Research Advances in the Use of Bioactive Compounds from Vitis vinifera By-Products in Oral Care

Abstract

Oral health is considered an important factor of general health and it contributes to the quality of life. Despite the raising awareness of preventive measures, the prevalence of oral health conditions continues to increase. In this context, a growing interest in investigating natural resources like Vitis vinifera (V. vinifera) phenolic compounds (PhCs) as oral health promoters has emerged. This paper aims to review the evidence about the bioactivities of V. vinifera by-products in oral health. Up to date, a high number of studies have thoroughly reported the antimicrobial and antiplaque activity of V. vinifera extracts against S. mutans or in multi-species biofilms. Moreover, the bioactive compounds from V. vinifera by-products have been shown to modulate the periodontal inflammatory response and the underlying oxidative stress imbalance induced by the pathogenic bacteria. Considering these beneficial effects, the utility of V. vinifera by-products in the maintaining of oral health and the necessary steps towards the development of oral care products were emphasized. In conclusion, the high potential of V. vinifera by-products could be valorized in the development of oral hygiene products with multi-target actions in the prevention and progression of several oral conditions.

Grape Stem Extracts with Potential Anticancer and Antioxidant Properties

“…On the other hand, grape stem extracts have significant antimicrobial activities that seem to be influenced by the structure and function of phenolic compounds, as well as by their interspecific relation with different bacterial strains [ 19 , 20 ]. For example, these types of extracts inhibited the growth of both Gram-positive ( Listeria monocytogenes , Staphylococcus aureus and Enterococcus faecalis ) and Gram-negative (Pseudomonas aeruginosa , Escherichia coli and Klebsiella pneumoniae ) digestive pathogens under in vitro conditions [ 21 ], and their bioactive compounds are used in oral care [ 22 ].…”

Phytochemical Properties and In Vitro Biological Activities of Phenolic Compounds from Flower of Clitoria ternatea L.

“…Phenolic compounds, existing in many kinds of plants, can be classified into two main groups: simple phenols and polyphenols [ 1 ]. The simple phenol group includes phenolic acids, while polyphenols include flavonoids (flavonols, flavanols, flavones, isoflavones), and lignans.…”

Anti-Inflammatory and Antioxidant Properties of Plant Extracts

“…In this way, natural extracts from Pinus pinaster bark, rich in phenols, showed potent antibacterial activity against Gram-positive bacteria [14]. Likewise, a review by Bogdan et al shows the antimicrobial activity of Vitis vinifera by-products and their application in oral care [15].…”