Antioxidant and anticholinesterase activities of lupane triterpenoids and other constituents of Salvia trichoclada

Çulhaoğlu, Burcu; Hatipoglu, Seda Damla; Dönmez, Ali A.; Topçu, Gülaçtı

doi:10.1007/s00044-015-1424-7

Cited by 28 publications

(11 citation statements)

References 29 publications

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“…A literature survey showed that 6,7-dehydroroyleanone showed higher DPPH free radical scavenging effect than ABTS cation radical scavenging activity [38], ferruginol possessed high ABTS cation radical scavenging effect [15], β-sitosterol, stigmasterol, lupenone, ursolic and oleanolic acids, and taraxasterol exhibited moderate antioxidant activity in DPPH, ABTS and CUPRAC assays [40,41] as indicated in the current work.…”

Section: Antioxidant Activity Of the Isolated Secondary Metabolitessupporting

confidence: 73%

Bioguided Isolation of Secondary Metabolites from Salvia cerino-pruinosa Rech. f. var. cerino-pruinosa

Ertaş¹,

Cakirca²,

Yener³

et al. 2021

Rec.Nat.Prod.

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In the current study, the ethanol extracts prepared from the aerial parts and roots of an endemic species, Salvia cerino-pruinosa Rech. f. var. cerino-pruinosa were fractionated on silica gel columns and tested for determination of their antioxidant activity using DPPH free radical and ABTS cation radical scavenging, and cupric reducing antioxidant capacity (CUPRAC) test assays. Twenty known secondary metabolites were isolated from the active antioxidant fractions; rosmarinic acid (1), chlorogenic acid (2), caffeic acid (3), 4-hydroxybenzoic acid (4), benzoic acid (5), luteolin 7-O-glucoside (6), bis-(2-ethylhexyl)benzene-1,2-dicarboxylate (7), salvianolic acid A (8), salvianolic acid B (9), 7-acetylroyleanone (10), 6,7-dehydroroyleanone (11), ferruginol (12), inuroyleanol (13), 12-hydroxy-6,7-secoabieta-8,11,13-triene-6,7-dial (14), ursolic acid (15), oleanolic acid (16), taraxasterol (17), lupenone (18), β-sitosterol (19), and stigmasterol (20). Rosmarinic acid, which was obtained from the aerial parts, was found to be the best antioxidant compound among the isolated secondary metabolites in DPPH free radical and ABTS cation radical scavenging, and CUPRAC assays (IC50: 1.20±0.04 µg/mL, IC50: 1.74±0.06 µg/mL, A0.5: 1.22±0.02 µg/mL, respectively). Chlorogenic and caffeic acids, luteolin 7-O-glucoside, salvianolic acids A and B, and inuroyleanol exhibited also high antioxidant activity in the mentioned assays.

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Section: Antioxidant Activity Of the Isolated Secondary Metabolitessupporting

confidence: 73%

Bioguided Isolation of Secondary Metabolites from Salvia cerino-pruinosa Rech. f. var. cerino-pruinosa

Ertaş¹,

Cakirca²,

Yener³

et al. 2021

Rec.Nat.Prod.

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“…In Salvia species, hydrophilic solvents are widely used to extract flavones. For instance, methanolic, ethanolic, and aqueous mixtures have been used to extract various compounds, mostly luteolin and apigenin derivatives, including glucoside and glucuronides, along with hydroxylated and methylated derivatives [36,[82][83][84][85][86][87][88][89][90][91][92]. In contrast, other polar solvents such as acetone and ethyl acetate are less used to extract these compounds [32,37,[93][94][95], while dichloromethane is even less common [96,97].…”

