Intra-abdominal adipose tissue deposition and parity

Blaudeau, Tamilane E.; Gr, Hunter; Sirikul, Bovorn

doi:10.1038/sj.ijo.0803252

Cited by 47 publications

(52 citation statements)

References 29 publications

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“…It is suggested that after pregnancy, there is a preference for fat accumulation in the visceral adipose tissue [40]. Similarly, in a sample of 170 American women aged 18-76 years, it has been found that the intra-abdominal fat tissue increased as the number of parturitions increased, regardless of age, body fat percentage, physical activity, and smoking [41].…”

Section: Prevalence Of Abdominal Obesitymentioning

confidence: 97%

Epidemiology of Abdominal Obesity

Olinto¹,

Theodoro²,

Canuto³

2017

Adiposity - Epidemiology and Treatment Modalities

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Abdominal obesity (AO) is associated with endothelial dysfunction, inflammation, insulin resistance, diabetes mellitus, hypercholesterolemia, metabolic syndrome, and cancer. AO is a multifactorial disorder arising from genetic, environmental, socioeconomic, and behavioral factors. Thus, in this chapter, we devote ourselves to the exercise of trying to explain the epidemiology of AO in adults. We showed the increasing prevalence of AO around the world, and a gender difference in this determination was observed. Among women, the population group who is the most affected by AO, a higher prevalence of AO is observed in individuals living in low-or middle-income countries (LMIC), who are older, multiparous, and in the menopausal transition, and who belong to the poorest strata and have lower educational level. While among men, the risk of AO is positively associated with socioeconomic status, particularly in LMIC. Regarding behavioral factors (eating frequency, sleep duration, physical activity, and smoking), gender differences are difficult to be detected due to the lack of studies investigating their association with AO according to sex. However, the current evidence suggests that men benefit more from consuming a greater number of meals a day and women are more affected by the harmful effects of physical inactivity. We argued AO, despite biological conditions associated with behavior factors, should be examined as an important issue of gender inequality in health, possibly mediated by socioeconomic and behavioral differences between men and women.

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Section: Prevalence Of Abdominal Obesitymentioning

confidence: 97%

Epidemiology of Abdominal Obesity

Olinto¹,

Theodoro²,

Canuto³

2017

Adiposity - Epidemiology and Treatment Modalities

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“…It is interesting to note in this context that an association of parity and visceral fat mass has been demonstrated recently. 35 In our study, serum AFABP levels are positively associated with IMT in both genders. However, this association is lost in multivariate analysis adjusting for markers of obesity and renal function.…”

Section: Discussionmentioning

confidence: 63%

Metabolic and genetic predictors of circulating adipocyte fatty acid-binding protein

et al. 2011

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Background: Adipocyte fatty acid-binding protein (AFABP) was recently introduced as a novel adipokine playing an important role in glucose homeostasis. In this study, we investigated the relationship between serum AFABP levels and metabolic, as well as cardiovascular parameters, in the self-contained population of Sorbs. Furthermore, we conducted a genome-wide association study on serum AFABP concentrations in the Sorbs and we separately analyzed the effects of two common variants in the FABP4 gene on AFABP serum concentration. Methods: Serum AFABP concentrations were quantified by enzyme-linked immunosorbent assay and correlated with metabolic and cardiovascular parameters, as well as inflammatory markers and renal function, in 868 well-characterized non-diabetic Sorbs from Germany. Results: Median AFABP serum concentrations were 1.5-fold higher in female subjects (23.03 mg l À1 ) as compared to male subjects (15.86 mg l À1 ). Waist-to-height ratio and glomerular filtration rate were independently associated with AFABP concentrations in multiple regression analysis in both female and male subjects. The genome-wide scan for association of single-nucleotide polymorphisms with serum AFABP levels in the Sorbs revealed 39 loci reaching P-values o10 À4 . Two single-nucleotide polymorphisms, rs16909187 and rs10808846, representing common genetic variation in FABP4 did not show any effect on serum AFABP concentrations in our study cohort. Conclusion: AFABP serum concentrations are determined by parameters of fat distribution, renal function and gender.

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“…32 Previous studies suggest that weight gained in pregnancy and retained after pregnancy includes fat as opposed to lean mass. [33][34][35][36] We did not find a direct association between cumulative pregnancy weight gain and hepatic steatosis, or number of pregnancies and hepatic steatosis, because pregnancy may not lead to significant accumulations of fat in the liver, even as it leads to increased fat mass and visceral fat deposition. Alternatively, it is possible that the associations between pregnancy and increases in hepatic steatosis during the reproductive years are attenuated as women age; in Michigan SWAN, hepatic steatosis was ascertained approximately 8 years after the menopausal transition.…”

Section: Discussionmentioning

confidence: 67%

Reproductive History and Chronic Hepatic Steatosis in the Michigan Study of Women's Health Across the Nation

Kim

Harlow

Kong

et al. 2015

Journal of Women's Health

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Background: Reproductive history, particularly maternal age at most recent birth, may reflect lower risk for chronic disease and mortality due to socioeconomic factors, lifestyle behaviors, or genetics. Reproductive history has not been examined with respect to hepatic steatosis, the most common liver disease in the United States. Our objective was to examine the association between reproductive history and hepatic steatosis. Methods: We examined the association between reproductive history characteristics-specifically age at most recent birth-and the odds of moderate to severe hepatic steatosis using a population-based retrospective cohort study of women who underwent hepatic ultrasound at the Michigan site of the Study of Women's Health Across the Nation (n = 331). Results: Women who gave birth at ‡ 35 years of age comprised 19% of the study population and were similar to other women regarding sociodemographic history and health behaviors. In multivariable analyses adjusting for age, race/ethnicity, chronic disease, and medications associated with hepatic steatosis, age at birth ‡ 35 years was associated with significantly decreased odds of hepatic steatosis (adjusted odds ratio [OR] 0.41, 95% confidence interval [CI] 0.20-0.87), which was attenuated after adjustment for waist circumference (OR 0.51, 95% CI 0.24-1.10). Other reproductive factors including gravidity, parity, miscarriages and abortions, recall of gestational weight gain, breastfeeding, age at first birth, and age at final menstrual period were not associated with hepatic steatosis. Conclusions: Women who were older at their most recent birth had a reduced odds of hepatic steatosis, possibly associated with their lower waist circumference.

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Intra-abdominal adipose tissue deposition and parity

Cited by 47 publications

References 29 publications

Epidemiology of Abdominal Obesity

Epidemiology of Abdominal Obesity

Metabolic and genetic predictors of circulating adipocyte fatty acid-binding protein

Reproductive History and Chronic Hepatic Steatosis in the Michigan Study of Women's Health Across the Nation

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