Dengue Virus Infection: A Tale of Viral Exploitations and Host Responses

Nanaware, Nikita; Banerjee, Anwesha; Bagchi, Satarupa Mullick; Bagchi, Parikshit; Mukherjee, Anupam

doi:10.3390/v13101967

Cited by 49 publications

(47 citation statements)

References 145 publications

(185 reference statements)

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“…The role of the different FcɣRs and immune cells in protection from viral or parasitic diseases is not fully established, also because establishing suitable models is particularly challenging. Nonetheless FcɣRs as well monocytes and macrophages have been implicated as important effectors in controlling viral diseases caused by Influenza A virus, SARS-CoV and SARS-CoV-2 viruses, Chikunguya virus, West Nile virus and Yellow Fever virus ( 166 , 170 , 172 , 174 ). Less frequently a role of NK cells or NKT cells has been demonstrated ( 166 ).…”

Section: Modulation Of Igg Fucosylation In Physiological States and D...mentioning

confidence: 99%

Role of Fc Core Fucosylation in the Effector Function of IgG1 Antibodies

2022

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The presence of fucose on IgG1 Asn-297 N-linked glycan is the modification of the human IgG1 Fc structure with the most significant impact on FcɣRIII affinity. It also significantly enhances the efficacy of antibody dependent cellular cytotoxicity (ADCC) by natural killer (NK) cells in vitro, induced by IgG1 therapeutic monoclonal antibodies (mAbs). The effect of afucosylation on ADCC or antibody dependent phagocytosis (ADCP) mediated by macrophages or polymorphonuclear neutrophils (PMN) is less clear. Evidence for enhanced efficacy of afucosylated therapeutic mAbs in vivo has also been reported. This has led to the development of several therapeutic antibodies with low Fc core fucose to treat cancer and inflammatory diseases, seven of which have already been approved for clinical use. More recently, the regulation of IgG Fc core fucosylation has been shown to take place naturally during the B-cell immune response: A decrease in α-1,6 fucose has been observed in polyclonal, antigen-specific IgG1 antibodies which are generated during alloimmunization of pregnant women by fetal erythrocyte or platelet antigens and following infection by some enveloped viruses and parasites. Low IgG1 Fc core fucose on antigen-specific polyclonal IgG1 has been linked to disease severity in several cases, such as SARS-CoV 2 and Dengue virus infection and during alloimmunization, highlighting the in vivo significance of this phenomenon. This review aims to summarize the current knowledge about human IgG1 Fc core fucosylation and its regulation and function in vivo, in the context of both therapeutic antibodies and the natural immune response. The parallels in these two areas are informative about the mechanisms and in vivo effects of Fc core fucosylation, and may allow to further exploit the desired properties of this modification in different clinical contexts.

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Section: Modulation Of Igg Fucosylation In Physiological States and D...mentioning

confidence: 99%

Role of Fc Core Fucosylation in the Effector Function of IgG1 Antibodies

2022

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“…Dengue fever symptoms include nausea, vomiting, and fever. Severe Dengue disease is characterized by severe headache, retro-orbital and muscle pain, joint and bone pain, macular or maculopapular rash, and minor hemorrhagic manifestations [71].…”

Section: Dengue Virusesmentioning

confidence: 99%

γδ T Cells in Emerging Viral Infection: An Overview

Cimini

Agrati

2022

Viruses

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New emerging viruses belonging to the Coronaviridae, Flaviviridae, and Filoviridae families are serious threats to public health and represent a global concern. The surveillance to monitor the emergence of new viruses and their transmission is an important target for public health authorities. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is an excellent example of a pathogen able to cause a pandemic. In a few months, SARS-CoV-2 has spread globally from China, and it has become a world health problem. Gammadelta (γδ) T cell are sentinels of innate immunity and are able to protect the host from viral infections. They enrich many tissues, such as the skin, intestines, and lungs where they can sense and fight the microbes, thus contributing to the protective immune response. γδ T cells perform their direct antiviral activity by cytolytic and non-cytolytic mechanisms against a wide range of viruses, and they are able to orchestrate the cellular interplay between innate and acquired immunity. For their pleiotropic features, γδ T cells have been proposed as a target for immunotherapies in both cancer and viral infections. In this review, we analyzed the role of γδ T cells in emerging viral infections to define the profile of the response and to better depict their role in the host protection.

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“…DENV after receptor-mediated endocytosis, virion fuses with acidic lysosomes, and its genomic RNA is released into the cytoplasm and translated into a polyprotein of ~3400 amino acids (genome is about 11000 bases of positive-sense, a single-stranded RNA (ssRNA)) that are further cleaved by viral and host proteases into three structural (capsid: C, membrane: M, and envelope: E) and seven nonstructural (NS1, NS2A, NS2B, NS3, NS4A, NS4B and NS5) proteins [ 60 ].…”

Section: Denv Infectionmentioning

confidence: 99%

Production, Transmission, Pathogenesis, and Control of Dengue Virus: A Literature-Based Undivided Perspective

Islam

Quispe

Herrera‐Bravo

et al. 2021

BioMed Research International

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Dengue remains one of the most serious and widespread mosquito-borne viral infections in human beings, with serious health problems or even death. About 50 to 100 million people are newly infected annually, with almost 2.5 billion people living at risk and resulting in 20,000 deaths. Dengue virus infection is especially transmitted through bites of Aedes mosquitos, hugely spread in tropical and subtropical environments, mostly found in urban and semiurban areas. Unfortunately, there is no particular therapeutic approach, but prevention, adequate consciousness, detection at earlier stage of viral infection, and appropriate medical care can lower the fatality rates. This review offers a comprehensive view of production, transmission, pathogenesis, and control measures of the dengue virus and its vectors.

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Dengue Virus Infection: A Tale of Viral Exploitations and Host Responses

Cited by 49 publications

References 145 publications

Role of Fc Core Fucosylation in the Effector Function of IgG1 Antibodies

Role of Fc Core Fucosylation in the Effector Function of IgG1 Antibodies

γδ T Cells in Emerging Viral Infection: An Overview

Production, Transmission, Pathogenesis, and Control of Dengue Virus: A Literature-Based Undivided Perspective

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