Is there a role for herbal medicine in the treatment and management of periodontal disease?

Milovanova-Palmer, Julija; Pendry, Barbara

doi:10.1016/j.hermed.2018.02.004

Cited by 16 publications

(21 citation statements)

References 64 publications

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“…On the other hand, the fact that the concentration of 1 μM was not different from peroxide, suggests that the maintenance of the cellular viability promoted by piceatannol does not depend on the action of GSH and probably another antioxidant route. Herbal extracts from natural products are considered potential candidates for the treatment of chronic periodontitis, substantially increasing the number of in vitro and in vivo studies related to the efficacy of medicinal plants with known anti-inflammatory and antibacterial actions [55,56]. In our study, the effects of piceatannol on hPLF under mimetic effect of inflammatory conditions was concentration-dependent.…”

Section: Resultsmentioning

confidence: 61%

Piceatannol Increases Antioxidant Defense and Reduces Cell Death in Human Periodontal Ligament Fibroblast under Oxidative Stress

et al. 2019

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Piceatannol is a resveratrol metabolite that is considered a potent antioxidant and cytoprotector because of its high capacity to chelate/sequester reactive oxygen species. In pathogenesis of periodontal diseases, the imbalance of reactive oxygen species is closely related to the disorder in the cells and may cause changes in cellular metabolism and mitochondrial activity, which is implicated in oxidative stress status or even in cell death. In this way, this study aimed to evaluate piceatannol as cytoprotector in culture of human periodontal ligament fibroblasts through in vitro analyses of cell viability and oxidative stress parameters after oxidative stress induced as an injury simulator. Fibroblasts were seeded and divided into the following study groups: control, vehicle, control piceatannol, H2O2 exposure, and H2O2 exposure combined with the maintenance in piceatannol ranging from 0.1 to 20 μM. The parameters analyzed following exposure were cell viability by trypan blue exclusion test, general metabolism status by the 3-[4,5-dimethylthiazole-2-yl]-2,5-diphenyltetrazolium bromide (MTT) method, mitochondrial activity through the ATP production, total antioxidant capacity, and reduced gluthatione. Piceatannol was shown to be cytoprotective due the maintenance of cell viability between 1 and 10 μM even in the presence of H2O2. In a concentration of 0.1 μM piceatannol decreased significantly cell viability but increased cellular metabolism and antioxidant capacity of the fibroblasts. On the other hand, the fibroblasts treated with piceatannol at 1 μM presented low metabolism and antioxidant capacity. However, piceatannol did not protect cells from mitochondrial damage as measured by ATP production. In summary, piceatannol is a potent antioxidant in low concentrations with cytoprotective capacity, but it does not prevent all damage caused by hydrogen peroxide.

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Section: Resultsmentioning

confidence: 61%

Piceatannol Increases Antioxidant Defense and Reduces Cell Death in Human Periodontal Ligament Fibroblast under Oxidative Stress

et al. 2019

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“…Regarding secondary metabolites Palombo et al, Viera et al, Milonova et al, among others, have directly associated plant extracts and fractions antimicrobial activity against oral cavity bacteria with secondary metabolite content, such as phenols, polyphenols, flavonoids, terpenes and alkaloids, among others [28,120,121].…”

Section: Anticariogenic and Antiperiodontal Activitiesmentioning

confidence: 99%

“…Various studies with plant extracts and secondary metabolites report high antimicrobial activity. As a case in point, macelignan obtained from Myristica fragrans acts against Streptococcus mutans [27][28][29]. Moreover, antibacterial activity was evidenced with bakuchiol (obtained from Psoralea coryfolia) against Streptococcus mutans, Streptocccus sanguis, Streptococcus salivarus, Streptococcus sobrinus, and Lactobacillus acidophilus [30].…”

