Role of microbiome and its metabolite, short chain fatty acid in prostate cancer

Yang, Hee Jo; Kim, Jae Heon

doi:10.4111/icu.20220370

Cited by 8 publications

(7 citation statements)

References 74 publications

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“…SCFAs are metabolites of the microbiome that have a role in regulating immunity and inhibiting histone deacetylases [ 56 ]. The production of SCFAs in the gut microbiota is influenced by various host, environmental, dietary, and microbial factors [ 57 ].…”

Section: Discussionmentioning

confidence: 99%

Icaritin-curcumol activates CD8+ T cells through regulation of gut microbiota and the DNMT1/IGFBP2 axis to suppress the development of prostate cancer

Xu,

Li,

Liu

et al. 2024

J Exp Clin Cancer Res

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Background Prostate cancer (PCa) incidence and mortality rates are rising. Our previous research has shown that the combination of icariin (ICA) and curcumol (CUR) induced autophagy and ferroptosis in PCa cells, and altered lipid metabolism. We aimed to further explore the effects of the combination of ICA and CUR on gut microbiota, metabolism, and immunity in PCa. Methods A mouse subcutaneous RM-1 cell tumor model was established. 16 S rRNA sequencing was performed to detect changes in fecal gut microbiota. SCFAs in mouse feces, and the effect of ICA-CUR on T-cell immunity, IGFBP2, and DNMT1 were examined. Fecal microbiota transplantation (FMT) was conducted to explore the mechanism of ICA-CUR. Si-IGFBP2 and si/oe-DNMT1 were transfected into RM-1 and DU145 cells, and the cells were treated with ICA-CUR to investigate the mechanism of ICA-CUR on PCa development. Results After treatment with ICA-CUR, there was a decrease in tumor volume and weight, accompanied by changes in gut microbiota. ICA-CUR affected SCFAs and DNMT1/IGFBP2/EGFR/STAT3/PD-L1 pathway. ICA-CUR increased the positive rates of CD3+CD8+IFN-γ, CD3+CD8+Ki67 cells, and the levels of IFN-γ and IFN-α in the serum. After FMT (with donors from the ICA-CUR group), tumor volume and weight were decreased. SCFAs promote tumor development and the expression of IGFBP2. In vitro, DNMT1/IGFBP2 promotes cell migration and proliferation. ICA-CUR inhibits the expression of DNMT1/IGFBP2. Conclusions ICA-CUR mediates the interaction between gut microbiota and the DNMT1/IGFBP2 axis to inhibit the progression of PCa by regulating immune response and metabolism, suggesting a potential therapeutic strategy for PCa.

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Section: Discussionmentioning

confidence: 99%

Icaritin-curcumol activates CD8+ T cells through regulation of gut microbiota and the DNMT1/IGFBP2 axis to suppress the development of prostate cancer

Xu,

Li,

Liu

et al. 2024

J Exp Clin Cancer Res

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“…These findings imply that SCFAs could be very important in developing PCA. Anaerofilum is protective because it reduces inflammation caused by Alistipes , which produce pro-inflammatory mediators and raise the risk of PCA [ 30 , 36 ].…”

Section: Reviewmentioning

confidence: 99%

Probing the Relationship Between the Human Gut Microbiome and Prospects of Prostate Cancer: A Systematic Review

Makkena,

Jaramillo,

Awosusi

et al. 2023

Cureus

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Prostate neoplasia is one of the most commonly occurring neoplasias in males and has a high mortality rate. Prostate cancer (PCA) risk factors include tall stature, male sex, known family history, obesity, high blood pressure, lack of fitness, higher levels of testosterone for a long time, increasing age, and ethnicity are well known. The association and role of the gut microbiota in different diseases in our body have been highlighted recently. Therefore, finding the influence of gut microbiota on the prostatic cells can be useful for preventing prostatic neoplasia and/or reducing its severity. We aimed to assess its impact on PCA risk. We thoroughly searched databases for the relevant literature for our systematic review. The final research papers analyzed how bacteria played a role in the risk of PCA, either through inflammation or the production of metabolites that increase/decrease the risk of PCA. Based on the studies reviewed, we found that some gut bacteria play a role in the formation of PCA. In contrast, some bacteria can help prevent PCA, but the metabolism of the dietary components is the major factor for PCA.

