Investigation of the Interactions in Complexes of Low Molecular Weight Chitosan with Ibuprofen

Qandil, Amjad M.; Obaidat, Aiman A.; Ali, Muaadh A. Mohammed; Al-Taani, Bashar; Tashtoush, Bassam M.; Al-Jbour, Nawzat; Remawi, Mayyas M. Al; Al-Sou’od, Khaldoun A.; Badwan, Adnan A.

doi:10.1007/s10953-009-9405-4

Cited by 38 publications

(29 citation statements)

References 22 publications

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“…Herein the spectrum shows to LMWC only as the formed diclofenac acid is water insoluble and hence it will precipitate. Also, the dissociation of the complexes by a base or an acid indicates that these complexes are ionic in nature as reported previously with ibuprofen 13 .…”

Section: Nuclear Magnetic Resonancesupporting

confidence: 75%

“…Under the conditions used here, average molecular weights of the prepared LMWC polymer were 6, 13 and 30 kDa depending on time of acid hydrolysis [13][14][15] .…”

Section: Characterization Of the Prepared Lmwc Polymer In Terms Of Momentioning

confidence: 96%

“…For example, LMWC was complexed with the acidic drug ibuprofen. These complexes hindered the release of the complexed ibuprofen, and its behavior in solution dependent on the number of NH 2 groups available for the reaction with the acidic moieties 13 .…”

Section: Research Articlementioning

confidence: 99%

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A new controlled-release liquid delivery system based on diclofenac potassium and low molecular weight chitosan complex solubilized in polysorbates

Athamneh

Tashtoush

Qandil

et al. 2012

Drug Development and Industrial Pharmacy

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A complex of low molecular weight chitosan (LMWC) with oleic acid and diclofenac potassium (DP) was prepared and dispersed in high concentrations of polysorbate 20, 60 and 80 in water to form a solution which releases its components slowly. The formed complex was characterized using different analytical methods. The size of the resulted nanoparticles and the effect of tweens on size were followed using dynamic light scattering (DLS). The release of DP from this delivery system was monitored by altering the molecular weight of chitosan and the type and concentration of the polysorbates used. The most suitable preparation consisted of DP, LMWC 13 kDa, and oleic acid. This was dispersed in 5% Tween 80 and the release was followed by the adaptation of USP II apparatus using a cellophane bag. This preparation offers a release of up to 24 h.

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Section: Nuclear Magnetic Resonancesupporting

confidence: 75%

“…Under the conditions used here, average molecular weights of the prepared LMWC polymer were 6, 13 and 30 kDa depending on time of acid hydrolysis [13][14][15] .…”

Section: Characterization Of the Prepared Lmwc Polymer In Terms Of Momentioning

confidence: 96%

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A new controlled-release liquid delivery system based on diclofenac potassium and low molecular weight chitosan complex solubilized in polysorbates

Athamneh

Tashtoush

Qandil

et al. 2012

Drug Development and Industrial Pharmacy

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“…Chitosan is mainly identified and characterized by three parameters: molecular weight, degree of deacetylation, and polydispersity [2]. Nowadays a lot of research is concentrated on the conversion of chitosan to oligosaccharides [2,[4][5][6]. In order to improve the solubility of chitosan and thus to increase its range of applications various chemical modifications have been investigated [3].…”

Section: Introductionmentioning

confidence: 99%

Acid Hydrolysis of Chitosan to Oligomers Using Hydrochloric Acid

2019

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The natural polymer chitosan is widely used for medical and drug delivery applications. Low molecular weight chitosan (LMWC) has superior properties compared to high molecular weight chitosan (HMWC), which open new applications of LMWC, especially in the cosmetics, food, and pharmaceutical industries. LMWC is often produced from HMWC by acid, enzymatic, or oxidative hydrolysis. Industrially, hydrolysis with dilute HCl is preferred, since it is simple, practical, and gives a high yield. In this study 2M HCl was used to prepare LMWC. A high average depolymerization yield of 87% was obtained. The LMWCs were characterized by FTIR spectroscopy, and the molecular weight and degree of deacetylation were determined. The prepared LMWCs are fully deacetylated, and their production by this method is reproducible.

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“…Further, LMCH is also reported to form a polyelectrolyte complex (PEC) with anionic compounds (11). Although the data from solid state interaction studies did not reveal interaction between LMCH and XG, there is a strong possibility that such interaction might occur when the formulation is exposed to 0.1 mol L -1 HCl during dissolution studies.…”

Section: Liquid State Interaction Studiesmentioning

confidence: 99%

Low molecular mass chitosan as carrier for a hydrodynamically balanced system for sustained delivery of ciprofloxacin hydrochloride

Verma¹,

Bansal²,

Ghosh³

et al. 2012

Acta Pharmaceutica

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An important criterion in the selection of polymers as carriers for drug delivery is their metabolic fate in the body or biodegradation. Researchers have strived to engineer or discover polymeric materials. Practically limitless are combinations of these materials to regulate the physical and chemical properties of drug delivery systems, such as their permeability, environmental response, surface functionality, biodegradability, and biorecognition sites to produce »intelligent» drug delivery systems. Of these, chitosan has re- Chitosan has become a focus of major interest in recent years due to its excellent biocompatibility, biodegradability and non-toxicity. Although this material has already been extensively investigated in the design of different types of drug delivery systems, it is still little explored for stomach specific drug delivery systems. The objective of the present investigation was to explore the potential of low molecular mass chitosan (LMCH) as carrier for a hydrodynamically balanced system (HBS) for sustained delivery of water soluble drug ciprofloxacin hydrochloride (CP). Various formulations were prepared by physical blending of drug and polymer(s) in varying ratios followed by encapsulation into hard gelatin capsules. All the formulations remained buoyant in 0.1 mol L -1 HCl (pH 1.2) throughout the experiment. Effect of addition of xanthan gum (XG) or ethyl cellulose (EC) on drug release was also investigated. Zero order drug release was obtained from the formulations containing LMCH alone or in combination with XG, and in one instance also with EC. Our results suggest that LMCH alone or in combination with XG is an excellent material for stomach specific sustained delivery of CP from hydrodynamically balanced single unit capsules.

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Investigation of the Interactions in Complexes of Low Molecular Weight Chitosan with Ibuprofen

Cited by 38 publications

References 22 publications

A new controlled-release liquid delivery system based on diclofenac potassium and low molecular weight chitosan complex solubilized in polysorbates

A new controlled-release liquid delivery system based on diclofenac potassium and low molecular weight chitosan complex solubilized in polysorbates

Acid Hydrolysis of Chitosan to Oligomers Using Hydrochloric Acid

Low molecular mass chitosan as carrier for a hydrodynamically balanced system for sustained delivery of ciprofloxacin hydrochloride

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