A new controlled-release liquid delivery system based on diclofenac potassium and low molecular weight chitosan complex solubilized in polysorbates

Abstract

A complex of low molecular weight chitosan (LMWC) with oleic acid and diclofenac potassium (DP) was prepared and dispersed in high concentrations of polysorbate 20, 60 and 80 in water to form a solution which releases its components slowly. The formed complex was characterized using different analytical methods. The size of the resulted nanoparticles and the effect of tweens on size were followed using dynamic light scattering (DLS). The release of DP from this delivery system was monitored by altering the molecular weight of chitosan and the type and concentration of the polysorbates used. The most suitable preparation consisted of DP, LMWC 13 kDa, and oleic acid. This was dispersed in 5% Tween 80 and the release was followed by the adaptation of USP II apparatus using a cellophane bag. This preparation offers a release of up to 24 h.

Acid Hydrolysis of Chitosan to Oligomers Using Hydrochloric Acid

“…Chitosan is mainly identified and characterized by three parameters: molecular weight, degree of deacetylation, and polydispersity [2]. Nowadays a lot of research is concentrated on the conversion of chitosan to oligosaccharides [2,[4][5][6]. In order to improve the solubility of chitosan and thus to increase its range of applications various chemical modifications have been investigated [3].…”

Chitin and Chitosan as Direct Compression Excipients in Pharmaceutical Applications

“…Chitosan has shown promise for use in different biomedical applications because of its high specific surface area and high porosity. For example, chitosan has been used in surgical sutures, dental implants, renewable artificial skin, bone rebuilding, contact lenses, controlled release of drugs for animals and humans, and as encapsulating material [ 15 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 ]. In addition, it has applications in agriculture, water and waste treatment, food and beverages, cosmetics and toiletries, and biopharmaceutical products [ 15 , 39 ].…”

Preparation and Characterization of Low Molecular Weight Chitosan With Different Degrees of Deacetylation by the Acid Hydrolysis Method

“…Also all peaks assigned to the saccharide structures are available in all grades, where the peak around 2890 cm -1 represents the C-H stretch, and 1150 cm -1 represents the C-N stretch. On the other hand, the peak at 1320 cm -1 is attributed to the stretching of the C-O group [52].…”