Morphologic and Clinical Effects of Subretinal Injection of Indocyanine Green and Infracyanine Green in Rabbits

Penha, Fernando M.; Maia, Maurício; Farah, Michel Eid; Dib, Eduardo; Príncipe, A.H.; Devin, F.; Rodrigues, Eduardo B.; Duprat, João Paulo; Freymüller, Edna

doi:10.1089/jop.2007.0047

Cited by 29 publications

(21 citation statements)

References 40 publications

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“…One of the new tools of vitrectomy are substances capable of dyeing the structures intraocular facilitating visibility. Some dyes have been well studied as indocyanine green (ICG), trypan blue and more recently the sodium fluorescein (6)(7)(8)(9)(10) .…”

Section: Discussionmentioning

confidence: 99%

Intravenous sodium fluorescein enhances the visibility of vitreous during vitrectomy surgery for diabetic retinopathy

Siqueira¹,

Jorge

Canamary

2008

Rev. bras.oftalmol.

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Section: Discussionmentioning

confidence: 99%

Intravenous sodium fluorescein enhances the visibility of vitreous during vitrectomy surgery for diabetic retinopathy

Siqueira¹,

Jorge

Canamary

2008

Rev. bras.oftalmol.

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“…Toxicological studies have been carried out in rabbits for different purposes: to evaluate the morphological and clinical effects on the retina after subretinal injection of drugs [14,[74][75][76][77][78] , for the treatment or prevention of endophthalmitis with antibiotics [79] or antifungal agents [80,81] , and for the prevention of tractional retinal detachment in an experimental model of proliferative vitreoretinopathy treated with intravitreal implants loaded with daunomycin [79,82] or a combination of triamcinolone acetonide and 5-fluorouracil [83] .…”

Section: Rabbitsmentioning

confidence: 99%

Retinal and Ocular Toxicity in Ocular Application of Drugs and Chemicals – Part I: Animal Models and Toxicity Assays

et al. 2010

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Aims: Experimental retinal research has gained great importance due to the ophthalmic pharmacotherapy era. An increasing number of drugs are constantly released into the market for the treatment of retinal diseases. In this review, animal species, animal models and toxicity assays in retinal research are discussed. Methods: An extensive search of the literature was performed to review various aspects of the methods of investigation of drug toxicity. The different types of animal species, as well as single animal models available for the evaluation of safety and efficacy of retinal pharmacotherapy, were identified. In addition, a large variety of reported laboratory techniques were critically examined. Results: In vitro studies are the first-line experiments for the development of a new drug for retinal diseases, using retinal pigment epithelial cells and other cell lines. The next step involves in vivo animal studies where nonhuman primates are considered the gold standard. However, cost and legal issues make their use difficult. Mice and rats provide genetically controlled models for investigations. Pigs, dogs and cats represent good large-size animal models, while rabbits are one of the most used species for retinal toxicity evaluations. Various laboratory methods were identified, including light microscopy, electron microscopy, electroretinography and new emerging methods, such as optical coherence tomography and scanning laser ophthalmoscopy for experimental purposes. Conclusions: A great number of animal species and models are available that simulate retinal diseases and provide experimental data for further human use. Work with animal models should include properly designed toxicity assays to obtain reliable results for safety and efficacy.

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“…Corantes são componentes químicos que se ligam a substân-cias e alteram sua aparência, facilitando assim a diferenciação de outros tecidos e atuando como ferramentas úteis para a identificação de microestruturas durante procedimentos cirúrgicos (37)(38) . Uma técnica cirúrgica específica utilizada em cirurgias de mácula envolve a retirada da membrana limitante interna, e trabalhos apontam uma progressiva experiência cirúrgica com corantes como a indocianina verde, azul brilhante (ideais para corar a membrana limitante interna), azul de tripan e azul patente (indicado para corar a membrana epirretiniana) e acetonido de triancinolona (que se deposita sobre a hialóide posterior, facilitando assim sua identificação) (39)(40) .…”

Section: Outras Aplicações Da Farmacologia Ocularunclassified

Farmacologia ocular aplicada no tratamento de doenças do vítreo, retina e coróide

Filho¹,

Maia²,

Rodrigues³

et al. 2010

Arq. Bras. Oftalmol.

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Morphologic and Clinical Effects of Subretinal Injection of Indocyanine Green and Infracyanine Green in Rabbits

Abstract: Subretinal injection of 0.05% ICG results in more significant retinal damage than 0.5% IfCG. In this model, iodine-free IfCG demonstrates a safer profile than a tenfold lower concentration of ICG, which contains iodine in its composition.

Cited by 29 publications

References 40 publications

Intravenous sodium fluorescein enhances the visibility of vitreous during vitrectomy surgery for diabetic retinopathy

Intravenous sodium fluorescein enhances the visibility of vitreous during vitrectomy surgery for diabetic retinopathy

Retinal and Ocular Toxicity in Ocular Application of Drugs and Chemicals – Part I: Animal Models and Toxicity Assays

Farmacologia ocular aplicada no tratamento de doenças do vítreo, retina e coróide

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