Section: Introductionmentioning

confidence: 97%

Preliminary Phytochemical Analysis of Berberis goudotii Triana & Planch. ex Wedd. (Berberidaceae) with Anticariogenic and Antiperiodontal Activities

et al. 2019

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Berberis goudotii is an endemic Colombian plant found in the paramo ecosystem. It has been used in food preparation and as a medicinal plant for diverse treatments. Additionally, it is used as a mouthwash to strengthen the gums and combat throat irritations and periodontitis. The present research evaluated Berberis goudotii aerial parts extract and fractions antimicrobial activities. Ultrasonic-assisted extraction was used to attain total ethanol-water extract. Solid-liquid fractionation was used to obtain hexane fraction. The residue was dispersed in water and liquid-liquid fractionation was carried-out to acquire dichloromethane, butanol and water fractions. Preliminary phytochemical analysis was performed on total extract and phenol, polyphenol, flavonoid, and proanthocyanidin, while tannin content was quantified. Antimicrobial activity assessment was performed by agar diffusion method using disks and wells employing Ceftazidime as a positive control against Streptococcus mutans, Streptococcus sobrinus, Lactobacillus acidophilus, Lactobacillus casei, Porphyromonas gingivalis, Prevotella intermedia and Fusobacterium nucleatum. Antimicrobial activity was determined as relative percentage inhibition (RPI), minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). Phenols (92.5 ± 7.7 mg GA/10 g), polyphenols (87.7 ± 8.1 mg PG/10 g) and tannins (44.1 ± 4.3 mg PG/10 g) were among the highest secondary metabolites observed. Total extract presented an MBC of 1.0 µg/µL against cariogenic bacteria (Streptococcus mutans and Streptococcus sobrinus) and 0.12 µg/µL against bacteria associated with periodontal disease (Porphyromonas gingivalis, Prevotella intermedia and Fusobacterium nucleatum). Butanol and hexane fractions showed antiperiodontal activity with MBC of 0.12 and 1.0 µg/µL, respectively. In conclusion, Berberis goudotii total extract demonstrated antimicrobial activity against cariogenic and periodontal microorganisms, on the other hand, hexane and butanol fractions displayed antiperiodontal activity.

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“…The microbial composition differs between supragingival and subgingival (periodontopathogenic) dental plaque. Supragingival plaque or cariogenic plaque is colonized with facultative anaerobic bacteria, such as Streptococcus spp or Actynomices spp [ 75 ].…”

Section: Bioactivity—oral Cavity Conditions As Targets Of Phenolicmentioning

confidence: 99%

Research Advances in the Use of Bioactive Compounds from Vitis vinifera By-Products in Oral Care

et al. 2020

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Oral health is considered an important factor of general health and it contributes to the quality of life. Despite the raising awareness of preventive measures, the prevalence of oral health conditions continues to increase. In this context, a growing interest in investigating natural resources like Vitis vinifera (V. vinifera) phenolic compounds (PhCs) as oral health promoters has emerged. This paper aims to review the evidence about the bioactivities of V. vinifera by-products in oral health. Up to date, a high number of studies have thoroughly reported the antimicrobial and antiplaque activity of V. vinifera extracts against S. mutans or in multi-species biofilms. Moreover, the bioactive compounds from V. vinifera by-products have been shown to modulate the periodontal inflammatory response and the underlying oxidative stress imbalance induced by the pathogenic bacteria. Considering these beneficial effects, the utility of V. vinifera by-products in the maintaining of oral health and the necessary steps towards the development of oral care products were emphasized. In conclusion, the high potential of V. vinifera by-products could be valorized in the development of oral hygiene products with multi-target actions in the prevention and progression of several oral conditions.

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Is there a role for herbal medicine in the treatment and management of periodontal disease?

Cited by 16 publications

References 64 publications

Piceatannol Increases Antioxidant Defense and Reduces Cell Death in Human Periodontal Ligament Fibroblast under Oxidative Stress

Piceatannol Increases Antioxidant Defense and Reduces Cell Death in Human Periodontal Ligament Fibroblast under Oxidative Stress

Preliminary Phytochemical Analysis of Berberis goudotii Triana & Planch. ex Wedd. (Berberidaceae) with Anticariogenic and Antiperiodontal Activities

Research Advances in the Use of Bioactive Compounds from Vitis vinifera By-Products in Oral Care

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