Exploring phytochemical constituents of<i>Achillea arabica</i>Kotschy. ethanolic flower extract by LC-MS/MS and its possible antioxidant and antidiabetic effects in diabetic rats

Hanalp, Hanife Ceren; Doğan, Abdulahad; Saygi, Tuba Kusman; Dönmez, Fatih; Battal, Abdulhamit

doi:10.1515/znc-2022-0082

Cited by 5 publications

(2 citation statements)

References 42 publications

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“…Many studies have reported that phytochemicals can ameliorate obesity-induced diabetes mellitus in vivo and in vitro [ 28 , 29 ]. In this study, we have demonstrated that phycocyanin can protect against high glucose high fat diet induced diabetes mellitus in mice and can also ameliorate the insulin-resistant effect of SMMC-7721 cells.…”

Section: Discussionmentioning

confidence: 99%

Phycocyanin Protects against High Glucose High Fat Diet Induced Diabetes in Mice and Participates in AKT and AMPK Signaling

Hao

et al. 2022

Foods

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Phycocyanin is a type of marine natural product and functional food additive. Studies have demonstrated that phycocyanin has potential regulatory effects on glycometabolism, while its function and mechanism, especially in type 2 diabetes mellitus (T2DM), is still unclear. The aim of this study was to investigate the antidiabetic roles and underlying mechanism of phycocyanin in a high glucose high fat diet induced model of T2MD in C57BL/6N mice and a high-insulin-induced insulin-resistant model of SMMC-7721 cells. The results indicated that phycocyanin reduced high glucose high fat diet induced hyperglycemia as well as ameliorated glucose tolerance and histological changes in the liver and pancreas. Meanwhile, phycocyanin also significantly decreased the diabetes-induced abnormal serum biomarker variations, including triglyceride (TG), total cholesterol (TC), aspartate transaminase (AST), and glutamic-pyruvic transaminase (ALT), and increased the superoxide dismutase (SOD) content. Furthermore, the antidiabetic function of phycocyanin was exerted through activating the AKT and AMPK signaling pathway in the mouse liver, which was also verified in the insulin-resistant SMMC-7721 cells due to increased glucose uptake and activated AKT and AMPKα expression. Thus, the present study is the first to indicate that phycocyanin mediates antidiabetic function via activating the AKT and AMPK pathway in high glucose high fat diet induced T2DM mice and insulin-resistant SMMC-7721 cells, which lays a scientific theoretical basis for the potential treatment of diabetes and the utilization of marine natural products.

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Section: Discussionmentioning

confidence: 99%

Phycocyanin Protects against High Glucose High Fat Diet Induced Diabetes in Mice and Participates in AKT and AMPK Signaling

Hao

et al. 2022

Foods

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“…CGA lowers the absorption of glucose in the stomach by inhibiting G‐6‐phosphate translocase and sodium‐glucose cotransporter (Meng et al., 2013 ). The presence of major compounds, such as quinic acid, cyranoside, CGA, and cosmosiin in the Achillea arabica flower extract, lyophilized in ethanol showed significant antioxidant effects in streptozotocin‐induced diabetic rats, reducing blood glucose, serum glucose, HbA1c, liver, and kidney damage biomarkers (Hanalp et al., 2023 ). A research article by Kato et al.…”

Section: Promising Dietary Phenolic Compoundsmentioning

confidence: 99%

Dietary phenolic compounds as promising therapeutic agents for diabetes and its complications: A comprehensive review

Aryal,

Joshi,

Thapa

et al. 2024

Food Science & Nutrition

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In the middle of an ever‐changing landscape of diabetes care, precision medicine, and lifestyle therapies are becoming increasingly important. Dietary polyphenols are like hidden allies found in our everyday meals. These biomolecules, found commonly in fruits, vegetables, and various plant‐based sources, hold revolutionary potential within their molecular structure in the way we approach diabetes and its intimidating consequences. There are currently numerous types of diabetes medications, but they are not appropriate for all patients due to limitations in dosages, side effects, drug resistance, a lack of efficacy, and ethnicity. Currently, there has been increased interest in practicing herbal remedies to manage diabetes and its related complications. This article aims to summarize the potential of dietary polyphenols as a foundation in the treatment of diabetes and its associated consequences. We found that most polyphenols inhibit enzymes linked to diabetes. This review outlines the potential benefits of selected molecules, including kaempferol, catechins, rosmarinic acid, apigenin, chlorogenic acid, and caffeic acid, in managing diabetes mellitus as these compounds have exhibited promising results in in vitro, in vivo, in silico, and some preclinical trials study. This encompassing exploration reveals the multifaceted impact of polyphenols not only in mitigating diabetes but also in addressing associated conditions like inflammation, obesity, and even cancer. Their mechanisms involve antioxidant functions, immune modulation, and proinflammatory enzyme regulation. Furthermore, these molecules exhibit anti‐tumor activities, influence cellular pathways, and activate AMPK pathways, offering a less toxic, cost‐effective, and sustainable approach to addressing diabetes and its complications.

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miR-338-3p and miR-34a-5p act as antagonists in phycocyanin-mediated process of ameliorating glycometabolism in T2DM HepG2 cells

Zhang,

Wu,

Cheng

et al. 2024

Journal of Functional Foods

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Exploring phytochemical constituents ofAchillea arabicaKotschy. ethanolic flower extract by LC-MS/MS and its possible antioxidant and antidiabetic effects in diabetic rats

Cited by 5 publications

References 42 publications

Phycocyanin Protects against High Glucose High Fat Diet Induced Diabetes in Mice and Participates in AKT and AMPK Signaling

Phycocyanin Protects against High Glucose High Fat Diet Induced Diabetes in Mice and Participates in AKT and AMPK Signaling

Dietary phenolic compounds as promising therapeutic agents for diabetes and its complications: A comprehensive review

miR-338-3p and miR-34a-5p act as antagonists in phycocyanin-mediated process of ameliorating glycometabolism in T2DM HepG2 cells

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