Intrasellar germinoma associated with hyperprolactinemia

Marcovitz, Sorana; Guyda, H.; Finlayson, M. H.; Wee, Roberto; Hardy, Jules

doi:10.1016/0090-3019(84)90145-9

Cited by 10 publications

(1 citation statement)

References 38 publications

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“…Several cases of primary intrasellar germinomas have been reported [5][6][7][8][9][10][11][12][13][14][15][16][17], but non-germinomatous GCT have rarely been described (Table 1) [18][19][20][21][22][23][24]. The main clinical manifestation in GCT arising in the sella turcica is central diabetes insipidus [2,3].…”

Section: Introductionmentioning

confidence: 99%

Sellar and suprasellar mixed germ cell tumor mimicking a pituitary adenoma

et al. 2008

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Germ cell tumors (GCT) are a heterogeneous group of lesions whose origin is not well established. Several cases of primary intrasellar germinomas have been reported, however non-germinomatous GCT have rarely been described. We report the case of a young adult male patient with a mixed GCT that presented with a sellar tumor with suprasellar extension. The patient seeked medical attention because of seizures and magnetic resonance imaging evidenced a tumor of the sellar region. Hyperprolactinemia was also present and dopamine agonist therapy was started. As there was a rapid tumor growth and the patient had concomitant central diabetes insipidus and elevated testosterone levels, a GCT was suspected and confirmed by elevated serum concentration of β-human chorionic gonadotrophin. Patient underwent surgical resection of the tumor and histopathological examination confirmed the diagnosis of a mixed GCT. Chemotherapy was initiated, followed by conventional radiotherapy. In conclusion, although pituitary adenomas respond for the vast majority of sellar tumors, concomitant symptoms such as central diabetes insipidus and rapid tumor growth should raise the suspicion of a diverse diagnosis. The present report intend not only to show a rare case of sellar and suprasellar mixed GCT but also to remind clinicians that if laboratory findings do not fit into patient's diagnosis (such as high testosterone levels in our patient), then the diagnosis should be reviewed.

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Section: Introductionmentioning

confidence: 99%

Sellar and suprasellar mixed germ cell tumor mimicking a pituitary adenoma

et al. 2008

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Magnetic resonance imaging of neurohypophyseal germinomas

Fujisawa

Asato

Okumura

et al. 1991

Cancer

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The authors reviewed magnetic resonance (MR) images in seven cases of germinoma in the hypothalamoneurohypophyseal axis (HNA). The intrasellar portions were clearly identified in six germinomas. Two small germinomas of these six were located only in the neurohypophysis. The major parts of the four large germinomas were located below the optic chiasm, and the large intrasellar portions were demonstrated. The remaining one small germinoma was localized from the pituitary stalk to the third ventricular floor. These findings strongly suggest that the primary site of germinomas in the HNA is the neurohypophysis. In the four large germinomas, the tumor shape was similar to that of pituitary adenoma. The authors believe that age (limited to first three decades), symptoms (diabetes insipidus), MR findings absence of normal hyperintense signal of the posterior pituitary on T1‐weighted (T1W1) images, and homogeneous hypointensity to the pons on T1W1 images/isointensity on T2‐weighted images are important in differential diagnosis.

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