Investigation of the protective effects of horse mushroom (Agaricus arvensis Schaeff.) against carbon tetrachloride-induced oxidative stress in rats

Abstract

Wild and cultured mushrooms have been extensively used for food and medicinal purposes all around the world. However, there is limited information on chemical composition, health enhancing effects and contributions on diet of some mushrooms (e.g., Agaricus arvensis) widely distributed in many countries including United Kingdom, Australia, Turkey etc. Therefore, the present study was aimed to analyse the bioactive composition and ameliorative effects of A. arvensis via evaluating in vitro and in vivo antioxidant properties in CCl induced rat model. The extract exhibited higher antioxidant capacities in vitro than that of the positive control (Reishi-Shiitake-Maitake standardized extract). Administration of the extract had significant regulative effects in the levels of AST, ALT, LDH, Urea and TRIG levels according to CCl group. Additionally, lipid peroxidation and GSH in the brain, kidney and liver tissues was regulated by extract treated groups compared to the CCI group. The supplementation of the extract at the dose of 100 mg/kg regulated the levels of GST, GR, CAT and GPx enzyme activities in brain and liver, but not in kidney tissue. There was approximately three fold increase in CAT enzyme activity in kidney tissue of extract treated groups compared to Control and CCl groups. The extract contained a rich composition of bioactive compounds including phenolics (protocatechuic acid and p-hydroxybenzoic acid), volatile compounds (benzaldehyde, palmitic acid and linoleic acid) and mineral compounds (K, Si, Mg and Na). Data obtained within this study suggests that A. arvensis might be used for food industries in order to obtain nutritional products.

Ameliorative role ofCyanus depressus(M.Bieb.) Soják plant extract against diabetes‐associated oxidative‐stress‐induced liver, kidney, and pancreas damage in rats

“…The lyophilized extract was prepared according to Dogan et al (2018). In summary, the plant samples, which were cleaned of soil, dust, and insects, were allowed to dry thoroughly in a shaded laboratory environment.…”

“…They were allowed to thaw on ice. Buffer containing 50 mM of KH 2 PO 4 and 1 mmol/L of EDTA (pH: 7.4) was used for extraction (Dogan et al, 2018). Next, 500 mg of tissue was weighed and 5 ml of cold buffer was added.…”

Exploring phytochemical constituents ofAchillea arabicaKotschy. ethanolic flower extract by LC-MS/MS and its possible antioxidant and antidiabetic effects in diabetic rats

“…The plant ethanolic lyophilized extract was prepared according to the method of Dogan et al (2018), with some modifications. The flower samples were dried in the shade and crushed into a fine powder.…”

Achillea arabica Kotschy. Liyolifilize Etanolik Ekstresinin Streptozotosin ile Diyabet Oluşturulan Ratların Adacık  Hücreleri Üzerindeki Koruyucu Etkileri

“…Extraction of the lyophilized ethanolic was performed according to the methods of Dogan et al, (2018), with some modifications. In brief, 50 g of the ground and powdered dry material from the inflorescence was mixed with an ethanol:water (80:20) solvent (1 L), for 2 h at room temperature, by continuous shaking, and then filtered.…”