Therapeutic potential of medicinal plants against COVID-19: The role of antiviral medicinal metabolites

Khan, Tariq A.; Khan, Mubarak Ali; Mashwani, Zia‐ur‐Rehman; Ullah, Najeeb; Nadhman, Akhtar

doi:10.1016/j.bcab.2020.101890

Cited by 81 publications

(50 citation statements)

References 134 publications

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“…In vitro cultures of plants provide a model platform for studying their potential as factories for important medicinal compounds. In vitro cultures, including plant cell and callus cultures, can serve as factories of phytochemicals/secondary metabolites that can be produced in uniform quality to fight against many threatening diseases, including infectious diseases such as the currently pandemic COVID-19 (Khan et al 2020b ). The in vitro culture-based production of phytochemicals has an additional benefit of consistency in yield and quality (Khan et al 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Iron-doped zinc oxide nanoparticles-triggered elicitation of important phenolic compounds in cell cultures of Fagonia indica

Khan

et al. 2021

Plant Cell Tiss Organ Cult

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The callus cultures of Fagonia indica could prove as factories for the production of important phytochemicals when triggered through different types of stress. In this study, we initiated callus cultures from healthy stem explants in the presence of iron-doped zinc oxide nanoparticles (Fe-ZnO-NPs). We performed experiments with the callus cultures of F. indica to determine the impact of Fe-ZnO-NPs in concentrations (15.62–250 µg/mL) on biomass accumulation, production of important phenolic and flavonoids, and antioxidative potential. Our results showed that maximum callus biomass [Fresh weight (FW) = 13.6 g and Dry weight (DW) = 0.58 ± 0.01] was produced on day 40 when the media was supplemented with 250 μg/mL Fe-ZnO-NPs. Similarly, maximum total phenolic content (268.36 μg GAE/g of DW) was observed in 40 days old callus added with 125 μg/mL Fe-ZnO-NPs. Maximum total flavonoid content (78.56 μg QE/g of DW) was recorded in 20 days old callus grown in 62.5 μg/mL Fe-ZnO-NPs containing media. Maximum total antioxidant capacity (390.74 µg AAE/g of DW) was recorded in 40 days old callus with 125 μg/mL Fe-ZnO-NPs treated cultures, respectively. Similarly, the highest free radical scavenging activity (93.02%) was observed in callus derived from media having 15.62 µg/mL Fe-ZnO-NPs. The antioxidant potential was observed to have positive correlation with TPC (r = 0.44). HPLC analysis showed that Fe-ZnO-NPs produced compounds (e.g., Epigallocatechin gallate) that were either absent or in lesser quantities in the control group. These results showed that Fe-ZnO-NPs elicitors could increase the biomass and activate secondary metabolism in F. indica cells. Supplementary Information The online version contains supplementary material available at 10.1007/s11240-021-02123-1.

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Section: Introductionmentioning

confidence: 99%

Iron-doped zinc oxide nanoparticles-triggered elicitation of important phenolic compounds in cell cultures of Fagonia indica

Khan

et al. 2021

Plant Cell Tiss Organ Cult

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“…Lifestyle interventions, such as following a healthy diet, getting adequate rest, and performing physical activity, might additionally support maintaining a healthy immune system, which is crucial for a proper response against SARS-CoV-2 infection, reducing the risk of severe COVID-19 and hospitalization [ 162 , 163 , 164 ]. In the same manner, research on additional therapeutic agents, such as immunotherapy [ 165 ] or plant-derived compounds [ 166 ], could equally provide potential tools for the clinical management of severe COVID-19 patients, as it is necessary to approach this pandemic from an integrative perspective.…”

Section: Discussionmentioning

confidence: 99%

An Updated Review of SARS-CoV-2 Vaccines and the Importance of Effective Vaccination Programs in Pandemic Times

et al. 2021

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Since the worldwide COVID-19 pandemic was declared a year ago, the search for vaccines has become the top priority in order to restore normalcy after 2.5 million deaths worldwide, overloaded sanitary systems, and a huge economic burden. Vaccine development has represented a step towards the desired herd immunity in a short period of time, owing to a high level of investment, the focus of researchers, and the urge for the authorization of the faster administration of vaccines. Nevertheless, this objective may only be achieved by pursuing effective strategies and policies in various countries worldwide. In the present review, some aspects involved in accomplishing a successful vaccination program are addressed, in addition to the importance of vaccination in a pandemic in the face of unwillingness, conspiracy theories, or a lack of information among the public. Moreover, we provide some updated points related to the landscape of the clinical development of vaccine candidates, specifically, the top five vaccines that are already being assessed in Phase IV clinical trials (BNT162b2, mRNA-1273, AZD1222, Ad26.COV2.S, and CoronaVac).

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“…It was caused by SARS-CoV-2 virus (21). The plants can produce many important chemical components through their secondary metabolism, that operates as a self-defense against the stress induced by the environmental triggers and pathogens (9). In this situation, preventive and therapeutic agents have not been established and recommended, globally the use of medicinal plants is advised to prevent the COVID -19 (79).…”

Section: History Of Use Of Medicinal Plants and Spicesmentioning

confidence: 99%

A review: Antimicrobial activity of the medicinal spice plants to cure human disease

et al. 2021

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Since the ancient time medicinal plants and spices are used as herbal medicine because of their medicinal values. They are the valuable resources of the natural antimicrobial compounds used to treat the infectious disease caused by bacteria and other pathogens. Plant’s extract, essential oil and numerous kinds of secondary compounds had antibacterial, antiviral, antifungal and antioxidants activities with less or no toxic effects; that are essential to cure many diseases. The compounds isolated from the medicinal spice plants show antimicrobial activity against some bacterial strains that has the ability to affect the food quality and shelf life of the food. These plants have various medicinal properties like anti-inflammatory action, tonic, expectorants, diuretics, astringents, digestives, carminative, antibiotics and stimulants etc. The spectrum of compounds present in medicinal spice plants, and the structure of major compounds discussed in this review, are responsible for all of their medicinal properties. Therefore, plants are used in the form of maceration, fluid extracts, oil, syrup, juice, decoction, powder, tea and ointments. In the terms of the frequencies and configuration of various radicals both medicinal plants and antibiotics are different. Since plant-based products have no toxicity, also less costly than conventional drugs, research on the compounds found in medicinal plants and their action against harmful microbial species should be conducted in order to improve human health and expand the use of medicinal plants. Plants also have the ability to inhibit or alter protein-protein interactions, making them a powerful modulator of signal transduction, apoptosis, mitosis and immune response.

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Therapeutic potential of medicinal plants against COVID-19: The role of antiviral medicinal metabolites

Cited by 81 publications

References 134 publications

Iron-doped zinc oxide nanoparticles-triggered elicitation of important phenolic compounds in cell cultures of Fagonia indica

Iron-doped zinc oxide nanoparticles-triggered elicitation of important phenolic compounds in cell cultures of Fagonia indica

An Updated Review of SARS-CoV-2 Vaccines and the Importance of Effective Vaccination Programs in Pandemic Times

A review: Antimicrobial activity of the medicinal spice plants to cure human disease

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