Short-Chain Fatty Acids Reduced Renal Calcium Oxalate Stones by Regulating the Expression of Intestinal Oxalate Transporter SLC26A6

Liu, Yu; Jin, Xi; Ma, Yucheng; Jian, Zhongyu; Wei, Zhitao; Xiang, Liyuan; Sun, Qun; Qi, Shiqian; Wang, Kun‐Jie; Li, Hong

doi:10.1128/msystems.01045-21

Cited by 24 publications

(16 citation statements)

References 53 publications

(67 reference statements)

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“…The bacterial communities are distinct with an enrichment of the genera Akkermansia, Klebsiella and Enterobacteriaceae and a depletion of the genera Blautia and Roseburia in patients with non-hemodialyzed CKD. Some functions are predicted upward such as the metabolism of tryptophan and phenylalanine and others are predicted downward such as the metabolism of arginine and proline during CKD [ 115 , 116 ]. Patients with end-stage kidney disease on peritoneal dialysis were less likely to have Bifidobacterium catenulatum, Bifidobacterium longum, Bifidobacterium bifidum, Lactobacillus plantarum, Lactobacillus paracasei and Klebsiella pneumoniae than healthy controls [ 117 ].…”

Section: Pet Dog and Human Gut Microbiota In Disease Conditionsmentioning

confidence: 99%

Domestic Environment and Gut Microbiota: Lessons from Pet Dogs

et al. 2022

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Accumulating data show the involvement of intestinal microbiota in the development and maintenance of numerous diseases. Many environmental factors influence the composition and function of the gut microbiota. An animal model subjected to the same environmental constraints that will allow better characterization of the microbiota–host dialogue is awaited. The domestic dog has physiological, dietary and pathological characteristics similar to those of humans and shares the domestic environment and lifestyle of its owner. This review exposes how the domestication of dogs has brought them closer to humans based on their intrinsic and extrinsic similarities which were discerned through examining and comparing the current knowledge and data on the intestinal microbiota of humans and canines in the context of several spontaneous pathologies, including inflammatory bowel disease, obesity and diabetes mellitus.

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Section: Pet Dog and Human Gut Microbiota In Disease Conditionsmentioning

confidence: 99%

Domestic Environment and Gut Microbiota: Lessons from Pet Dogs

et al. 2022

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“…Microbiota is important in the development of urolithiasis. Several studies have reported the effect of microbiota in preventing urinary stone through its metabolites, SCFAs [ 59 ].…”

Section: Short Chain Fatty Acidmentioning

confidence: 99%

Role of microbiome and its metabolite, short chain fatty acid in prostate cancer

Yang

Kim

2023

Investig Clin Urol

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The microbiome which is an assembly of all microbes living inside our bodies performs a major role in maintaining human health and wellness. It has been found that the imbalance of the microbiome can cause various diseases in humans. Similarly, there is growing evidence that the microbiome largely affects a person’s chance of contracting certain cancers and how the disease develops and progresses. Studies have shown that about 15% to 20% of all cancers are caused by microbial pathogens. The prevalence of prostate cancer, which is increasing rapidly in Korea, is related to lifestyle including diet. These diets can alter the gut microbial composition, and the effect of the microbiome on prostate cancer development can be estimated. However, the microbiome associated with prostate cancer has been reported differently according to race. This means that the metabolite rather than the specific microbiome will be important. Short chain fatty acids, metabolites of the microbiome, plays an important role in the action mechanism of the microbiome. Short chain fatty acids play roles such as immunomodulation and inhibition of histone deacetylase. Here, we examined the most up-to-date literature featuring the effects of the microbiome on the risk and pathogenesis of prostate cancer.

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“…Their metabolites were mainly SCFAs [ 72 ]. In an experiment using mice, administration of SCFA reduced the formation of CaOx crystals in kidneys and urinary oxalate levels, but increased SCFA-producing bacteria and SCFA in the colon [ 73 ].…”

Section: Substances Involved In Crosstalkmentioning

confidence: 99%

The Urinary Microbiome; Axis Crosstalk and Short-Chain Fatty Acid

et al. 2022

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Our knowledge that “urine is sterile” is no longer accepted after the development of a next-generation sequencing (NGS) test. Using NGS, microbiota in the human body were discovered, and it is expected that this will improve our understanding of human diseases. However, the mechanism involved in the effect of the microbiome on diseases is still poorly understood. Associations of gut microbiome with diseases have been recently reported. Based on such associations, bladder–gut–brain axis, gut–bladder axis, gut–vagina–bladder axis, and gut–kidney axis as novel mechanisms of action of the microbiome have been suggested. Each axis can influence the development and progression of disease through interactions. In these interactions, metabolites of the microbiome including short-chain fatty acids (SCFA) and the inflammasome play an important role. Inflammasomes are multiprotein oligomers that can initiate inflammatory responses. Inflammasomes can trigger inflammation and pyroptosis and ultimately contribute to disease development. SCFAs play an important role in immune cell migration, cytokine production, and maintenance of cellular homeostasis. Associations of inflammasomes with systemic diseases such as obesity and insulin resistance have been reported. The roles of inflammasomes and SCFAs in kidney, bladder, and prostate diseases have also been revealed recently.

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Short-Chain Fatty Acids Reduced Renal Calcium Oxalate Stones by Regulating the Expression of Intestinal Oxalate Transporter SLC26A6

Cited by 24 publications

References 53 publications

Domestic Environment and Gut Microbiota: Lessons from Pet Dogs

Domestic Environment and Gut Microbiota: Lessons from Pet Dogs

Role of microbiome and its metabolite, short chain fatty acid in prostate cancer

The Urinary Microbiome; Axis Crosstalk and Short-Chain Fatty Acid

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