Iodine Distribution in a Porcine Eye Model following Iontophoresis

Abstract

Iodine distribution was studied in isolated porcine eyes after iontophoresis using ¹³¹l-labelled solutions and chemical methods. After a 15-min treatment with a therapeutically used iodine brine, the iodine content in the ocular tissues showed the following rank order: cornea > retina > vitreous body > anterior chamber fluid > lens. Replacement of the brine by 0.15 MNal increased the uptake values in a different way, but the same rank order was maintained. The increase was highest in the cornea (5.6-fold) and only about 2-fold in the lens, nevertheless approaching now the level of 10^––⁴ M, a concentration which was regarded as being optimal for the antioxidant effect of I^––. Among the other eye components, the relatively high iodine enrichment of the retina was remarkable. The data are discussed with respect to a possible protective, antioxidative and OH-scavenging efficacy of I and to previous results in the literature concerning iodine uptake in ocular tissues.

Morphologic and Clinical Effects of Subretinal Injection of Indocyanine Green and Infracyanine Green in Rabbits

“…In chemistry, "iodine" is a nonmetallic halogen element appearing as a grayish-black crystalline solid, and it is applied in medicine as an antiseptic, dye, or radioactive isotope. 25 Topical ocular iodine conjugated with povidone may promote corneal toxicity, while high-dose intravitreal iodine could lead to uveal inflammation and retinal necrosis. 26 The biochemical instability of diatomic iodine, I 2 , demands binding to chemical intermediates to generate iodides (e.g., sodium iodide [NaI] or potassium iodide [KI]) or iodates (e.g., sodium iodate [NaIO 3 ] or calcium iodate [CaIO 3 ]).…”

Protection by iodide of lens from selenite-induced cataract

“…Literature data describing iodide penetration into the lens are sparse. In previous studies [13] it has been shown that after administration of balneotherapeutically relevant doses, the lens is one of the organs with very little iodine uptake. In pilot studies we have found a detectable, age-dependent radioactive iodine-125 penetration 150 effect of two preceding injections of iodide was significant (P=0.004).…”

Iodid schützt Bindehautzellen vor der Schädigung durch UV-Licht

“…Diese Therapie fuhrt zu einer Speicherung von Iodid in den Augengeweben [25] and somit zu einer Erhohung des antioxidativen Potentials [26]. Die positive Auswirkung dieser Therapieform bei der Behandlung von Erkrankungen des vorderen Augenabschnitts sowie des trockenen Auges durfte nach 217 unseren Untersuchungen auch auf eine Steigerung der Abwehrkraft von Zellen des vorderen Augenabschnitts gegenuber energiereichen Systemen zuruckzufuhren sein.…”