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“…The gut-microbiota-derived SCFAs contribute to the modulation of HDACs [ 101 ]. In return, this SCFA-mediated HDAC modulation may play a crucial role in cell homeostasis.…”

Section: Microbiome-derived Short-chain Fatty Acids (Scfas)mentioning

confidence: 99%

“…Conversely, research studies have recently reported the association between SCFAs and PCa progression [ 101 ]. For example, Matsushita et al [ 107 ] reported that SCFAs promoted PCa growth through IGF1 signaling in Pten knockout mice [ 107 ].…”

Section: Microbiome-derived Short-chain Fatty Acids (Scfas)mentioning

confidence: 99%

“…As previously mentioned, the microbiome can influence systemic and local immune responses using numerous metabolites including SCFAs [ 111 ]. Despite lack of scientific data in terms of the effect of SCFAs on PCa pathogenesis, studies on other malignancies suggest that SCFAs may have a significant impact on PCa progression [ 101 ]. Therefore, further studies need to be conducted to investigate mediation of SCFAs in PCa to determine their exact roles in PCa pathogenesis and treatment.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

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Dissecting Microbiome-Derived SCFAs in Prostate Cancer: Analyzing Gut Microbiota, Racial Disparities, and Epigenetic Mechanisms

Miya

Marima

Damane

et al. 2023

Cancers

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Prostate cancer (PCa) continues to be the most diagnosed cancer and the second primary cause of fatalities in men globally. There is an abundance of scientific evidence suggesting that the human microbiome, together with its metabolites, plays a crucial role in carcinogenesis and has a significant impact on the efficacy of anticancer interventions in solid and hematological cancers. These anticancer interventions include chemotherapy, immune checkpoint inhibitors, and targeted therapies. Furthermore, the microbiome can influence systemic and local immune responses using numerous metabolites such as short-chain fatty acids (SCFAs). Despite the lack of scientific data in terms of the role of SCFAs in PCa pathogenesis, recent studies show that SCFAs have a profound impact on PCa progression. Several studies have reported racial/ethnic disparities in terms of bacterial content in the gut microbiome and SCFA composition. These studies explored microbiome and SCFA racial/ethnic disparities in cancers such as colorectal, colon, cervical, breast, and endometrial cancer. Notably, there are currently no published studies exploring microbiome/SCFA composition racial disparities and their role in PCa carcinogenesis. This review discusses the potential role of the microbiome in PCa development and progression. The involvement of microbiome-derived SCFAs in facilitating PCa carcinogenesis and their effect on PCa therapeutic response, particularly immunotherapy, are discussed. Racial/ethnic differences in microbiome composition and SCFA content in various cancers are also discussed. Lastly, the effects of SCFAs on PCa progression via epigenetic modifications is also discussed.

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Role of microbiome and its metabolite, short chain fatty acid in prostate cancer

Cited by 8 publications

References 74 publications

Icaritin-curcumol activates CD8+ T cells through regulation of gut microbiota and the DNMT1/IGFBP2 axis to suppress the development of prostate cancer

Icaritin-curcumol activates CD8+ T cells through regulation of gut microbiota and the DNMT1/IGFBP2 axis to suppress the development of prostate cancer

Probing the Relationship Between the Human Gut Microbiome and Prospects of Prostate Cancer: A Systematic Review

Dissecting Microbiome-Derived SCFAs in Prostate Cancer: Analyzing Gut Microbiota, Racial Disparities, and Epigenetic Mechanisms

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