Investigations of cephalosporin C production in an airlift tower loop reactor

Bayer, Thomas; Zhou, Weichang; Holzhauer, K.; Schügerl, K.

doi:10.1007/bf00255992

Cited by 40 publications

(7 citation statements)

References 8 publications

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“…Some of the results obtained in this investigation are somewhat comparable to those reported by BAYER et al [9], but their experimental strategy was different and the evaluation of the results more complex.…”

Section: Comparison Of Final Resultssupporting

confidence: 77%

“…power requirement for aeration and mixing) [ll]. The airlift bioreactor is one of the most promising devices for gas-liquid mass transfer and is being considered especially for fermentation processes, including the antibiotic biosynthesis [7, [9][10][11][12]. In contrast to the conventional stirred tank bioreactor, the airlift contactors have no moving parts and the only power requirement comes from the air compressor which delivers the air through a sparging system.…”

Section: Introductionmentioning

confidence: 99%

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Cultivation of a filamentous mould in an airlift bioreactor

Roman

1995

Acta Biotechnologica

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Cephalosporin C biosynthesis was investigated in a pilot-plant external-loop airlift bioreactor for evaluating the capacity of this bioreactor to surpass the problems which arise from the morphology of the mould and the rheology of the broth.Some of the results were compared with those obtained in a stirred tank bioreactor.The dilution and the use of static mixers was necessary to overcome the effects of the high viscosities. The oxygen transfer rate represented 84% of that in the stirred bioreactor, but the efficiency of the power utilization was higher. The specific productivity of Cephalosporin C is comparable to that obtained in the stirred tank bioreactor, but the average specitic power consumption was found to be */3 of that in the stirred vessel.

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Section: Comparison Of Final Resultssupporting

confidence: 77%

Section: Introductionmentioning

confidence: 99%

Cultivation of a filamentous mould in an airlift bioreactor

Roman

1995

Acta Biotechnologica

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“…In fermentations with free cells Bayer et al (1989) observed lower cephalosporin productivity if oxygen availability was limited. Low OTRs, since they are typical of highly viscose media, are often responsible for limited antibiotic productivity in submersed fermentations.…”

Section: Discussionmentioning

confidence: 93%

Effects of oxygen supply on the production of nikkomycin with immobilized cells of Streptomyces tendae

Trück

Chmiel

Hammes

et al. 1990

Appl Microbiol Biotechnol

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For continuous production of the antibiotic nikkomycin immobilized cells have been used in a fluidized bed bioreactor. Cells of Streptomyces tendae were immobilized on sintered glass particles. Different biomass concentrations on the particles correspond to different thicknesses of mycelial layers because growth occurs only on the outer surface of the particles. The antibiotic productivity decreased with increasing layer thickness. In fermentations with higher concentrations of both biomass on the particles and dissolved oxygen levels of about 70% the productivity was also limited because of limited oxygen diffusion in the layers.

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“…Although bubble columns and airlift reactors have been used in many fermentation processes [6][7][8][9][10], they are seldom used in amino acid fermentation. In the previous study, an airlift reactor with net draft tube has been developed [11] where a solid draft tube in the airlift reactor is replaced by a net one.…”

Section: Introductionmentioning

confidence: 99%

Glutamic acid production in an airlift reactor with net draft tube

1992

Bioprocess Engineering

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Abstract. Cultivation of Brevibacterium divaricatum for glutamic acid production in an airlift reactor with net draft tube was developed. Cell concentration gave an index for adding penicillin G. On-line estimation of total sugar concentration yielded an identified model which was used for determination of the substrate addition. Fermentation for glutamic acid production requires high oxygen concentration in the broth. The proposed reactor has the capability to provide sufficient oxygen for the fermentation. Since the reactor is suitable for fed-batch culture, the cultivation of B. divaricatum for glutamic acid production in the proposed reactor is successfully carried out.

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Investigations of cephalosporin C production in an airlift tower loop reactor

Cited by 40 publications

References 8 publications

Cultivation of a filamentous mould in an airlift bioreactor

Cultivation of a filamentous mould in an airlift bioreactor

Effects of oxygen supply on the production of nikkomycin with immobilized cells of Streptomyces tendae

Glutamic acid production in an airlift reactor with net draft tube

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