Clinico-histopathological correlation for diagnosis of lichenoid interface dermatoses

Maheshwari, Gargi R.; Mehta, Hita; Nikam, Vivek V

doi:10.1016/j.jdds.2015.11.006

Cited by 4 publications

(9 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These studies also reported good number of cases with acanthosis, hypergranulosis and elongation of rete ridges. 2,5,6,7,9,12 However, hyperkeratosis followed by acanthosis was the most common epidermal change seen in study conducted by Maheshwari et al 4 Histological findings of present study were in concordance with these studies.…”

Section: Histological Changessupporting

confidence: 90%

“…Various studies have described band like inflammatory infiltrates hugging the dermoepidermal junction ranging from 48.48 to 100% of the cases as seen in our study as well. 2,[4][5][6][7]12 Similar to present study, perifollicular infiltrates have been described in the lesions of lichen planopilaris. Inflammatory infiltrates at the base of rete ridges are classically seen in hypertrophic lichen planus.…”

Section: Pattern Of Inflammatory Infiltratessupporting

confidence: 82%

“…In present study, out of 135 cases, only 5 patients presented with extra-cutaneous lesions. Oral cavity involvement was 15.38% and genital lesions in 6.84% of cases in study conducted by Maheshwari et al 4 Oral lesions were seen in 16.66% cases of lichenoid eruptions in the study conducted by Chauhan et al 6 Parihar et al reported 3.5% cases of lichen planus with nail involvement. 9 Garg et al, has reported mucosal involvement in 24% and nail involvement in 17.3% cases of lichen planus.…”

Section: Extrcutaneous Involvementmentioning

confidence: 93%

“…Other studies have described nearly equal or more predilection for females. [2][3][4][5][6][7][8][9] A higher predilection of males for the disease could be because of either some geographical variation altering the environmental factors or because of inhibition of many females from reporting for treatment due to the social stigma associated with any skin disease. lichen planus pigmentosus as the second most common variant.…”

Section: Sex Distributionmentioning

confidence: 99%

“…2,5,7 However, study conducted Chauhan et al, and Maheshwari et al, have shown pigment incontinence in 63.63% and 52.14% of the cases respectively. 4,6…”

Section: Histological Changesmentioning

confidence: 99%

See 4 more Smart Citations

A clinico-pathological study of lichenoid tissue reactions/interface dermatitis

2019

View full text Add to dashboard Cite

Background: Lichenoid tissue reaction/Interface dermatitis (LTR/ID) refers to a number of clinically diverse, poorly understood and relatively uncommon inflammatory skin diseases. This study was done to understand the histopathological features of lichenoid tissue reactions in skin biopsies and to assess the concordance and disparity between the clinical and histopathological diagnosis of variants of the same.Methods: It was a 3½ years study from January 2014 to June 2017 in the department of Pathology, KIMS, Hubballi. The present study included skin biopsies of clinically diagnosed and suspected cases and histologically diagnosed cases of LTRs. Skin biopsies received were routinely paraffin processed and H&E stained to study the microscopic features.Results: Out of 166 skin biopsies studied, 148 were histologically confirmed as LTR with majority being of lichen planus (LP) (91.22%). Classical lichen planus was the most common variant of lichen planus among lichen planus cases. Male:female ratio was 1.2:1. Clinico-pathological concordance was seen in 88.55% of the cases.Conclusions: Though definite diagnosis can be made on histopathological examination, size of specimen, site of biopsy, nature and depth of biopsy, quality of sections, treatment history and inter-observer variation (both clinically and histologically) should be kept in mind which may lead to clinicopathological discordance.

show abstract

Section: Histological Changessupporting

confidence: 90%

Section: Pattern Of Inflammatory Infiltratessupporting

confidence: 82%

Section: Extrcutaneous Involvementmentioning

confidence: 93%

Section: Sex Distributionmentioning

confidence: 99%

“…2,5,7 However, study conducted Chauhan et al, and Maheshwari et al, have shown pigment incontinence in 63.63% and 52.14% of the cases respectively. 4,6…”