Section: Extraction Methods Of Flavones From Lamiaceae Plants 41 Conventional Methodsmentioning

confidence: 99%

Extraction Processes Affect the Composition and Bioavailability of Flavones from Lamiaceae Plants: A Comprehensive Review

et al. 2021

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Lamiaceae plants are a widespread family of herbaceous plants with around 245 plant genera and nearly 22,576 species distributed in the world. Some of the most representative and widely studied Lamiaceae plants belong to the Ocimum, Origanum, Salvia, and Thymus genera. These plants are a rich source of bioactive molecules such as terpenes, flavonoids, and phenolic acids. In this sense, there is a subgroup of flavonoids classified as flavones. Flavones have antioxidant, anti-inflammatory, anti-cancer, and anti-diabetic potential; thus, efficient extraction techniques from their original plant matrixes have been developed. Currently, conventional extraction methods involving organic solvents are no longer recommended due to their environmental consequences, and new environmentally friendly techniques have been developed. Moreover, once extracted, the bioactivity of flavones is highly linked to their bioavailability, which is often neglected. This review aims to comprehensively gather recent information (2011–2021) regarding extraction techniques and their important relationship with the bioavailability of flavones from Lamiaceae plants including Salvia, Ocimum, Thymus, and Origanum.

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“…ESI‐MS m / z 455.3496 [M‐H] − . It was determined as ursolic acid by comparison with the published data in the literature (Çulhaoğlu et al., 2015).…”

Section: Resultsmentioning

confidence: 99%

Bioassay‐guided isolation of anti‐inflammatory constituents from Celtis sinensis leaves

Fang

Xie

et al. 2020

J. Food Biochem.

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Ginkgo acids (GAs) in ginkgo products usually lead to allergies or liver toxicity. In this study, the GA-induced toxicity was attenuated and Con A-induced T-lymphocyte proliferation was inhibited by extracts of Celtis sinensis leaves (ECSL). So, the active ingredients in ECSL were studied to solve the problems caused by GAs. First, the eight components of MeOH extracts were determined by HPLC-DAD/LC-MS. Then, the 12 active ingredients were separated based on the anti-inflammatory activity. Lymphocyte conversion showed that the inhibition rates of apigenin, quercetin, and isovitexin at 100 μM on Con A-activated proliferation of T cells were up to 82.46%, 62.86% and 42.76%, respectively. The inhibition rate on the LPS-induced NO release in RAW 264.7 cells of quercetin, apigenin, isovitexin, and vitexin were exceeding 80% at 100 μM. Taken together, the material foundation for the screen of GAs toxicityattenuated ingredients were provided here. Practical applications Ginkgo biloba extracts (EGBs) have been conducted to develop functional food which could increase blood circulation and enhance memory. Nevertheless, people in consumption of ginkgo products, often caused severe allergic reactions due to the potential allergens identified ginkgolic acids (GAs) of ginkgo products. We first find that the extracts of Celtis sinensis leaves can reduce GAs-induced damage on HepG2 liver cells. Then, the bioactive compounds in C. sinensis leaves were separated and purified based on anti-inflammatory activities against T cells. Quercetin, apigenin, and isovitexin showed well anti-inflammatory activities against Con A-activated T-lymphocytes and LPS activated RAW 264.7 macrophages. However, quercetin and apigenin are flavones O-glycosides which are rich in Ginkgo biloba. To solve the problems in Ginkgo biloba products caused by GAs, flavone C-glycoside (isovitexin) may be used for the further study in GAs toxicity-reduction.

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Antioxidant and anticholinesterase activities of lupane triterpenoids and other constituents of Salvia trichoclada

Cited by 28 publications

References 29 publications

Bioguided Isolation of Secondary Metabolites from Salvia cerino-pruinosa Rech. f. var. cerino-pruinosa

Bioguided Isolation of Secondary Metabolites from Salvia cerino-pruinosa Rech. f. var. cerino-pruinosa

Extraction Processes Affect the Composition and Bioavailability of Flavones from Lamiaceae Plants: A Comprehensive Review

Bioassay‐guided isolation of anti‐inflammatory constituents from Celtis sinensis leaves

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