Interventions for treating scabies

Walker, G.B.; Johnstone, PW

doi:10.1002/14651858.cd000320

Cited by 63 publications

(62 citation statements)

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“…On the other hand, oral ivermectin (IV) has also been shown to be effective, but the optimal number of courses is still a matter of some controversy. A recent meta-analysis 5 reported that, to date, there is no conclusive evidence that oral IV is superior to topical preparations for treating common scabies in the community setting.…”

Section: Introductionmentioning

confidence: 99%

Ivermectin versus benzyl benzoate applied once or twice to treat human scabies in Dakar, Senegal: a randomized controlled trial

Caumes

Ndaw

et al. 2009

Bull World Health Org

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Objective To compare the effectiveness of oral ivermectin (IV) and two different modalities of topical benzyl benzoate (BB) for treating scabies in a community setting. Methods The trial included patients aged 5-65 years with scabies who attended the dermatology department at the Institut d'Hygiène Sociale in Dakar, Senegal. The randomized, open trial considered three treatments: a single application of 12.5% BB over 24 hours (BB1 group), two applications of BB, each over 24 hours (BB2 group), and oral IV, 150-200 µg/kg (IV group). The primary endpoint was the disappearance of skin lesions and itching at day 14. If necessary, treatment was repeated and patients were evaluated until cured. Results were analysed on an intention-to-treat basis. A pre-planned intermediate analysis was carried out after the BB1, BB2 and IV groups had recruited 68, 48 and 65 patients, respectively. Findings At day 14, 33 patients (68.8%) in the BB2 group were cured versus 37 (54.4%) in the BB1 group and 16 (24.6%) in the IV group (P < 10 -6 ). Bacterial superinfection occurred more often in the IV group than in the BB1 and BB2 groups combined (28% versus 7.8%, respectively; P = 0.006). At day 28, 46 patients (95.8%) in the BB2 group were cured versus 52 (76.5%) in the BB1 group and 28 (43.1%) in the IV group (P < 10 -5 ). These clear findings prompted early study cessation. Conclusion Topical BB was clearly more effective than oral IV for treating scabies in a Senegalese community.Une traduction en français de ce résumé figure à la fin de l'article. Al final del artículo se facilita una traducción al español. ‫املقالة.‬ ‫لهذه‬ ‫الكامل‬ ‫النص‬ ‫نهاية‬ ‫يف‬ ‫الخالصة‬ ‫لهذه‬ ‫العربية‬ ‫الرتجمة‬

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Section: Introductionmentioning

confidence: 99%

Ivermectin versus benzyl benzoate applied once or twice to treat human scabies in Dakar, Senegal: a randomized controlled trial

Caumes

Ndaw

et al. 2009

Bull World Health Org

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“…Telah dilaporkan terjadinya efek samping dermatitis kontak alergika pada penderita yang menggunakan solusio ini tetapi hal ini jarang terjadi. Penelitian menunjukkan bahwa 383 penderita anak-anak yang menggunakan benzyl benzoate mengalami gangguan neurotoksik (Walker dan Johnstone, 2000). Meskipun gangguan neurotoksik yang timbul tidak dapat disimpulkan sebagai efek samping akibat penggunaan benzyl benzoate, disarankan dalam penggunaannya dilakukan pengenceran untuk menghidari adanya efek samping (McCarthy, et al, 2004).…”

Section: Pengobatanunclassified

“…Efek samping yang mungkin terjadi adalah iritasi kulit, dermatitis alergika yang menimbulkan rasa gatal, terbakar, ditusuk, dan ruam. Belum diketahui keamanannya untuk anak-anak dan wanita hamil (Walker dan Johnstone, 2000).…”

Section: Pengobatanunclassified

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Scabies : Penyebab, Penanganan Dan Pencegahannya

Griana

2013

el–Hayah

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“…Several epizootics of scabies, both due to S. scabiei and N. cati, have demonstrated severe impacts on the size and structure of numerous animal populations (Walton & Holt 2004). Among humans, 300 x 10 6 cases of scabies infestations worldwide occur each year (Walker & Johnstone 2000). In some less developed areas, scabies represent a considerable public health problem, with higher prevalence than diarrhea and upper respiratory diseases (Anonymous 2000).…”

Section: Introductionmentioning

confidence: 99%

The taxonomy, life cycle and pathology of Sarcoptes scabiei and Notoedres cati (Acarina, Sarcoptidae): A review in a Fennoscandian wildlife perspective

et al. 2015

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Mites constitute an old cosmopolitan group, abundant in various terrestrial and aquatic habitats of considerable environmental variations. The majority of mites are free-living, whereas some have evolved parasitic relationships with a variety of animals either as endo-or ectoparasites. The ectoparasitic and skin burrowing Sarcoptes scabiei and Notoedres cati, cause sarcoptic and notoedric mange among a variety of mammalian species, including humans. In a non-adequate host these mites lead to pseudo-scabies which is often self-curable. The aim of this review is to provide an overview of recent knowledge on the taxonomy, life cycles and pathology of these two mites, which are of relevance to Fennoscandian wildlife, by considering knowledge on transmission vectors, host immunology, and some documented outbreaks. These mites affect the health and survival of mammals in four ways; 1) skin tissue damages, 2) loss of body fluids, 3) allergic reactions and 4) secondary bacterial infections. A short-term effect of outbreaks is usually high mortality, and long-term effects vary from extinction to biased population structure to no effect at all. Red foxes are generalist predators that are important end-hosts for mites that develop disease depending on their immunity status, and transmit mites to other hosts. Outbreaks of mange may possibly have ecological consequences on a wider scale. In an endangered species, like the arctic fox or Eurasian lynx, loss of only a few individuals can be critical. It might be wise for management authorities to develop emergency plans to minimize consequences of outbreaks of sarcoptic or notoedric mange in threatened species such as the arctic fox and the lynx.

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Interventions for treating scabies

Cited by 63 publications

References 64 publications

Ivermectin versus benzyl benzoate applied once or twice to treat human scabies in Dakar, Senegal: a randomized controlled trial

Ivermectin versus benzyl benzoate applied once or twice to treat human scabies in Dakar, Senegal: a randomized controlled trial

Scabies : Penyebab, Penanganan Dan Pencegahannya

The taxonomy, life cycle and pathology of Sarcoptes scabiei and Notoedres cati (Acarina, Sarcoptidae): A review in a Fennoscandian wildlife perspective

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