Section: Histological Changesmentioning

confidence: 99%

See 3 more Smart Citations

A clinico-pathological study of lichenoid tissue reactions/interface dermatitis

2019

View full text Add to dashboard Cite

show abstract

Pattern-Specific Loss of Desmoplakin I and II Immunoreactivity in Erythema Multiforme and its Variants: A Possible Aid in Histologic Diagnosis

Forrester

Tran

Hein³

et al. 2020

The American Journal of Dermatopathology

View full text Add to dashboard Cite

Erythema multiforme (EM), Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) comprise a family of mucocutaneous diseases associated with significant morbidity and mortality. Previous studies have confirmed the presence of autoantibodies to desmoplakin (Dp) I and II in patients with EM, SJS, and TEN. Truncated Dp production leads to characteristic changes visible on light microscopy: perinuclear clumping of keratin filaments and dyskeratotic keratinocyte. Based on these observations, the question arises as to whether a loss of Dp immunoreactivity in skin biopsies could serve as a diagnostic marker of EM, SJS, and TEN. This study analyzed Dp immunostaining patterns in 20 patients with EM or SJS/TEN. To assess the specificity of this approach, Dp immunostaining was also performed on specimens from patients with 5 potential histologic mimics of EM, SJS, and TEN. All of the samples from patients with EM, SJS, and TEN demonstrated absent or markedly diminished staining for Dp. A χ2 test demonstrated a statistically significant difference between the staining patterns in EM, SJS, and TEN and each of the other diagnostic groups that were investigated. This is the first report demonstrating statistically significant specificity of Dp staining patterns in EM/SJS/TEN as compared with other interface dermatitides.

show abstract

Histomorphological study of lichenoid dermatitides – A retrospective study

et al. 2023

View full text Add to dashboard Cite

Background: Lichenoid dermatitis is a very common dermatological condition and is defined by features of basal cell damage and a dense band-like infiltration at the dermo-epidermal junction. There is a wide range of lesions included under this and the prototype lesion is Lichen Planus. Aims and Objectives: The aims of this study were to study the histopathological spectrum of the conditions with lichenoid tissue reaction and to find clinicopathological concordance of the lichenoid lesions. Materials and Methods: A retrospective study was conducted in a tertiary care center, where all the skin biopsy cases diagnosed clinically and/or histologically as lichenoid dermatitis for 2 years (2018–2019) were included in the study. Demographic details, clinical diagnosis, histological diagnosis, and the different histological features were collected from the respective case sheets and biopsy reports and entered in an excel worksheet. Frequency and percentages were used to represent the data. Results: A total of 47 cases were clinically diagnosed as lichenoid dermatitis, of which 38 cases showed concordance between clinical and histopathological diagnosis. Nine cases showed discordance between clinical and histopathological diagnosis and were categorized as lesions without lichenoid features. Seven cases were diagnosed as lichenoid dermatitis only on the histopathological study with an absence of such a differential diagnosis clinically. Out of the total 45 cases diagnosed as lichenoid dermatitis, 27 were lichen planus, five were lichen planus pigmentosus, four were hypertrophic lichen planus, three were lichenoid dermatitis, and two cases each of lichen planopilaris, lichen keratosis, and lichen sclerosis. Lichenoid dermatitis was seen commonly among the 41–50 years age group. Females were more commonly affected than males. Conclusion: Lichen planus is the prototype lesion among the lichenoid dermatitides. Definitive diagnosis of the specific entity among the lichenoid lesions is important as decision-making regarding the treatment modality and prognosis of the patient depends on it. Histopathological examination is vital for the definitive diagnosis, along with clinical correlation which concludes that clinicopathological correlation is the key.

show abstract

Clinico-histopathological correlation for diagnosis of lichenoid interface dermatoses

Cited by 4 publications

References 8 publications

A clinico-pathological study of lichenoid tissue reactions/interface dermatitis

A clinico-pathological study of lichenoid tissue reactions/interface dermatitis

Pattern-Specific Loss of Desmoplakin I and II Immunoreactivity in Erythema Multiforme and its Variants: A Possible Aid in Histologic Diagnosis

Histomorphological study of lichenoid dermatitides – A retrospective study

Contact Info

Product

Resources

About