Investigation of the antimicrobial activities of various antimicrobial agents on Streptococcus Mutans Sortase A through computer-aided drug design (CADD) approaches

Salmanli, Merve; Yılmaz, Gizem Tatar; Tüzüner, Tamer

doi:10.1016/j.cmpb.2021.106454

Cited by 12 publications

(16 citation statements)

References 36 publications

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“…Subsequently, the antibacterial properties of the DNA–HAP dental inlay were evaluated. First, Streptococcus mutans ( S. mutans ), the main pathogen responsible for causing caries, [ 46 ] was selected to study the bacterial adhesion on the inlay surface. To compare the antibacterial property of DNA–HAP films with typical natural and synthetic materials, native enamel and ZrO 2 ceramic were selected as control groups.…”

Section: Resultsmentioning

confidence: 99%

Engineering DNA‐Guided Hydroxyapatite Bulk Materials with High Stiffness and Outstanding Antimicrobial Ability for Dental Inlay Applications

et al. 2022

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However, due to the absence of long-range ordered structures in biological templates, the mechanical performance of synthetic HAP is markedly lower than that of natural bone or dentin. For example, the Young's modulus of HAP mineralized using bacterial cellulose is ≈10.9 GPa, which is significantly lower than that of human dentin (≈22.5 GPa). [11] The low mechanical stiffness and toughness of artificial HAP biomaterials limit their biomedical applications. Hence, it is important to develop novel biological templates with long-range ordering to induce high-density stacking of HAP minerals at the macroscale.DNA is an attractive template for bottom-up nanofabrication because it can be artificially synthesized and its base pair sequence can be programmed. [15][16][17][18] The multiple supramolecular interactions and molecular recognition of DNA further broaden its biomedical applications. [19][20][21][22][23][24] In particular, DNA nanotechnology is increasingly being utilized for the mineralization of inorganic materials at the nanoscale. [15,[25][26][27] Recently, Liu et al. achieved the mineralization of mechanically strong calcium phosphate (CaP) nanoparticles ranging from 10 to 100 nm using self-assembled DNA frameworks. [28] However, Programmable base pair interactions at the nanoscale make DNA an attractive scaffold for forming hydroxyapatite (HAP) nanostructures. However, engineering macroscale HAP mineralization guided by DNA molecules remains challenging. To overcome this issue, a facile strategy is developed for the fabrication of ultrastiff DNA-HAP bulk composites. The electrostatic complexation of DNA and a surfactant with a quaternary ammonium salt group enables the formation of long-range ordered scaffolds using electrospinning. The growth of 1D and 2D HAP minerals is thus realized by this DNA template at a macroscale. Remarkably, the as-prepared DNA-HAP composites exhibit an ultrahigh Young's modulus of ≈25 GPa, which is comparable to natural HAP and superior to most artificial mineralized composites. Furthermore, a new type of dental inlay with outstanding antibacterial properties is developed using the stiff DNA-HAP. The encapsulated quaternary ammonium group within the dense HAP endows the composite with long-lasting and local antibacterial activity. Therefore, this new type of super-stiff biomaterial holds great potential for oral prosthetic applications.The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/adma.202202180.

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Section: Resultsmentioning

confidence: 99%

Engineering DNA‐Guided Hydroxyapatite Bulk Materials with High Stiffness and Outstanding Antimicrobial Ability for Dental Inlay Applications

et al. 2022

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“…Flavonoids could also inhibit the bacterial respiratory electron transport chain, causing bacteria to lack energy in producing macromolecules (Kumar and Pandey 2013). In the previous research, flavonoids showed highly inhibitory activity toward S. mutans in prevent oral biofilm formation (Salmanli 2021). Plaque formation by sucrose-dependent mechanism was based on Glucosyltransferase (GTF), produced by combination of S. mutans and glucan-binding proteins (GBP).…”

Section: Discussionmentioning

confidence: 99%

Antibacterial activity of Medan Butterfly pea (Clitoria ternatea L.) corolla extract against Streptococcus mutans ATCC®25175™ and Staphylococcus aureus ATCC®6538™

Satria¹,

Sofyanti²,

Wulandari³

et al. 2022

PHAR

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Streptococcus mutans (S. mutans) and Staphylococcus aureus (S. aureus) pathogenicity that alter biofim, has become one of risk factor in orthodontic treatment. The medicinal plant’s Butterfly pea efficacy as an antibacterial agent should be confirmed in dentistry. The purpose of this study is to investigate the antibacterial activity of Medan butterfly pea corolla extract (BPCE) against S. mutans ATCC®25175™ and S. aureus ATCC®6538™. This is a laboratory experiment with Post Test Only Group Design. The minimum inhibitory concentration of BPCE is 6.25 mg/mL. The best concentration of butterfly pea extract to inhibit biofilm formation (antibiofilm) is 100 mg/mL. There was a significant difference (p < 0.05) for antibiofilm activity assays and determination of intramembrane cellular leakage. Although Medan BPCE was inadequate enough in forming antibiofilm and caused intramembrane leakage of S. mutans and S. aureus, further studies in exploring the potential morphological traits of these herbs related to orthodontic products are quite promising.

