Interleukin‐10 gene polymorphisms and chronic periodontitis susceptibility: Evidence based on 33 studies

Abstract

The purpose of the meta-analysis was to investigate the potential association of interleukin-10 (IL-10) polymorphisms with susceptibility to chronic periodontitis (CP). A total of 33 studies involving 3487 cases and 4356 controls were identified through a search of multiple electronic databases (last search was updated on 19 July 2018).Three single nucleotide polymorphisms (SNPs) were included in the meta-analysis: -1082A>G(rs1800896), -819C>T(rs1800871), and -592C>A(rs1800872). Odds ratios (ORs) and their 95% confidence intervals (CIs) using allele, dominant, and recessive genetic models were computed to assess the strength of the association. The -1082A>G(rs1800896) polymorphism was found to be associated with decreased CP risk in both Caucasians and Latinos under the dominant model. The -819C>T(rs1800871) and -592C>A(rs1800872) polymorphisms were both associated with increased CP risk in Latinos under the allele and dominant models. In Asians, no associations were observed for any of the polymorphisms under all comparison models. The present meta-analysis suggests that the -1082A>G(rs1800896) polymorphism might be a protective factor for CP in both Caucasians and Latinos, but the -819C>T(rs1800871) and -592C>A(rs1800872) polymorphisms might contribute to CP pathogenesis in Latinos. K E Y W O R D S IL-10, meta-analysis, periodontitis, polymorphism, susceptibility S U PP O RTI N GI N FO R M ATI O N Additional supporting information may be found online in the Supporting Information section at the end of the article. Howtocitethisarticle: Zhang Z, Zheng Y, Li X. Interleukin-10 gene polymorphisms and chronic periodontitis susceptibility: Evidence based on 33 studies. J Periodont Res. 2019;54:95-105. https://doi.

Periodontal health and disease: The contribution of genetics

“…−819 C/T, also displayed an association with chronic periodontitis in Caucasians and Latinos. 61,62 Additionally, single nucleotide polymorphism IL-10 −1082 A/G was associated with health in both of the same populations. 62 A study of Germans diagnosed with aggressive periodontitis found an association with single nucleotide polymorphism IL-10 rs61815643 and rs6667202.…”

“…61,62 Additionally, single nucleotide polymorphism IL-10 −1082 A/G was associated with health in both of the same populations. 62 A study of Germans diagnosed with aggressive periodontitis found an association with single nucleotide polymorphism IL-10 rs61815643 and rs6667202. 63 A validation study in Polish and German-Austrian populations confirmed these associations 63 .…”

Lack of Association between Interleukin-1βGene Polymorphism (rs16944) and Chronic Periodontitis: From a Case-Control Studies to an Updated Meta-Analysis

“…A total of 457 studies were screened using the mentioned search strategy. After deleting duplicates, a record screen was performed and 16 case-control studies were finally selected [17–31]. The search process and strategy of study selection are showed in Figure 1.…”

“…The characteristics of selected studies in meta-analysis, including our case-control study, are showed in Table 2 [31]. A total of 16 studies were included in the present meta-analysis.…”

Cytokines and Their Genetic Polymorphisms Related to Periodontal Disease

“…In a meta-analysis, Wang et al indicated that the −592C/A IL-10 gene polymorphism is related to PD susceptibility in Caucasians and Asians [50]. Another meta-analysis has shown that the −1082A/G polymorphism might be protective against CP in both Caucasians and Latinos, but the −819C/T and −592C/A polymorphisms might increase the risk of CP in Latinos [49].…”