We detected a profound upregulation of both MMP-3 and MMP-9 and a mild induction of MMP-2 through latanoprost in the ciliary body, but not the trabecular meshwork or RPE cells. Corticosteroids, on the other hand, downregulated MMP expression in both tissues. This inhibiting effect of corticosteroids on MMP production was reversed by latanoprost.

Using a special embedding method, autopsied eyes with proliferative diabetic retinopathy were studied. In areas with no posterior vitreous detachment, small proliferations may arise multifocally and grow within the vitreous cortex. The fibrous material of the vitreous cortex is densely interconnected with and obviously incorporated into the newly formed proliferated tissue, a process which causes coarse traction lines on the vitreous cortex lamellae. The clinical consequences of these findings are discussed.

SUMMARYThe results of treating 72 severely injured eyes by primary vitrectomy combined with anterior and posterior segment reconstruction are presented. This approach aims at improving the visual prognosis by allowing fundus examination and immediate retinal surgery where indicated, and by preventing the more severe complications associated with vitreous and anterior segment disorganisation. The prospects for improved visual results and the problems encountered, particularly secondary haemorrhage, are discussed.

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A 49-year-old patient developed pupillary block glaucoma with an intraocular pressure (IOP) of 29 mm hg after implantation of a phakic intraocular lens (IOL) (NuVita, Bausch & Lomb) in the left eye. the anterior chamber deepened again, and the iop decreased to 16 mm hg after a neodymium: YAG iridotomy. Pupillary block glaucoma may occur after phakic IOL implantation without iridotomy, and we advocate that routine iridotomy be performed during phakic IOL surgeries.