Intraoperative floppy iris syndrome after treatment with duloxetine: Coincidence, association, or causality?

González-Martín-Moro, J.; González‐López, J.J.; Zarallo-Gallardo, J.; Fernández-Miguel, Y.

doi:10.1016/j.oftale.2015.02.008

Cited by 5 publications

(2 citation statements)

References 7 publications

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“…Furthermore, several reports have been published, suggesting an association between IFIS and finasteride, 9,18,19 mianserin, 20 antipsychotic agents, 21 chloropromazine, 22,23 donepezil, 24 quetiapine, 9,25 imipramine, 26 risperidone, 27 duloxetine, 28 warfarin, 29 aspirin, 23 losartan, 23 and metformin. 23 Apart from potential association with the intake of various medications, IFIS has been also noted in patients with hypertension.…”

Section: Introductionmentioning

confidence: 99%

Risk factors for intraoperative floppy iris syndrome: a prospective study

Chatziralli

Peponis

Parikakis

et al. 2016

Eye

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Section: Introductionmentioning

confidence: 99%

Risk factors for intraoperative floppy iris syndrome: a prospective study

Chatziralli

Peponis

Parikakis

et al. 2016

Eye

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“…zuclopentixol [20], chlorpromazine [21], quetiapine [3,22], risperidone [23]); antidepressant (e.g. duloxetine [24], minaserin [25], imipramine [26]); cognition-enhancing agents (e.g. donepezil [27], rivastigmine [3]; and benzodiazepine [3,28,29] There also have been case reports of IFIS in patients using blood thinners (e.g.…”

Section: Other Pharmacologic Agentsmentioning

confidence: 99%

Dealing with floppy iris syndrome

Park

Wilkinson²,

Mamalis³

2021

Current Opinion in Ophthalmology

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Purpose of reviewThe aim of this study was to review and summarize recent findings and advancements regarding intraoperative floppy iris syndrome (IFIS). Although many improvements have been made for the management of IFIS, it remains a challenging condition for surgeons. An understanding of the syndrome as well as the multitude of tools to mitigate risk of complication is important for surgeons operating on highrisk patients. Recent findingsA variety of management approaches have been modified and improved or further supported with new data, such as intracameral compounds, intraoperative devices and surgical techniques. SummaryAn understanding of risk factors is important for the identification of at-risk patients. A variety of approaches can greatly reduce incidence of IFIS complications. Multiple management strategies should be utilized to further reduce risk during these difficult surgeries.

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<p>Intraoperative Floppy Iris Syndrome: Updated Perspectives</p>

Christou¹,

Tsinopoulos²,

Ziakas³

et al. 2020

OPTH

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Almost fifteen years since its initial description, intraoperative floppy iris syndrome (IFIS) during phacoemulsification surgery remains a challenge for cataract surgeons in all its key aspects that include the stratification of the preoperative risk, preoperative prophylaxis treatment, surgery design and intraoperative management. Since its original association with tamsulosin intake, IFIS has been positively correlated with a plethora of risk factors which include: gender, age, hypertension, other a1-adrenergic receptor antagonists, finasteride, angiotensin II receptor inhibitors, benzodiazepines, antipsychotics, hypertension drugs and decreased dilated pupil diameter. The assessment and stratification of the preoperative risk is pivotal in screening patients prone to develop IFIS. For these patients, it is essential that preoperative prophylaxis, employment of necessary measures and surgical technique modifications are considered. A multidisciplinary approach of IFIS is a mandate, thus ophthalmologists, urologists and sometimes other specialties should cooperate to "educate" each other about the risks of their respective fields. They both must be aware of the joint statement on IFIS by the American Academy of Ophthalmology and the American Society of Cataract and Refractive Surgery which suggests either the initiation of tamsulosin after phacoemulsification or the use of a non-selective a1-ARA for benign prostatic hyperplasia treatment. In conclusion, awareness of the risk factors associated with IFIS and their detailed preoperative documentation is crucial in addressing IFIS. The lack of such an awareness can turn a routine, uneventful surgery into one with significant visual morbidity.

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Intraoperative floppy iris syndrome after treatment with duloxetine: Coincidence, association, or causality?

Cited by 5 publications

References 7 publications

Risk factors for intraoperative floppy iris syndrome: a prospective study

Risk factors for intraoperative floppy iris syndrome: a prospective study

Dealing with floppy iris syndrome

<p>Intraoperative Floppy Iris Syndrome: Updated Perspectives</p>

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