Investigation of Phenolic Content, Antioxidant Capacities, Anthelmintic and Cytotoxic Activities of Thymus zygioides Griseb.

Kaska, Arzu; Çiçek, Mehmet; Deniz, Nahide Gülşah; Mammadov, Ramazan

doi:10.9734/jpri/2018/39688

Cited by 8 publications

(7 citation statements)

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“…Stanojevic et al [31] found an EC50 value of 0.743 ± 0.003 mg/mL in their study with the tuber part of the Cyclamen purpurascens Mill. The positive correlation between DPPH and ABTS is in accordance with the report in Kaska et al [32] and Zengin and Aktümsek [33]. In both DPPH and ABTS free radical scavenging activity assays, the activity rate increases in a concentration dependent manner.…”

Section: Resultssupporting

confidence: 91%

Antioxidant and anti-proliferative activities of different parts of Cyclamen cilicium

TURAN

Seçme

Mammadov

2022

Balıkesir Üniversitesi Fen Bilimleri Enstitüsü Dergisi

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This study was designed for investigate of antioxidant, and anti-proliferative activities of acetone, methanol and water extracts of different parts (fresh and underground parts) of Cyclamen cilicium extracts. The antioxidant activities were determined using DPPH, ABTS free radical scavenging activities. Anti-proliferative activities of extracts in Caco-2 colon cancer cells were detected by XTT assay. The determination of contents was evaluated using total phenolics, flavonoid and tannin contents and found maximum values 3.69 ± 0.13 (mg GAE/g-extract), 18.48 ± 0.12 (mg QE/g-extract), 41.17 ± 0.44 (mg CE/g-extract) respectively. C. cilicium extracts exhibited anti-proliferative activity in Caco-2 colon cancer cells. IC50 values of methanol and water extracts of fresh part and water extract of underground part were determined as 35.3276 μg/mL, 42.1831 μg/mL and 64.6144 μg/mL at 24h, respectively. The results showed that C. cilicium is the source of natural antioxidants and may have potential use in pharmaceutical, health, biotechnology, agricultural industry.

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Section: Resultssupporting

confidence: 91%

Antioxidant and anti-proliferative activities of different parts of Cyclamen cilicium

TURAN

Seçme

Mammadov

2022

Balıkesir Üniversitesi Fen Bilimleri Enstitüsü Dergisi

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“…In the literature, biological activities of various extracts of Thymus species have been reported. Kaska et al [15] reported the phenolic content, antioxidant capacities, anthelmintic and cytotoxic activities of ethanol, methanol, acetone and water extracts of T. zygioides Griseb.…”

Section: Resultsmentioning

confidence: 99%

“…There are few reports about chemical compounds and biological activities of various solvent extracts of T. zygioides Griseb [15], T. longicaulis subsp. chaoubardii [16], T. longicaulis subsp.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant activities of aqueous extracts from two Thymus species growing in Turkey Primary tabs

Özer

2020

GSC Biol. and Pharm. Sci.

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In this study, antioxidant activities of aqueous extracts from of Thymus longicaulis subsp. chaubardii (Rchb.f.) Jalas and T. longicaulis subsp. longicaulis C. presl were investigated. Infusion and decoction methods were used to prepare aqueous extracts. 1, 1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging, β-carotene linoleic acid and CUPRAC methods were used to determined antioxidant activities. Aqueous extracts of species exhibited good antioxidant activity. Especially, higher antioxidant capacity was found in decoction extracts compared to infusion extracts for all methods.

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“…Additionally, both extracts recorded higher TFC (57.57-91.86 mg QE/g) than those obtained in the present study. [29] In turn, these values were generally superior to published data of TPC and TFC of methanolic extract of Tunisian T. algeriensis leaf, which were in the range of 14.8-34 mg GAE/g and 3-11 mg RE/g, respectively. [26] In fact, the distribution of phenolic contents varies according to the genotype of plants and depends on many exogenous and endogenous factors.…”

Section: Introductionmentioning

confidence: 56%

“…[ 28 ] Generally, investigations on the chemical composition and biological activities of organic and aqueous extracts from Turkish Thymus species are limited and few studies have been published. [ 29 ] Hence, the present study aimed to investigate the chemical constituents and biological activities of extracts from aerial parts of T. leucostomus H ausskn . & V elen .…”

Section: Introductionmentioning

confidence: 99%

LC‐MS/MS and GC‐MS profiling, antioxidant, enzyme inhibition, and antiproliferative activities of Thymus leucostomus Hausskn. & Velen. extracts

Fayez,

Fahmy,

Zengin

et al. 2023

Archiv der Pharmazie

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The chemical composition as well as antioxidant, antiproliferative, and enzyme inhibition activities of extracts from aerial parts of Thymus leucostomus H ausskn. & V elen. obtained with hexane, methanol, and water were evaluated. Results showed that the methanol extract had significantly (p < 0.05) the highest total phenolic content (TPC; 107.80 mg GAE/g) and total flavonoids content (TFC; 25.21 mg RE/g) followed by the aqueous extract (102.72 mg GAE/g and 20.88 mg RE/g, respectively). LC‐MS/MS‐guided profiling of the three extracts revealed that rosmarinic acid (34.8%), hesperetin (42.9%), and linoleic acid (18%) were the dominant compounds in the methanol, aqueous and hexane extracts, respectively. GC‐MS analysis of the hexane extract showed that ɣ‐sitosterol (29.9%) was the major constituent. The methanol extract displayed significantly (p < 0.05) the highest Cu++, Fe+++, and Mo(VI) ions scavenging and reducing properties while the aqueous extract exerted significantly (p < 0.05) the highest metal chelating power (42.51 mg EDTAE/g). Both the hexane and methanol extracts effectively inhibited the acetylcholinesterase enzyme (2.63 and 2.65 mg GALAE/g, respectively) while the former extract exerted significantly (p < 0.05) the highest butyrylcholinesterase (2.32 mg GALAE/g), tyrosinase (19.73 mg KAE/g), and amylase (1.16 mmol ACAE/g) inhibition capacity. The aqueous extract exhibited the best glucosidase inhibition property (0.49 mmol ACAE/g). The methanol and hexane extracts exerted a higher cytotoxic effect on HT‐29 (IC50: 8.12 µg/mL) and HeLa (IC50 = 8.08 µg/mL) cells, respectively. In conclusion, these results provide valuable insight into the potential use of T. leucostomus bioactive extracts in different pharmaceutical applications.

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Investigation of Phenolic Content, Antioxidant Capacities, Anthelmintic and Cytotoxic Activities of Thymus zygioides Griseb.

Cited by 8 publications

References 0 publications

Antioxidant and anti-proliferative activities of different parts of Cyclamen cilicium

Antioxidant and anti-proliferative activities of different parts of Cyclamen cilicium

Antioxidant activities of aqueous extracts from two Thymus species growing in Turkey Primary tabs

LC‐MS/MS and GC‐MS profiling, antioxidant, enzyme inhibition, and antiproliferative activities of Thymus leucostomus Hausskn. & Velen. extracts

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