Investigation of Anticholinesterase Activity of a Series of Salvia Extracts and the Constituents of Salvia staminea

Topçu, Gülaçtı; Kolak, Ufuk; Öztürk, Mehmet; Boğa, Mehmet; Hatipoglu, Seda Damla; Bahadorı, Fatemeh; Çulhaoğlu, Burcu; Dırmencı, Tuncay

doi:10.2174/2210315511303010003

Cited by 22 publications

(23 citation statements)

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“…In another study, triterpenoids 5 and 6 were found not to be active in the DPPH scavenging activity test assay (Giuseppe et al, 2006). In fact, both triterpenic acids exhibited more or less lipid peroxidation inhibitory activity in several studies, particularly ursolic acid showed higher activity than oleanolic acid (Topcu et al, 2013;Topcu and Kusman, 2014). Compound 7 (bsitosterol) did not show any antioxidant activity in our study correlating to the results in the previous studies (Giuseppe et al, 2006;Hung and Yen 2001).…”

Section: Antioxidant and Anticholinesterase Activitiessupporting

confidence: 88%

Antioxidant and anticholinesterase activities of lupane triterpenoids and other constituents of Salvia trichoclada

et al. 2015

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The methanol extract of the aerial parts of Salvia trichoclada Bentham (Lamiaceae) was studied for bioactive non-volatile secondary metabolites, and nine compounds were isolated. Structures of the isolated compounds were elucidated as lupeol (1), lupenone (2), glochidone (3), monogynol A (4), oleanolic acid (5), ursolic acid (6), b-sitosterol (7), apigenin-7-O-rhamnoside (8), and rosmarinic acid (9) by using 1D and 2D-NMR spectroscopic techniques. A lupane triterpene glochidone was isolated from a Salvia species and Lamiaceae family for the first time in this study. The antioxidant potential of the extract and the isolated compounds were carried out by using lipid peroxidation inhibitory activity (b-carotene bleaching method) and DPPH free radical scavenging activity test assays. Their anticholinesterase activity was investigated by the Ellman method against both acetylcholinesterase (AChE) and butyrylcholinesterase enzymes.Compounds 1, 3, 5, 6, 8 and 9 showed fairly high anticholinesterase activity almost at all concentrations. Among them, a flavone glycoside apigenin-7-O-rhamnoside exhibited the highest and selective AChE inhibitory activity. Glochidone (3) was found to be the most active one among the isolated lupanes, which exhibited a close activity to that of standard compound galanthamine. Among all the tested compounds, rosmarinic acid (9) exhibited highest antioxidant and good anticholinesterase activity.

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Section: Antioxidant and Anticholinesterase Activitiessupporting

confidence: 88%

Antioxidant and anticholinesterase activities of lupane triterpenoids and other constituents of Salvia trichoclada

et al. 2015

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“…In this study, a diterpenoid diglucoside (1) and four flavone glycosides (2)(3)(4)(5) together with 15 known compounds (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20), including two abietane-type diterpenoids (14,15) were obtained as the constituents of aerial parts of C. mongolica collected in Töv Province, Mongolia (Fig. 1).…”

Section: Introductionmentioning

confidence: 99%

“…1). In the last decade, various groups have reported Lamiaceae diterpenoids which have anticholinesterase activities, such as clerodane-type diterpenoids and tetracyclic diterpenoids from Ballota limbata [5], cis-clerodane-type tricyclic diterpenoids from Otostegia limbata [6], ent-kaurane diterpenoids from Isodon wightii and Sideritis arguta and congesta [7][8][9], cryptotanshinone from Salvia miltiorrhiza [10], kabdane-type diterpenoids from Leonurus heterophyllus [11], taxodion and ferruginol from Salvia stamines [12], and sclareol from Salvia chrysophylla [13]. These were mentioned as potent acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors because both AChE and BChE are targets of candidate phytochemicals for the treatment of neurodegenerative disorders such as Alzheimer's disease (AD) because of the cholinergic hypothesis [14].…”

Section: Introductionmentioning

confidence: 99%

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Cholinesterase-inhibitory diterpenoids and chemical constituents from aerial parts of Caryopteris mongolica

et al. 2015

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A diterpenoid diglucoside (12,19-di-O-β-D-glucopyranosyl-11-hydroxyabieta-8,11,13-triene-19-one), isoscutellarein 7-O-[β-D-xylopyranosyl-(1→2)]-β-D-glucopyranoside, isoscutellarein 7-O-[α-L-rhamnopyranosyl-(1→2)]-β-D-glucopyranoside, hypolaetin 7-O-[6″-O-(p-E-coumaroyl)]-β-D-glucopyranoside, hypolaetin 7-O-[6″-O-(E-caffeoyl)]-β-D-glucopyranoside, and 15 known compounds were isolated from aerial parts of the Mongolian medicinal plant Caryopteris mongolica. The cholinesterase-inhibitory activities of the constituents were estimated. The abietane diterpenoids (12-O-demethylcryptojaponol and 6α-hydroxydemethylcryptojaponol) showed potent inhibitory activity against acetylcholinesterase from human erythrocytes and electric eel, and against butyrylcholinesterase from horse serum.

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“…Sages are among the best-known classes for various biological activities [12][13][14]. A great number of the aromatic taxa make Lamiaceae commercially significant, owing to their aromas, infusions, tinctures, and flavors that are used as resources of herbal products [15].…”

Section: Introductionmentioning

confidence: 99%

Essential Oil Composition, Antimicrobial and Antioxidant Activities of Salvia staminea

Çolak¹,

Yıldırım²,

Bozdeveci³

et al. 2017

Rec. Nat. Prod.

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Volatile constituents of the essential oil which was obtained by hydrodistillation (HD) in a Clevengertype apparatus from the air-dried Salvia staminea Montbret & Aucher ex Bentham (Lamiaceae) collected from Bayburt (North East Part of Black Sea Reagan of Turkey), were analyzed by GC-FID and GC-MS. Additionally, volatiles for the whole part of S. staminea were analyzed by two different methods which are headspace (HS)-GC-FID/MS and headspace solid-phase micro extraction (HS-SPME)-GC-FID/MS. As results of this study, thirty compounds from hydrodistillation, fifteen constituents from HS-SPME and two components from headspace of S. staminea were identified with GC-FID/MS. The major compounds identified in the essential oil, SPME and HS of S. staminea were linalyl acetate (23.30%, 85.07%, and 87.55%) and linalool (22.05%, 9.02%, and 12.44%), respectively. The antimicrobial activities of the essential oil of S. staminea were screened against seven microorganisms (Escherichia coli, Yersinia pseudotuberculosis, Staphylococcus aureus, Enterococcus faecalis, Bacillus cereus, Listeria monocytogenes, and Candida albican) and showed good antimicrobial activity against Gram-positive bacteria which is consistent with the literature with the other types of Salvia species. The essential oil of S. staminea showed good antioxidant activity with IC 50 60.4 µg/mL.

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Investigation of Anticholinesterase Activity of a Series of Salvia Extracts and the Constituents of Salvia staminea

Cited by 22 publications

References 0 publications

Antioxidant and anticholinesterase activities of lupane triterpenoids and other constituents of Salvia trichoclada

Antioxidant and anticholinesterase activities of lupane triterpenoids and other constituents of Salvia trichoclada

Cholinesterase-inhibitory diterpenoids and chemical constituents from aerial parts of Caryopteris mongolica

Essential Oil Composition, Antimicrobial and Antioxidant Activities of Salvia staminea

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