Investigating thermal, mechanical and rheological properties of novel antibacterial hybrid nanocomposites based on PLLA/triclosan/nano-hydroxyapatite

Davachi, Seyed Mohammad; Kaffashi, Babak; Torabinejad, Bahman; Zamanian, Ali; Seyfi, Javad; Hejazi, Iman

doi:10.1016/j.polymer.2016.03.007

Cited by 48 publications

(34 citation statements)

References 39 publications

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“…Lack of stress‐shielding through the use of polymeric biomaterials has led to the versatile application in the reconstruction of defect . But in hard tissue regeneration, there is the need to mix with bioactive materials in order to increase their potential for simulation of bone composition and chemical bonding ability with natural bone, mechanical stability, etc. The blending of polymers and ceramics necessitates the development of hybrid biomaterials for simulating multiphase tissue such as bone.…”

Section: Introductionmentioning

confidence: 99%

A novel pathway for in situ synthesis of modified gelatin microspheres by silane coupling agents as a bioactive platform

Ghorbani

Zamanian

Behnamghader

et al. 2018

J of Applied Polymer Sci

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This study investigated the fabrication and modification of gelatin microspheres via single emulsion method and silane coupling agents, respectively. Herein, the influence of oil phase and washing procedure on morphology and uniformity of microspheres was evaluated. The results of field emission scanning electron microscopy indicated a positive effect of olive oil on the production of uniform and approximately mono‐size spheres while monodispersity increased after samples were washed under ultrasonication. Investigation of crosslinking degree demonstrated that GPTMS could not show efficiency as high as glutaraldehyde, but the lack of toxicity and inducing bioactive behavior to the microspheres has made them appropriate for bone applications. Moreover, the stability of spheres after 14 days in phosphate buffered saline proved the ability of (3‐glycidyloxypropyl)trimethoxysilane to crosslink gelatin. The presence of silane coupling agents in prepared spheres caused the biomimetic formation of hydroxyapatite after a 14‐day immersion in simulated body fluid as observed by field emission scanning electron microscopy‐energy‐dispersive X‐ray spectroscopy, changes in pH, Fourier transform infrared spectroscopy, X‐ray diffraction, and atomic force microscopy. Adhesion, spreading, and proliferation of L929 cells on the hybrid microspheres corroborated the potential of gelatin spheres for biomedical application. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46739.

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Section: Introductionmentioning

confidence: 99%

A novel pathway for in situ synthesis of modified gelatin microspheres by silane coupling agents as a bioactive platform

Ghorbani

Zamanian

Behnamghader

et al. 2018

J of Applied Polymer Sci

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“…Hence, nHA is usually combined with biopolymer and organic material into a composite form to overcome the limitations of its mechanical properties. Many studies have been reported on the fabrication of composite scaffolds using nHA with biocompatible polymers, such as poly-L-lactic acid (PLLA) (Davachi et al 2016), poly-L-glycolic acid (PLGA) (Zheng et al 2013), poly(hydroxybutyrate-co-valerate) (PHBV) (Sultana and Wang 2008), cellulose (Zadegan et al 2011), PCL (Hassan et al 2014), and polyvinyl alcohol (PVA) (Sultana and Zainal 2016).…”

Section: Introductionmentioning

confidence: 99%

Characterization, drug loading and antibacterial activity of nanohydroxyapatite/polycaprolactone (nHA/PCL) electrospun membrane

Hassan

Sultana

2017

3 Biotech

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Considering the important factor of bioactive nanohydoxyapatite (nHA) to enhance osteoconductivity or bone-bonding capacity, nHA was incorporated into an electrospun polycaprolactone (PCL) membrane using electrospinning techniques. The viscosity of the PCL and nHA/PCL with different concentrations of nHA was measured and the morphology of the electrospun membranes was compared using a field emission scanning electron microscopy. The water contact angle of the nanofiber determined the wettability of the membranes of different concentrations. The surface roughness of the electrospun nanofibers fabricated from pure PCL and nHA/PCL was determined and compared using atomic force microscopy. Attenuated total reflectance Fourier transform infrared spectroscopy was used to study the chemical bonding of the composite electrospun nanofibers. Beadless nanofibers were achieved after the incorporation of nHA with a diameter of 200-700 nm. Results showed that the fiber diameter and the surface roughness of electrospun nanofibers were significantly increased after the incorporation of nHA. In contrast, the water contact angle (132°± 3.5°) was reduced for PCL membrane after addition of 10% (w/ w) nHA (112°± 3.0°). Ultimate tensile strengths of PCL membrane and 10% (w/w) nHA/PCL membrane were 25.02 ± 2.3 and 18.5 ± 4.4 MPa. A model drug tetracycline hydrochloride was successfully loaded in the membrane and the membrane demonstrated good antibacterial effects against the growth of bacteria by showing inhibition zone for E. coli (2.53 ± 0.06 cm) and B. cereus (2.87 ± 0.06 cm).

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“…It is clear that the crystallization peaks became narrower upon addition of nanoperlite. According to the reported data in Table , the width of half‐height crystallization peak ( WHH) shows a decreasing trend as the nanoperlite increases the rate of crystallization due to the nucleating effect . We postulate that nanoperlite plays two roles in the crystallization of LDPE.…”

Section: Resultsmentioning

confidence: 84%

“…Higher conductivity resulted in easier heat transfer to the bulk of samples. Due to the irregularity of amorphous regions in samples, this region was easier to be thermally decomposed . The final degradation temperature shows an increasing trend for all the samples, due to the more interaction of alkyl groups and nanoperlite, which leads to a higher interaction upon addition of nanoparticles.…”

Section: Resultsmentioning

confidence: 99%

Investigating Thermal and Surface Properties of Low‐Density Polyethylene/Nanoperlite Nanocomposites for Packaging Applications

Heidari¹,

Davachi

Sahraeian

et al. 2018

Polymer Composites

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Nanocomposites films based on low‐density polyethylene (LDPE) and different compositions of treated and untreated nanoperlite were prepared via melt mixing of the ingredients on a corotating twin‐screw extruder and then film blowing the nanocomposites. The physical dispersion of the nanocomposites is confirmed using Fourier transform infrared‐attenuated total reflectance (FTIR‐ATR) method. According to the thermal studies, the nanocomposites with untreated nanoperlite showing higher melting temperature and crystallinity, while their thermal stability is lower than nanocomposites with treated nanoperlite. The thermal and FTIR‐ATR studies also revealed the ethylene absorption of the nanocomposites. According to the surface energy results, the treatment of the nanoparticles completely changes the surface behavior and hydrophobicity of the films. Finally, peel color index and field study observations showed that increase in nanoperlite will increase the shelf life of the fruits; however, the nanocomposite with 6% untreated nanoperlite is the best choice for the packaging applications. POLYM. COMPOS., 40:2929–2937, 2019. © 2018 Society of Plastics Engineers

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Investigating thermal, mechanical and rheological properties of novel antibacterial hybrid nanocomposites based on PLLA/triclosan/nano-hydroxyapatite

Cited by 48 publications

References 39 publications

A novel pathway for in situ synthesis of modified gelatin microspheres by silane coupling agents as a bioactive platform

A novel pathway for in situ synthesis of modified gelatin microspheres by silane coupling agents as a bioactive platform

Characterization, drug loading and antibacterial activity of nanohydroxyapatite/polycaprolactone (nHA/PCL) electrospun membrane

Investigating Thermal and Surface Properties of Low‐Density Polyethylene/Nanoperlite Nanocomposites for Packaging Applications

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