Recent insights on anti-dengue virus (DENV) medicinal plants: review on in vitro, in vivo and in silico discoveries

Lim, Sharoen Yu Ming; Chieng, Jin Yu; Pan, Yan

doi:10.1080/26895293.2020.1856192

Cited by 33 publications

(25 citation statements)

References 129 publications

(197 reference statements)

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“…Since, the small molecule/drug candidates did not perform as desired in clinical trials 63 , scientists turned towards natural products, phytochemicals, for finding therapeutic agents against dengue. More than 70 medicinal plants have been identified so far, which show anti DENV activity, effected through extracts and their purified compounds 25 .…”

Section: Discussionmentioning

confidence: 99%

“…Chebulinic acid was originally isolated from the flower extract of the plant Terminalia chebula , a medicinal plant that belongs to the Combretaceae family and is one of the most documented plants in the ancient Indian Ayurvedic system of medicine 25 , 26 . Fruit and flower extracts have shown broad inhibitory activity against viruses such as swine influenza A virus 27 , Hepatitis B 28 , Hepatitis C 29 , HSV-1 30 , HSV-2 31 , HIV 32 , and cytomegalovirus 33 .…”

Section: Introductionmentioning

confidence: 99%

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Studies on the antiviral activity of chebulinic acid against dengue and chikungunya viruses and in silico investigation of its mechanism of inhibition

Thomas

Patil

Sharma

et al. 2022

Sci Rep

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Chebulinic acid (CA), originally isolated from the flower extract of the plant Terminalia chebula, has been shown to inhibit infection of herpes simplex virus-2 (HSV-2), suggestively by inhibiting the host entry step of viral infection. Like HSV-2, the dengue virus (DENV) and chikungunya virus (CHIKV) also use receptor glycosaminoglycans (GAG) to gain host entry, therefore, the activity of CA was tested against these viruses. Co-treatment of 8 µM CA with DENV-2 caused 2 log decrease in the virus titer (4.0 log10FFU/mL) at 120 h post infection, compared to virus control (5.95 log10FFU/mL). In contrast, no inhibitory effect of CA was observed against CHIKV infection under any condition. The mechanism of action of CA was investigated in silico by employing DENV-2 and CHIKV envelope glycoproteins. During docking, CA demonstrated equivalent binding at multiple sites on DENV-2 envelope protein, including GAG binding site, which have previously been reported to play a crucial role in host attachment and fusion, indicating blocking of these sites. However, CA did not show binding to the GAG binding site on envelope protein-2 of CHIKV. The in vitro and in silico findings suggest that CA possesses the ability to inhibit DENV-2 infection at the entry stage of its infection cycle and may be developed as a potential therapeutic agent against it.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Studies on the antiviral activity of chebulinic acid against dengue and chikungunya viruses and in silico investigation of its mechanism of inhibition

Thomas

Patil

Sharma

et al. 2022

Sci Rep

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“…Luteolin was reported to be an uncompetitive inhibitor of the host proprotein convertase furin, which is an endoprotease significant in DENV maturation in the trans-Golgi compartment [ 144 ]. Apart from the specific bioactive compounds, many of the medicinal plants, such as Acacia catechu , Acorus calamus , Allium sativum , Azadarachta indica , Cissampelos pareira , Cymbopogon citratus , Ficus septica , Kaempferia parviflora , Myristica fatua , Pavetta tomentosa , and many more compiled by Lim et al, 2021, showed anti-DENV effects and await research pertaining to their mechanism of action for the development of efficient therapeutics against the DENV [ 145 ].…”

Section: Antivirals Against Dengue Infectionmentioning

confidence: 99%

Dengue Virus Infection: A Tale of Viral Exploitations and Host Responses

Nanaware

Banerjee

Bagchi

et al. 2021

Viruses

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Dengue is a mosquito-borne viral disease (arboviral) caused by the Dengue virus. It is one of the prominent public health problems in tropical and subtropical regions with no effective vaccines. Every year around 400 million people get infected by the Dengue virus, with a mortality rate of about 20% among the patients with severe dengue. The Dengue virus belongs to the Flaviviridae family, and it is an enveloped virus with positive-sense single-stranded RNA as the genetic material. Studies of the infection cycle of this virus revealed potential host targets important for the virus replication cycle. Here in this review article, we will be discussing different stages of the Dengue virus infection cycle inside mammalian host cells and how host proteins are exploited by the virus in the course of infection as well as how the host counteracts the virus by eliciting different antiviral responses.

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“…Different parts of this plant extracts were reported with antidiarrheal [37], antihyperglycemic [19,30,[38][39][40], antimicrobial [21], anti-inflammatory [41], antipyretic [42], antioxidant [43,44], antiulcer [45], hepatoprotective [27,46], and immunomodulatory [17] activity. Additionally, Acacia species extracts also show antiviral activity against dengue virus [47,48], human immunodeficiency virus (HIV) [49,50], herpes simplex virus [49], and hepatitis B and C virus [51,52]. Different phytochemicals present in plant extract are responsible for the diverse bioactivities (Figure 1).…”

Section: Chemical Composition and Pharmacological Applicationsmentioning

confidence: 99%

A Comprehensive Review on the Chemical Composition and Pharmacological Activities of Acacia catechu (L.f.) Willd.

Adhikari

Aryal

Bhattarai

2021

Journal of Chemistry

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With the emergence of epidemics, pandemics, and infectious diseases, several research activities have been carried out on natural products to tackle them. As there are structural diversities in natural products, researchers are focused on exploring them for treatment and/or management of various infections and/or diseases. Acacia catechu (L.f.) Willd. belonging to the order Fabales and family Fabaceae shows a wide range of pharmacological functions in the management of diseases in humankind. This review was carried out to gather and provide information about the chemical constituents and pharmacological activities of A. catechu through the literature survey of scientific articles. On preliminary assessments, A. catechu is demonstrated as a significant wellspring of bioactive compounds with a wide range of biological and pharmaceutical applications such as antidiabetic, antioxidant, antimicrobial, anticancer, antidiarrheal, anti-inflammatory, antiviral, hepatoprotective, immunomodulatory, and so on. Although the metabolites from the plant are reported with diverse pharmacological applications, there is little information in regards to toxicity and clinical trials on bioactive compounds of this plant. Further research on diverse bioactive compounds from the plant is required to develop them as a successful potent drug.

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Recent insights on anti-dengue virus (DENV) medicinal plants: review on in vitro, in vivo and in silico discoveries

Cited by 33 publications

References 129 publications

Studies on the antiviral activity of chebulinic acid against dengue and chikungunya viruses and in silico investigation of its mechanism of inhibition

Studies on the antiviral activity of chebulinic acid against dengue and chikungunya viruses and in silico investigation of its mechanism of inhibition

Dengue Virus Infection: A Tale of Viral Exploitations and Host Responses

A Comprehensive Review on the Chemical Composition and Pharmacological Activities of Acacia catechu (L.f.) Willd.

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