Periodontal health and disease: The contribution of genetics

Shaddox, Luciana M.; Morford, Lorri A.; Nibali, Luigi

doi:10.1111/prd.12357

Cited by 44 publications

(38 citation statements)

References 166 publications

(262 reference statements)

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“…denticola in healthy Czech patients with periodontitis and in those with type 1 diabetes mellitus and periodontitis, respectively [ 20 ]. This is in line with a suspected role for these genes, involved in the host response, in disease predisposition [ 40 ].…”

Section: Discussionsupporting

confidence: 74%

“…IL4 haplotypes were associated with levels of A. actinomycetemcomitans before and after periodontal treatment [37] while IL17A polymorphism was associated with increased counts of T. forsythia and T. denticola in healthy Czech patients with periodontitis and in those with type 1 diabetes mellitus and periodontitis, respectively [20]. This is in line with a suspected role for these genes, involved in the host response, in disease predisposition [40].…”

Section: Discussionmentioning

confidence: 65%

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Periodontal infectogenomics: a systematic review update of associations between host genetic variants and subgingival microbial detection

et al. 2022

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Objective The aim of this study was to systematically update the evidence for associations between host genetic variants and subgingival microbial detection and counts. Materials and methods Following a previous systematic review (Nibali et al. J Clin Periodontol 43(11): 889-900, 15), an update of a systematic search of the literature was conducted in Ovid Medline, Embase, LILACS, and Cochrane Library for studies reporting data on host genetic variants and detection of microbes subgingivally published in the last 6 years. Results A total of 19 studies were included in the review, from an initial search of 2797 titles. Studies consisted mainly of candidate gene studies and of one genome-wide analysis. A total of 62 studies were considered for summary findings, including 43 identified in the previous systematic review of studies published up to 2015. Meta-analyses were done when appropriate including both papers in the original review and in the update. Meta-analyses revealed lack of associations between IL1 composite genotype and subgingival detection of Aggregatibacter acinomycetemcomitans, Poprhyromonas gingivalis, Tannerella forsythia, Treponema denticola, and Prevotella intermedia. Promising evidence is emerging from other genetic variants and from sub-analyses of data from genome-association studies. Among other studies with candidate-gene, target SNPs were mainly within the IL10, IL6, IL4, IL8, IL17A, and VDR gene. Conclusions IL1 composite genotype does not seem to be associated with subgingival microbial detection. Promising associations should be pursued by future studies, including studies employing -OMICS technologies. Clinical relevance A better knowledge of which host genetic variant predispose to subgingival microbial colonization and to the development of progression of periodontal disease could potentially help to better understand periodontal disease pathogenesis and help with its management.

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Section: Discussionsupporting

confidence: 74%

Section: Discussionmentioning

confidence: 65%

Periodontal infectogenomics: a systematic review update of associations between host genetic variants and subgingival microbial detection

et al. 2022

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“…Genetic factors associated with the susceptibility, severity and the evolution of periodontitis have pointed out to a number of variants in genes of interest (Haworth et al, 2021 ; Shaddox et al, 2021 ). Relevant associations have been found, for instance, in genetic polymorphisms in genes such as IL1B, IL1RN, FcγRIIIb, VDR, and TLR4 in connection to susceptibility to aggressive periodontitis; and in IL1B, IL1RN, IL6, IL10, VDR, CD14, TLR4, and MMP-1 related to chronic periodontitis (Laine et al, 2012 ).…”

Section: Biological Aspects Of Periodontal Inflammationmentioning

confidence: 99%

Periodontal Inflammation and Systemic Diseases: An Overview

2021

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Periodontitis is a common inflammatory disease of infectious origins that often evolves into a chronic condition. Aside from its importance as a stomatologic ailment, chronic periodontitis has gained relevance since it has been shown that it can develop into a systemic condition characterized by unresolved hyper-inflammation, disruption of the innate and adaptive immune system, dysbiosis of the oral, gut and other location's microbiota and other system-wide alterations that may cause, coexist or aggravate other health issues associated to elevated morbi-mortality. The relationships between the infectious, immune, inflammatory, and systemic features of periodontitis and its many related diseases are far from being fully understood and are indeed still debated. However, to date, a large body of evidence on the different biological, clinical, and policy-enabling sources of information, is available. The aim of the present work is to summarize many of these sources of information and contextualize them under a systemic inflammation framework that may set the basis to an integral vision, useful for basic, clinical, and therapeutic goals.

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“…The retrospective nature of the present retrospective study may in uence our explanation of the data. Apart from the age-related orthodontic events may affect alveolar bone remodeling, periodontal disease history, oral hygiene motivation, sex hormone and medication may signi cantly impact periodontal status during orthodontic treatment [31] . We excluded the in uence the sex and ethnicity by recruiting girls younger than 16 years old in the adolescent group, and females older than 18 years to minimize in uence of growth in the adult group.…”

Section: Discussionmentioning

confidence: 99%

Difference in the Alveolar Bone Remodeling Between the Adolescents and Adults During Upper Incisor Retraction: a Retrospective Study

Zheng

Zhu

et al. 2021

Preprint

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Background: The purpose of this study was to compare the difference of alveolar bone remodeling between the adolescents and adults in the maxillary incisor area during retraction. Methods: This retrospective study included 72 female patients who needed moderate anchorage to correct the bimaxillary protrusion. Subjects were further divided into the minor group (n=36, 11-16 years old) and adult group (n=36, 18-35 years old). Digital lateral cephalography and cone beam CT scanning were taken in each patient before (T0) and after treatment (T1). Cephalometry was conducted to assess incisor retraction, while alveolar bone thickness (ABT), alveolar bone distance (ABD, and alveolar bone area (ABA) were detected to assess changes in the alveolar bone. Results: No difference in the inclination of upper incisors was observed at both T0 and T1. Changes in the alveolar bone showed a similar tendency with bone apposition on the labial side and resorption on the palatal side. Less increase in the labial ABT (T1-T0) and more decrease in the palatal ABT (T1-T0) was found in the adult group, leading to less total ABT in the adult group. Higher reduction inn ABD (T1-T0) was found in the adult group. Moreover, more decrease in the ABA (T1-T0) was found in the adult group. Conclusion: When compared adolescents, adult patients have less alveolar bone support after orthodontic treatment, showing a through-the-bone remodeling pattern. Orthodontic should take the age into consideration to reduce the potential periodontal risks during treatment planning.

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Periodontal health and disease: The contribution of genetics

Cited by 44 publications

References 166 publications

Periodontal infectogenomics: a systematic review update of associations between host genetic variants and subgingival microbial detection

Periodontal infectogenomics: a systematic review update of associations between host genetic variants and subgingival microbial detection

Periodontal Inflammation and Systemic Diseases: An Overview

Difference in the Alveolar Bone Remodeling Between the Adolescents and Adults During Upper Incisor Retraction: a Retrospective Study

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