Effects of oxygen supply on the production of nikkomycin with immobilized cells of Streptomyces tendae

Trück, H. Uwe; Chmiel, H.; Hammes, Walter P.; Trösch, Walter

doi:10.1007/bf00170913

Cited by 3 publications

References 13 publications

(11 reference statements)

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Bioprocess Intensification for Production of Novel Marine Bacterial Antibiotics Through Bioreactor Operation and Design

1999

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: There is a lack of research into bioreactor engineering and fermentation protocol design in the field of marine bacterial antibiotic production. Most production strategies are carried out at the shake-flask level and lack a mechanistic understanding of the antibiotic production process, offering poor prospects for successful scale-up. This review shows that data need to be collated on media and physical optima differences between the trophophase and idiophase, along with investigations into the control mechanisms for biosynthesis, to allow implementation of novel fermentation protocols. Immobilization may play a part in bioprocess intensification of marine bacterial antibiotic production, through again this area is understudied. Similarly, mass transfer and shear stress data of fermentations are needed to provide the bioreactor design requirements to intensify antibiotic biosynthesis, with process scale-up in mind. The application of bioprocess intensification methods to the production of antibiotics (and other metabolites) from marine microbes will become an important strategy for improving supply of natural products, in order to assess their suitability as chemotherapeutic drugs.

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Bioprocess Intensification for Production of Novel Marine Bacterial Antibiotics Through Bioreactor Operation and Design

1999

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Oxytetracycline production by free and immobilized cells of Streptomyces rimosus in batch and repeated batch cultures

El‐Enshasy

Farid

El‐Diwany

1996

Immobilized Cells - Basics and Applications, Proceedings of an International Symposium Organized Under Auspices of the Working

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Reactive Oxygen Species, Cell Growth, and Taxol Production of <I>Taxus cuspidata</I> Cells Immobilized on Polyurethane Foam

De-ming

Yang

2005

ABAB

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Dynamic changes in reactive oxygen species (ROS) of Taxus cuspidata cells immobilized on polyurethane foam were investigated and the relation between ROS content and taxol production was discussed. Immobilization shortened the lag period of cell growth and moderately increased H2O2 and O2-* contents inside the microenvironment within the first 15 d. After 20 d, excessive production of H2O2 and O2-* was observed accompanied by marked increases in membrane lipid peroxidation and cell membrane permeability. The taxol content of immobilized cells was fourfold that of suspended cells at d 35. The addition of exogenous H2O2 barely affected malondialdehyde content and cell membrane permeability but led to an obvious accumulation of taxol. It is inferred that the intracellular and extracellular H2O2 inside the microenvironment might be one factor promoting taxol biosynthesis under the immobilization stress.

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Effects of oxygen supply on the production of nikkomycin with immobilized cells of Streptomyces tendae

Cited by 3 publications

References 13 publications

Bioprocess Intensification for Production of Novel Marine Bacterial Antibiotics Through Bioreactor Operation and Design

Bioprocess Intensification for Production of Novel Marine Bacterial Antibiotics Through Bioreactor Operation and Design

Oxytetracycline production by free and immobilized cells of Streptomyces rimosus in batch and repeated batch cultures

Reactive Oxygen Species, Cell Growth, and Taxol Production of <I>Taxus cuspidata</I> Cells Immobilized on Polyurethane Foam

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