Risk factors for intraoperative floppy iris syndrome: a prospective study

Clinical risk factors associated with intraoperative floppy iris syndrome: a prospective study

“…Similar to other results [2,4,10], we found no correlation between the risk of IFIS and each of the following morbidities: diabetes mellitus, glaucoma, and pseudoexfoliation syndrome. However, there are some controversies occurring regarding the relationship between IFIS and high blood pressure.…”

“…In our study, male gender was significantly associated with IFIS in the univariate analysis, but not in the multivariate analysis. Similar results have been published in large prospective studies [2,4]. However, Neff et al [10] described male gender as a statistically significant risk factor for developing IFIS with a calculated OR of 4.7 using multivariate analysis.…”

“…In an experimental study on rabbits, Horvath et al [26] observed an increased risk of iris billowing during some phacoemulsification maneuvers subjects treated with finasteride was similar with those obtained in rabbits treated with tamsulosin. To the best of our knowledge, there are only two large prospective studies in the literature investigating the association between IFIS and finasteride use [4,8]. In our prospective study, the adjusted OR for finasteride use was 3.94 (95% CI 1.32-11.79; P = 0.014).…”

“…In the initial report of intraoperative floppy iris syndrome, Chang and Campbell speculated on the association between IFIS and tamsulosin use [1], which was confirmed in several following publications [2,4,[9][10][11][12]. According to the current literature, the incidence of IFIS is highly variable, and ranges from 0.8 to 12.6% [1][2][3][8][9][10][11][12][13].…”

“…Since 2005, the relationship between IFIS and non-selective alpha1-ARAs, hypertension, and male sex has been also reported [1][2][3]. An association between IFIS and other medications such as finasteride, mianserin, rivastigmine, antipsychotic drugs, and benzodiazepines has also been described [3][4][5].…”