Intestinal Colonization with Oxalobacter formigenes and its Relation to Urinary Oxalate Excretion in Pediatric Patients with Idiopathic Calcium Urolithiasis

Sikora, Przemysław; Niedźwiadek, Justyna; Mazur, Elżbieta; Paluch-Oleś, Jolanta; Zajączkowska, Małgorzata; Kozioł-Montewka, Maria

doi:10.1016/j.arcmed.2009.05.004

Cited by 9 publications

(3 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In normal adult populations, they range from 38% in the U.S. 7 to 77% in Korea 8 . The reported variation in children is slightly lower, ranging from 26% in Poland 9 to 59% in the Ukraine 10 . It is not known whether the incidence of calcium oxalate stones inversely correlates with OxF status in non-U.S. populations.…”

Section: Commentsmentioning

confidence: 87%

Sensitivity of Human Strains of Oxalobacter formigenes to Commonly Prescribed Antibiotics

Lange

Wood

Wong

et al. 2012

Urology

View full text Add to dashboard Cite

Objective To determine the sensitivity of 4 strains of Oxalobacter formigenes (OxF) found in humans, HC1, Va3, CC13, and OxK, to varying concentrations of commonly-prescribed antibiotics. OxF gut colonization has been associated with a decreased risk of forming recurrent calcium oxalate kidney stones. Methods For each strain and each antibiotic concentration, 100 μL of an overnight culture and 100 μL of the appropriate antibiotic were added to a 7 mL vial of oxalate culture media containing 20 mM oxalate. On the fourth day, vials were visually examined for growth, and a calcium oxalate precipitation test was performed to determine whether OxF grew in the presence of the antibiotic. Results All 4 OxF strains were resistant to amoxicillin, amoxicillin/clavulanate, ceftriaxone, cephalexin, and vancomycin while they were all sensitive to azithromycin, ciprofloxacin, clarithromycin, clindamycin, doxycycline, gentamicin, levofloxacin, metronidazole, and tetracycline. One strain, CC13, was resistant to nitrofurantoin while the others were sensitive. Differences in minimum inhibitory concentration between strains were demonstrated. Conclusions Four human strains of OxF are sensitive to a number of antibiotics commonly utilized in clinical practice; however, minimum inhibitory concentrations differ between strains.

show abstract

Section: Commentsmentioning

confidence: 87%

Sensitivity of Human Strains of Oxalobacter formigenes to Commonly Prescribed Antibiotics

Lange

Wood

Wong

et al. 2012

Urology

View full text Add to dashboard Cite

show abstract

“…It has been demonstrated the ability of O. formigenes to degrade oxalate in the intestine and stimulate its endogenous secretion (7,10). Nevertheless, the absence of intestinal O. formigenes colonization is not the sole cause for stone disease (10)(11)(12). A diversity of gut oxalate-degrading bacteria (ODB) (e.g.…”

Section: Introductionmentioning

confidence: 99%

A potential role of fecal oxalate-degrading activity in oxalate homeostasis in end-stage renal disease patients; a descriptive pilot study

et al. 2021

View full text Add to dashboard Cite

Introduction: End-stage renal disease (ESRD) patients have significant differences in plasma oxalic acid (POx) concentration under the same treatment conditions. Objectives: In the present study, we adopted the method of redoximetric titration with a KMnO4 solution to evaluate the effect of total fecal oxalate-degrading activity (ODA) on oxalate homeostasis in ESRD patients which has never been reported before. Patients and Methods: A total of 56 participants were enrolled in this cross-sectional pilot study, including 24 healthy volunteers (a control reference group) and 32 ESRD patients. Among the ESRD patients, there were 21 hemodialysis (HD) and 11 peritoneal dialysis (PD) patients. Total ODA in fecal samples as well as POx concentration, daily urinary oxalate (UOx) and PD effluent oxalate excretion were determined. Cohen’s d was computed to calculate the effect size using post-hoc analysis. Results: Total ODA in fecal microbiota ranged from -23 to 24%/0.01 g of feces and was statistically higher in healthy volunteers compared with the ESRD patients. The ESRD patients with positive total fecal ODA status had higher UOx excretion level and lower POx concentration compared with the patients with negative total fecal ODA status. Cohen’s d effect size was 1.99 and 1.05, respectively. Total fecal ODA was an independent risk factor associated with POx elevation in the ESRD patients. Conclusion: Our pilot study firstly demonstrated a potential role of total fecal ODA in oxalate homeostasis in ESRD patients. The results might be useful for determining sample size considerations and providing groundwork for future research projects.

show abstract

“…Recently, several studies showed that gut microbiota is essential in renal stone formation ( 22 ). Interestingly, the urinary oxalate level is lower in people colonized with O. formigenes than in those not colonized ( 23 , 24 ). However, probiotics containing O. formigenes cannot decrease urinary oxalate levels significantly ( 25 , 26 ).…”

Section: Introductionmentioning

confidence: 97%

Short-Chain Fatty Acids Reduced Renal Calcium Oxalate Stones by Regulating the Expression of Intestinal Oxalate Transporter SLC26A6

Liu

Jin

et al. 2021

mSystems

View full text Add to dashboard Cite

show abstract

Intestinal Colonization with Oxalobacter formigenes and its Relation to Urinary Oxalate Excretion in Pediatric Patients with Idiopathic Calcium Urolithiasis

Cited by 9 publications

References 36 publications

Sensitivity of Human Strains of Oxalobacter formigenes to Commonly Prescribed Antibiotics

Sensitivity of Human Strains of Oxalobacter formigenes to Commonly Prescribed Antibiotics

A potential role of fecal oxalate-degrading activity in oxalate homeostasis in end-stage renal disease patients; a descriptive pilot study

Short-Chain Fatty Acids Reduced Renal Calcium Oxalate Stones by Regulating the Expression of Intestinal Oxalate Transporter SLC26A6

Contact Info

Product

Resources

About