Achillea arabica Kotschy. Liyolifilize Etanolik Ekstresinin Streptozotosin ile Diyabet Oluşturulan Ratların Adacık  Hücreleri Üzerindeki Koruyucu Etkileri

In this original article, we aimed to assess the ameliorative role of Cyanus depressus (CD) plant ethanolic extract treatment of streptozotocin (STZ)-induced liver, kidney, and pancreas damage in rats. The rats were divided into five groups (n = 7): control, CD, Diabetes mellitus (DM), DM + CD, and DM + glibenclamide (Gly). The DM groups were injected with a single dose of 50 mg/kg STZ intraperitoneally (i.p.). While the CD and DM + CD groups received 400 mg/kg/day intragastrically for 21 days, the DM + Gly group received 3 mg/kg/day of Gly intragastrically throughout the experiment. Statistically significance was accepted as p < .05. According to our liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) data, quinic acid, cosmosiin, nicotiflorin, apigenin, and protocatechuic acid were the major compounds, in descending order. Weekly blood glucose, serum glucose, aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH) and urea, malondialdehyde (MDA) (liver and pancreas), and blood glycosylated hemoglobin % (HbA1c %) were significantly decreased, whereas finally live body weights (LBWs), reduced glutathione (GSH), glutathione S-transferase (GST) and catalase (CAT) (pancreas), and pancreatic islet diameter and area were increased significantly in the CD-treated diabetic group. Moreover, CD administration was found to be effective in the protection of the histology of the liver, kidneys, and pancreatic islets in the STZ-induced rats. Consequently, we concluded that CD administration reduces hyperglycemia, oxidative stress, and histopathology in STZinduced experimental rats by improving antioxidant defenses. Practical applicationsToday, the prevalence of diabetes is increasing rapidly throughout the world and it causes complications such as kidney damage, blindness, amputations, and cardiovascular diseases. Despite medical technological advances, people's interest in medicinal herbal products is gradually increasing. Biochemical and histopathological findings showed that the use of the plant CD at the determined dose (400 mg/kg/day) in rats with DM by STZ had strong antioxidant and antidiabetic effects. CD may have a drug How to cite this article: Duman, K. E., Dogan, A., & Kaptaner, B. (2022). Ameliorative role of Cyanus depressus (M.Bieb.) Soják plant extract against diabetes-associated oxidative-stressinduced liver, kidney, and pancreas damage in rats.

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Ameliorative role ofCyanus depressus(M.Bieb.) Soják plant extract against diabetes‐associated oxidative‐stress‐induced liver, kidney, and pancreas damage in rats

Duman

Doğan

Kaptaner

2022

Journal of Food Biochemistry

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Exploring phytochemical constituents ofAchillea arabicaKotschy. ethanolic flower extract by LC-MS/MS and its possible antioxidant and antidiabetic effects in diabetic rats

Hanalp

Doğan

Saygi³

et al. 2022

Zeitschrift Für Naturforschung C

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The aim of this study was to reveal the antidiabetic and antioxidant effects of ethanolic lyophilized extract of Achillea arabica flower extract against streptozotosine (STZ)-induced in diabetic rats and to determine its phytochemical content by liquid chromatography with tandem mass spectrometry (LC-MS/MS). After toxicity test, 35 female rats were divided into five groups. Control, diabetes mellitus (DM), A.arabica (400 mg/kg) extract, DM + A. arabica (400 mg/kg) extract and DM + Glibenclamide (2 mg/kg). It was determined that while diabetic rats treated A.arabica plant extract significantly decreased blood glucose level, serum glucose, HbA1c, liver and kidney damage biomarker levels, and malondialdehyde (MDA) content compared to the DM group, it caused fluctuations in antioxidant enzyme levels. According to LC-MS/MS results of A. arabica flower extract, quinic acid (2439.9 μg/g), cyranoside (858.4 μg/g), chlorogenic acid (698.7 μg/g), and cosmosiin (347.8 μg/g) were determined as major compounds, respectively. In addition, two new compounds were determined in this extract according to nuclear magnetic resonance (NMR) and Mass analyses and these compounds were named edremitine and achillosine, respectively. Thus, A.arabica flower extract has possible therapeutic effects to prevent high blood glucose level and oxidative stress caused by DM in liver and kidney via its high phenolic content.

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Bisfenol F’nin Sıçan Pankreası Üzerindeki Toksik Etkileri

Doğan

Kaptaner

Doğan

2022

Yüzüncü Yıl Üniversitesi Fen Bilimleri Enstitüsü Dergisi

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In this study, it was aimed to investigate the toxic effects of BPF on rat pancreas. Toward this aim, male Wistar albino rats were exposed to BPF at concentrations of 0, 20, 100, and 500 mg/kg of body weight (b.w.) via oral gavage for 28 days. According to the histological examinations, the presence of cells displaying vacuolar degeneration in the pancreatic Langerhans islets was determined after BPF exposure. Histomorphometric measurements demonstrated that averages of the islet diameter and area decreased in the groups exposed to BPF concentrations of 100 and 500 mg/kg of b.w. In addition, the percentage of immunohistochemically-stained insulin-positive B cells in the islets was determined to have diminished significantly at all of the groups exposed to BPF. The levels of serum fasting glucose, total blood HbA1c, serum C-peptide or insulin did not display significant changes after BPF exposure. BPF was determined to lead significant changes in the antioxidant defense system indicators of the pancreas, except for the malondialdehyde level. The results obtained herein showed that more attention should be given regarding the usage of BPF instead of BPA as a safe alternative in industrial areas.

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Achillea arabica Kotschy. Liyolifilize Etanolik Ekstresinin Streptozotosin ile Diyabet Oluşturulan Ratların Adacık  Hücreleri Üzerindeki Koruyucu Etkileri

Cited by 3 publications

References 40 publications

Ameliorative role ofCyanus depressus(M.Bieb.) Soják plant extract against diabetes‐associated oxidative‐stress‐induced liver, kidney, and pancreas damage in rats

Ameliorative role ofCyanus depressus(M.Bieb.) Soják plant extract against diabetes‐associated oxidative‐stress‐induced liver, kidney, and pancreas damage in rats

Exploring phytochemical constituents ofAchillea arabicaKotschy. ethanolic flower extract by LC-MS/MS and its possible antioxidant and antidiabetic effects in diabetic rats

Bisfenol F’nin Sıçan Pankreası Üzerindeki Toksik Etkileri

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