral skin diseases.…”
Section: Plants With Inhibitory Activity Against 3cl Proteasementioning
Background: The ongoing COVID-19 pandemic has created an alarming situation due to extensive loss of human lives and economy, posing enormous threat to global health security. Till date, no antiviral drug or vaccine against SARS-CoV-2 has reached the market, although a number of clinical trials are under way. The viral 3-chymotrypsin-like cysteine protease (3CLpro), playing pivotal roles in coronavirus replication and polyprotein processing, is essential for its life cycle. In fact, 3CLpro is already a proven drug discovery target for SARS- and MERS-CoVs. This underlines the importance of 3CL protease in the design of potent drugs against COVID-19.Methods: We have collected one hundred twenty-seven relevant literatures to prepare the review article. PubMed, Google Scholar and other scientific search engines were used to collect the literature based on keywords, like “SARS-CoVs-3CL protease,” “medicinal plant and anti-SARS-CoVs-3CL protease” published during 2003–2020. However, earlier publications related to this topic are also cited for necessary illustration and discussion. Repetitive articles and non-English studies were excluded.Results: From the literature search, we have enlisted medicinal plants reported to inhibit coronavirus 3CL protease. Some of the plants like Isatis tinctoria L. (syn. Isatis indigotica Fort.), Torreya nucifera (L.) Siebold and Zucc., Psoralea corylifolia L., and Rheum palmatum L. have exhibited strong anti-3CLpro activity. We have also discussed about the phytochemicals with encouraging antiviral activity, such as, bavachinin, psoralidin, betulinic acid, curcumin and hinokinin, isolated from traditional medicinal plants.Conclusion: Currently, searching for a plant-derived novel drug with better therapeutic index is highly desirable due to lack of specific treatment for SARS-CoV-2. It is expected that in-depth evaluation of medicinally important plants would reveal new molecules with significant potential to inhibit coronavirus 3CL protease for development into approved antiviral drug against COVID-19 in future.
“…Isatis tinctoria also known as Isatis indigotica, woad or Ban Lan Gen (Family: Brassicaceae) are herbaceous plants native to Central Asia, South-eastern Russia and South-eastern Europe (Speranza et al 2020). This anti-inflammatory plant is widely utilized in traditional Chinese medicine, as cosmetics raw material production and food in Europe (Speranza et al 2020).…”
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