Irritability of the skin barrier: A comparison of chronologically aged and photo-aged skin in elderly and young adults

Blaak, Jürgen; Lüttje, Dieter; John, Swen Malte; Schürer, Nanna

doi:10.1016/j.eurger.2011.05.011

Cited by 19 publications

(16 citation statements)

References 36 publications

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“…Besides a reduced integrity, the SC recovery rate is also significantly delayed in aged skin [11,12] . Both SC integrity and recovery are even more reduced in photodamaged skin compared to intrinsic aged skin [13,14] . In the present trial, EPB integrity (p = 0.007) as well as recovery (p = 0.004) significantly improved in group A after a 7-week course of treatment with pH 4.0 products.…”

Section: Discussionmentioning

confidence: 96%

“…Tape stripping studies on aged murine and human skin have revealed a reduced barrier integrity compared to young skin [11,12] . In addition, irritability by an alkaline noxe is known to be significantly higher in aged skin than in young skin, with an additional significant deficit in photoaged skin [13] . Recovery of the SC after perturbation by tape stripping or acetone is significantly delayed in human and murine aged skin compared to young skin [11,12] , with a further significant delay in photoaged skin compared to chronologically aged skin [14] .…”

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confidence: 99%

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A Long-Term Study to Evaluate Acidic Skin Care Treatment in Nursing Home Residents: Impact on Epidermal Barrier Function and Microflora in Aged Skin

Blaak¹,

Kaup²,

Hoppe³

et al. 2015

Skin Pharmacol Physiol

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Background: The pH of the stratum corneum (SC) in the elderly is elevated and linked to impaired SC function. Therefore, this paper addresses the question of whether acidic skin care generates positive clinical, biophysical, and microbiological effects in aged skin. Methods: This study was performed to assess skin care effects in nursing home residents (aged 80-97 years). Visual, biophysical, and microbiological methods were used. Subjects were randomly assigned to 1 of 2 groups and treated over 7 weeks with skin care products adjusted to a pH of 4.0 (group A) or a pH of 6.0 (group B). Results: Compared to baseline, SC integrity improved significantly in group A (p = 0.007), whereas there was no change in group B (p = 0.672). SC recovery 24 h after perturbation increased significantly in group A (p = 0.004) compared to baseline. The SC recovery in group B was not significant compared to baseline (p = 0.327). Conclusion: Long-term treatment with pH 4.0 skin care results in a significant improvement in epidermal barrier function compared to identical products with a pH of 6.0. In addition, effects on skin dryness and resident flora were demonstrated, but without significant differences, between the 2 groups. Based on these results, we recommend adjustment of skin care products for the elderly to a pH of 4.0 to maintain the health of aged skin.

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Section: Discussionmentioning

confidence: 96%

mentioning

confidence: 99%

A Long-Term Study to Evaluate Acidic Skin Care Treatment in Nursing Home Residents: Impact on Epidermal Barrier Function and Microflora in Aged Skin

Blaak¹,

Kaup²,

Hoppe³

et al. 2015

Skin Pharmacol Physiol

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show abstract

“…Different studies, using tape stripping, revealed reduced SC integrity in aged compared to young skin . Furthermore, irritability in aged skin has been shown to be significantly higher than in young skin, especially at photoaged skin sites . SC restoration after experimental damage by acetone or stripping is obviously decelerated in aged skin compared to young skin , especially at photoaged skin sites .…”

Section: Introductionmentioning

confidence: 99%

A plant oil‐containing pH 4 emulsion improves epidermal barrier structure and enhances ceramide levels in aged skin

Blaak¹,

Dähnhardt²,

Dähnhardt‐Pfeiffer³

et al. 2016

Intern J of Cosmetic Sci

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“…18 For a better understanding of photocarcinogenesis and the concept of "sun damage," intrinsic skin aging is frequently compared to photodamaged skin. 23 Sun-protected areas such as the buttock skin, 24 the upper inner arm (UIA), 25 and volar forearm (VFA) 26 served in clinical trials as a negative control to extrinsic aging. 23 Sun-protected areas such as the buttock skin, 24 the upper inner arm (UIA), 25 and volar forearm (VFA) 26 served in clinical trials as a negative control to extrinsic aging.…”

Section: Introductionmentioning

confidence: 99%

Effects of intrinsic aging and photodamage on skin dyspigmentation: an explorative study

et al. 2016

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Photoaging is associated with increasing pigmentary heterogeneity and darkening of skin color. However, little is known about age-related changes in skin pigmentation on sun-protected areas. The aim of this explorative study was to measure skin color and dyspigmentation using image processing and to evaluate the reliability of these parameters. Twenty-four volunteers of three age-groups were included in this explorative study. Measurements were conducted at sun-exposed and sun-protected areas. Overall skin-color estimates were similar among age groups. The hyper- and hypopigmentation indices differed significantly by age groups and their correlations with age ranged between 0.61 and 0.74. Dorsal forearm skin differed from the other investigational areas (p<0.001). We observed an increase in dyspigmentation at all skin areas, including sun-protected skin areas, already in young adulthood. Associations between age and dyspigmentation estimates were higher compared to color parameters. All color and dyspigmentation estimates showed high reliability. Dyspigmentation parameters seem to be better biomarkers for UV damage than the overall color measurements.

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Irritability of the skin barrier: A comparison of chronologically aged and photo-aged skin in elderly and young adults

Cited by 19 publications

References 36 publications

A Long-Term Study to Evaluate Acidic Skin Care Treatment in Nursing Home Residents: Impact on Epidermal Barrier Function and Microflora in Aged Skin

A Long-Term Study to Evaluate Acidic Skin Care Treatment in Nursing Home Residents: Impact on Epidermal Barrier Function and Microflora in Aged Skin

A plant oil‐containing pH 4 emulsion improves epidermal barrier structure and enhances ceramide levels in aged skin

Effects of intrinsic aging and photodamage on skin dyspigmentation: an explorative study

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