Intradermal metal deposits in an industrial worker

Breier, Friedrich; Loader, Dagmara; Wasilewicz, G.; Brenner, W.; Sator, Paul; Feldmann, Reinhold; Stella, A.; Osterode, W.; Falkenberg, Gerald; Steiner, Albert; Jurecka, Wolfgang

doi:10.1007/s00105-015-3695-9

Cited by 3 publications

(1 citation statement)

References 7 publications

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“…These ndings explained the lack of aberrant nuclei in the crypts of mice exposed to Cr VI . Breier et al 347 studied intradermal metal deposits in an industrial worker, employed for more than 20 years in cutting high-voltage cables without any personal protection. The 2D m-SRXRF measurements of the intradermal deposits showed the elements Cu, Ni, Sr and Zn, to be strongly associated with the S concentrations.…”

Section: Clinicalmentioning

confidence: 99%

2016 Atomic Spectrometry Update – a review of advances in X-ray fluorescence spectrometry and its applications

West¹,

Ellis

Potts

et al. 2016

J. Anal. At. Spectrom.

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Section: Clinicalmentioning

confidence: 99%

2016 Atomic Spectrometry Update – a review of advances in X-ray fluorescence spectrometry and its applications

West¹,

Ellis

Potts

et al. 2016

J. Anal. At. Spectrom.

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Quantitative trace element mapping in liver tissue from patients with Wilson`s disease determined by micro X-ray fluorescence

Osterode

Falkenberg

Ferenci

et al. 2019

Journal of Trace Elements in Medicine and Biology

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Aims of this investigation were to quantify copper (Cu), iron (Fe) and zinc (Zn) along with sulphur (S) and phosphorus (P) in hepatocytes and connective tissue in liver section from patients with Wilson´s disease (WD) by micro Synchrotron X-ray fluorescence (µ-SRXRF). Secondly to establish two-dimensional µ-SRXRF element mappings for comparison with histologically prepared slices, and thirdly to assess whether elemental distributions are associated. Methods: Archival liver tissues from twelve patients with end-stage cirrhosis or fulminant WD were investigated. Mutations in ATP7B have been classified before. For control seven archived normal liver tissues were investigated. µ-SRXRF measurements were performed at the DORIS III storage ring at HASYLAB/DESY (Hamburg, Germany). Two-dimensional element distribution were compared with histologically prepared slices about 20-30µm apart from those investigated by µ-SRXRF. Results: Elementary copper (Cu) could be demonstrated in all investigated liver sections simultaneously with Fe, Zn, P and S. In WD mean Cu was 20 fold increased in hepatocytes and threefold in fibrotic areas in comparison with controls. In regeneration nodules Cu was strikingly inhomogeneous distributed. Cu concentrations measured by µ-SRXRF correlated with those measured by atom absorption spectroscopy. Strong associations in their regional distribution existed between Zn and Cu or Fe and S. Moreover, differences in Cu/S were found between hepatocytes and fibrotic areas. An increase of Fe could only be documented in hepatocytes compared to fibrotic areas. With a beam size of 15x15µm two-dimensional distributions of these elements are morphologically comparable with histological section with a magnification of about 25x optic microscope. Conclusions: µ-SRXRF investigations are a valuable tool for quantifying element concentrations in biological tissues and further provide 2-dimensional information of element distribution and elemental association in a biological tissues, thus speeding up basic knowledge in a synopsis with biological and clinical data.

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Atomic spectrometry update: review of advances in the analysis of clinical and biological materials, foods and beverages

Taylor

Barlow

Day

et al. 2017

J. Anal. At. Spectrom.

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Intradermal metal deposits in an industrial worker

Abstract: To the best of our knowledge, this is the first case report in the dermatological literature of intradermal metal deposits identified via SRXRF analysis.

Cited by 3 publications

References 7 publications

2016 Atomic Spectrometry Update – a review of advances in X-ray fluorescence spectrometry and its applications

2016 Atomic Spectrometry Update – a review of advances in X-ray fluorescence spectrometry and its applications

Quantitative trace element mapping in liver tissue from patients with Wilson`s disease determined by micro X-ray fluorescence

Atomic spectrometry update: review of advances in the analysis of clinical and biological materials, foods and beverages

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