Effects of intrinsic aging and photodamage on skin dyspigmentation: an explorative study

Abstract

Photoaging is associated with increasing pigmentary heterogeneity and darkening of skin color. However, little is known about age-related changes in skin pigmentation on sun-protected areas. The aim of this explorative study was to measure skin color and dyspigmentation using image processing and to evaluate the reliability of these parameters. Twenty-four volunteers of three age-groups were included in this explorative study. Measurements were conducted at sun-exposed and sun-protected areas. Overall skin-color estimates were similar among age groups. The hyper- and hypopigmentation indices differed significantly by age groups and their correlations with age ranged between 0.61 and 0.74. Dorsal forearm skin differed from the other investigational areas (p<0.001). We observed an increase in dyspigmentation at all skin areas, including sun-protected skin areas, already in young adulthood. Associations between age and dyspigmentation estimates were higher compared to color parameters. All color and dyspigmentation estimates showed high reliability. Dyspigmentation parameters seem to be better biomarkers for UV damage than the overall color measurements.

Biological insights from self-perceived facial aging data of the UKBB participants

“…These results are in line with previously reported findings that pigmentation genes play crucial roles in skin aging [19]. Dyspigmentation is clinically associated with both intrinsic and extrinsic aging of skin and can be manifest as hyperpigmentation or hypopigmentation Indeed, as the number of melanocytes in our skin decreases and skin color in sun-protected areas lightens with age [23], aberrant pigmentation (hyper-and hypopigmentation; i.e., sun spots and freckles) occurs at chronically sun-exposed body parts [24] . The next highly significantly enriched categories are related to skin cancers and skin diseases, including rosacea (S2 Table).…”

Three‐dimensional multispectral facial imaging to monitor actinic damage treated with 5‐fluorouracil

“…RBX‐transformed images then underwent VAESTRO image analysis, computed with reference to a training data set consisting of cross‐polarised participant images across multiple skin types to develop a unique, comparative solution that operated independent of skin type. The RBX transformation method has been previously used across various studies to objectively quantify erythema or pigmentation 15–19 . Measurements were given as fractional areas representative of the ratio of the detected area with respect to the total area of the investigated region.…”

“…The RBX transformation method has been previously used across various studies to objectively quantify erythema or pigmentation. [15][16][17][18][19] Measurements were given as fractional areas representative of the ratio of the detected area with respect to the total area of the investigated region.…”

Tremella fuciformisInhibits Melanogenesis in B16F10 Cells and Promotes Migration of Human Fibroblasts and Keratinocytes

“…Increased inflammation in skin lesions results in increased and prolonged activation of melanogenesis, which may lead to uncontrolled melanocyte proliferation and melanoma (7,8). Furthermore, skin injury with disruption to normal melanogenesis causes dyspigmentation (9). Consequently, substantial research effort is directed toward promoting rapid wound healing and minimizing inflammation in injured skin to prevent pigmentation abnormalities of the resulting scar tissue (10,11).…”