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“…In addition, IBC has certain antitrichomonas activity (Omisore et al, 2005). When used alone, it is ineffective against trypanosoma cruzi and shows trypanoidal activity when combined with 4-hydroxyl conecine rutin (Sandjo et al, 2016).…”

Section: Antibacterial and Antifungal Activitymentioning

confidence: 99%

“…When the efflux pump components (AcrAB, TolC) were absent or in the presence of efflux pump inhibitors, the antibacterial activity of IBC was significantly increased (Kuete et al, 2010). IBC can bind well to the surface protein SrtA of S. mutans, thus showing an inhibitory effect on S. mutans (Salmanli, Tatar Yilmaz, & Tuzuner, 2021; Son, Kim, Oh, & Bae, 2020). IBC also has certain antibacterial activity against Mycobacterium tuberculosis (Chiang et al, 2010; Pollo et al, 2020).…”

Section: Pharmacological Effects Of Ibcmentioning

confidence: 99%

Isobavachalcone: A comprehensive review of its plant sources, pharmacokinetics, toxicity, pharmacological activities and related molecular mechanisms

Xing

Meng

Wang

2022

Phytotherapy Research

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Isobavachalcone (IBC), also known as isobapsoralcone, is a natural flavonoid widely derived from many medicinal plants, including Fabaceae, Moraceae, and so forth. IBC has been paid more and more attention by researchers in recent years due to its pharmacological activity in many diseases. This review aims to describe in detail the plant sources, pharmacokinetics, toxicity, pharmacological activities, and molecular mechanisms of IBC on various diseases. We found that IBC can be obtained not only by extraction but also by chemical synthesis. Pharmacokinetic studies have shown that IBC has low bioavailability, but can penetrate the blood–brain barrier and is widely distributed in the brain. Its pharmacological activities mainly include anticancer, antibacterial, anti‐inflammatory, antiviral, neuroprotective, bone protection, and other activities. In particular, IBC shows strong anti‐tumor and anti‐inflammatory therapeutic potential due to its anti‐cancer and anti‐inflammatory activities. However, due to its hepatotoxicity, there may be more drug interactions. Therefore, more and more in‐depth studies are needed for its clinical application. Mechanically, IBC can induce the production of reactive oxygen species (ROS), inhibit AKT, ERK, and Wnt pathways, and promote apoptosis of cancer cells through mitochondrial or endoplasmic reticulum pathways. IBC can inhibit the NF‐κB pathway and the production of multiple inflammatory mediators by activating NRF2/HO‐1 pathway, thus producing anti‐inflammatory effects. Moreover, we discussed the limitations of current research on IBC and put forward some new perspectives and challenges, which provide a strong basis for clinical application and new drug development of IBC in the future.

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Investigation of the antimicrobial activities of various antimicrobial agents on Streptococcus Mutans Sortase A through computer-aided drug design (CADD) approaches

Cited by 12 publications

References 36 publications

Engineering DNA‐Guided Hydroxyapatite Bulk Materials with High Stiffness and Outstanding Antimicrobial Ability for Dental Inlay Applications

Engineering DNA‐Guided Hydroxyapatite Bulk Materials with High Stiffness and Outstanding Antimicrobial Ability for Dental Inlay Applications

Antibacterial activity of Medan Butterfly pea (Clitoria ternatea L.) corolla extract against Streptococcus mutans ATCC®25175™ and Staphylococcus aureus ATCC®6538™

Isobavachalcone: A comprehensive review of its plant sources, pharmacokinetics, toxicity, pharmacological activities and related molecular mechanisms

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Investigation of the antimicrobial activities of various antimicrobial agents on Streptococcus Mutans Sortase A through computer-aided drug design (CADD) approaches

Cited by 12 publications

References 36 publications

Engineering DNA‐Guided Hydroxyapatite Bulk Materials with High Stiffness and Outstanding Antimicrobial Ability for Dental Inlay Applications

Engineering DNA‐Guided Hydroxyapatite Bulk Materials with High Stiffness and Outstanding Antimicrobial Ability for Dental Inlay Applications

﻿Antibacterial activity of Medan Butterfly pea (Clitoria ternatea L.) corolla extract against Streptococcus mutans ATCC®25175™ and Staphylococcus aureus ATCC®6538™

Isobavachalcone: A comprehensive review of its plant sources, pharmacokinetics, toxicity, pharmacological activities and related molecular mechanisms

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Product

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Antibacterial activity of Medan Butterfly pea (Clitoria ternatea L.) corolla extract against Streptococcus mutans ATCC®25175™ and Staphylococcus aureus ATCC®6538™