Interface dermatitis

Joshi, Rajiv V.

doi:10.4103/0378-6323.110780

Cited by 40 publications

(35 citation statements)

References 4 publications

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“…The term ''interface dermatitis" refers to the findings in skin biopsy of inflammatory infiltrate that obscures the dermo-epidermal junction. Interface functions as single anatomico-physiological unit and pathological alterations in any of the component of interface result in changes that can affect all its components (Joshi, 2013). There are various disorders with interface changes like early cutaneous T cell lymphoma (mycosis fungoides), vacuolar interface dermatoses etc.…”

Section: Introductionmentioning

confidence: 99%

Clinico-histopathological correlation for diagnosis of lichenoid interface dermatoses

Maheshwari¹,

Mehta²,

Nikam³

2016

Journal of Dermatology & Dermatologic Surgery

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Context: Lichenoid interface dermatitis refers to the histological pattern which is useful for the classification and diagnosis of disorders of a particular group in dermatology with peculiar features.Aims: To get clinico pathological correlation in lichenoid interface dermatitis which will help in accurate diagnosis by analyzing history, clinical examination as well as histological details of nature and extent of epidermal, interface and dermal changes and the distribution of various inflammatory cell infiltrates.Methods: After appropriate case selection according to the inclusion criteria, the biopsy was taken and sent for histopathological analysis. It was reviewed and correlation was done in each patient.Statistical analysis used: kappa correlation analysis. Results: Out of total 117 cases, 108 were of lichen planus, five were of lichen striatus, two of lichenoid drug eruptions and two of lichen nitidus. Clinico-pathological correlation was present in 70.94% of cases of lichenoid interface dermatitis. Correlation was seen in 100% cases of lichen striatus, and 78% cases of lichen planus.Conclusions: The most consistent findings in histology in our study were basement membrane degeneration, band like lymphocytic infiltrates and melanin incontinence. Other findings such as hypergranulosis, civatte bodies were not observed frequently.

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Section: Introductionmentioning

confidence: 99%

Clinico-histopathological correlation for diagnosis of lichenoid interface dermatoses

Maheshwari¹,

Mehta²,

Nikam³

2016

Journal of Dermatology & Dermatologic Surgery

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“…Inflammatory diseases often present in many forms, from occasional rashes accompanied by skin itching and redness, to chronic conditions such as psoriasis, eczema, lichen planus and discoid lupus erythematosus (LED). Within each of these pathologies, there are some similar clinical and histopathological appearances and aetiologies, which have been widely studied and characterised …”

Section: Introductionmentioning

confidence: 99%

Ex vivo fluorescence confocal microscopy for intraoperative, real‐time diagnosis of cutaneous inflammatory diseases: A preliminary study

Bertoni

Azzoni

Reggiani

et al. 2018

Experimental Dermatology

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Ex vivo fluorescence confocal microscopy (FCM) is an innovative imaging tool that can be used intraoperatively to obtain real-time images of untreated excised tissue with almost histologic resolution. As inflammatory diseases often share overlapping clinical features, histopathology evaluation is required for dubious cases, delaying definitive diagnoses, and therefore therapy. This study identifies key-features at ex vivo FCM for differential diagnoses of cutaneous inflammatory diseases, in particular, psoriasis, eczema, lichen planus and discoid lupus erythematosus. Retrospective ex vivo FCM and histological evaluations with relevant diagnoses were correlated with prospectively reported histopathologic diagnoses, to evaluate agreement and the level of expertise required for correct diagnoses. We demonstrated that ex vivo FCM enabled the distinction of the main inflammatory features in most cases, providing a substantial concordance to histopathologic diagnoses. Moreover, ex vivo FCM and histological evaluations reached a substantial agreement with histopathologic diagnoses both for all raters and for each operator. After a yet to be defined learning curve, these preliminary results suggest that dermatologists may be able to satisfactorily interpret ex vivo FCM images for correct real-time diagnoses. Despite some limitations mainly related to the equipment of FCM with a single objective lens, our study suggests that ex vivo FCM seems a promising tool in assisting diagnoses of cutaneous inflammatory lesions, with a level of accuracy quite close to that offered by histopathology. This is the first study to investigate ex vivo FCM application in cutaneous inflammatory lesions, and to evaluate the diagnostic capability of this technology.

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“…Basal cell vacuolization, apoptotic keratinocytes and obscuring of the DEJ by inflammatory cells are the hallmark of primary changes found in this entity. Lupus erythematosus, lichen planus, dermatomyositis, graft versus host disease, erythema multiforme, fixed drug eruptions, lichen striatus, and pityriasis lichenoides are considered as major interface diseases [1]. Little literature is available regarding the in vivo reflectance confocal microscopy (RCM) features of interface dermatitis.…”

Section: Figmentioning

confidence: 99%

Signet Ring-Like Cells: A New Reflectance Confocal Microscopy Clue of Interface Dermatitis Correlated to Basal Cell Vacuolization in Histopathology

Amini‐Adlé¹,

Debarbieux²,

Perier‐Muzet³

et al. 2015

Dermatology

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Interface dermatitis

Cited by 40 publications

References 4 publications

Clinico-histopathological correlation for diagnosis of lichenoid interface dermatoses

Clinico-histopathological correlation for diagnosis of lichenoid interface dermatoses

Ex vivo fluorescence confocal microscopy for intraoperative, real‐time diagnosis of cutaneous inflammatory diseases: A preliminary study

Signet Ring-Like Cells: A New Reflectance Confocal Microscopy Clue of Interface Dermatitis Correlated to Basal Cell Vacuolization in Histopathology

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