A clinico-pathological study of lichenoid tissue reactions/interface dermatitis

Dixit, Deepti; Vernekar, Sunita S.; Giriyan, Sujata S.

doi:10.18203/2320-6012.ijrms20191302

Cited by 4 publications

(9 citation statements)

References 8 publications

(50 reference statements)

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“…Among LP and its variants-classical lichen planus was the most common. This is in concordance with the studies done by Kumar et al, Chauhan et al and Dixit et al 5,8,14 Lichen planopilaris was the second most common LP variant in our study followed by lichen planus pigmentosus and hypertrophic LP with equal frequency. But other studies like Chauhan et al and Banushree et al reported lichen planus pigmentosus as the second most common LP variant.…”

Section: Spectrum Of Diseases Under Interface Dermatitissupporting

confidence: 94%

“…7 In this study, the most common site involved was legs (49%). This is similar to studies done by Dixit et al, Khaled et al, and Parihar et al [14][15][16]…”

Section: Correlation Of Clinical and Histopathological Diagnosissupporting

confidence: 92%

“…Dixit et al reported 4.06% cases of interface dermatitis were using bronchodilators/oral contraceptives/antiepileptics. 14 Manjunatha et al also reported 3.33% cases with positive history of drug intake. 7 In this study, the most common site involved was legs (49%).…”

Section: Correlation Of Clinical and Histopathological Diagnosismentioning

confidence: 93%

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A clinicopathological study on interface dermatitis

et al. 2022

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Background: Diagnosis of skin disorders that exhibit interface dermatitis is challenging in few scenarios. Despite sincere efforts, clinical examination per se can help us reach a handsome of differential diagnosis but not a gunshot specific diagnosis. Dermatopathology acts as a saviour to clinicians in such cases. Though histopathology is the gold standard, still one cannot make a “specific” diagnosis by histopathology alone because many have overlapping features. Therefore, the present study aims at the importance of clinicopathological correlation. The objectives were to study the clinical and histopathological features of various dermatoses, which exhibit interface dermatitis histopathologically and estimate clinicopathological concordance.Methods: This was a cross-sectional study done on 50 patients attending outpatient department (OPD), with the lesions suggestive of dermatoses known to exhibit interface dermatitis histologically. Strobe guidelines were followed. After a thorough clinical examination, punch biopsies were done and observed microscopically to detect interface dermatitis, if present. Secondary pathological features were studied to assess clinicopathological concordance. Microsoft excel and statistical package for the social sciences (SPSS) 21.0 were used for data analysis.Results: 76.74% cases were cases of lichen planus and its variants. The most common clinical presentation was papules. Among microscopic features, predominant finding was basal cell vacuolar change in epidermis (97.70% cases). Clinicopathological concordance was seen in 43 cases (83%). 7 cases were diagnosed solely based on histological correlation.Conclusions: A myriad of dermatoses exhibit interface dermatitis as a primary pathological feature. Only an apt correlation of clinical features with secondary pathological features can lead to a specific diagnosis from a bunch of differential diagnoses.

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Section: Spectrum Of Diseases Under Interface Dermatitissupporting

confidence: 94%

“…7 In this study, the most common site involved was legs (49%). This is similar to studies done by Dixit et al, Khaled et al, and Parihar et al [14][15][16]…”

Section: Correlation Of Clinical and Histopathological Diagnosissupporting

confidence: 92%

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A clinicopathological study on interface dermatitis

et al. 2022

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“…The mean age of patients was 43.02 years while the mean age was below 43 years in CLP and over 42 years in OLP. Numerous similar studies have reported LP being more common in women (15)(16)(17), although few studies have found that LP is more prevalent in men (13,18,19). The age category of patients in most studies was the fifth and sixth decades of life, and the mean age in the studies of Pakfetrat et al, Ramalingam et al and Silverman et al were reported to be 41.6, 43.2 and 52 years, respectively, similar to our results (13,20,21).…”

Section: Discussionsupporting

confidence: 90%

Evaluation of mast cell count in oral and cutaneous lichen planus lesions

et al. 2021

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Introduction: Lichen planus (LP) is a relatively common chronic mucocutaneous disorder diagnosed based on clinical manifestations and histopathological findings. Mast cells (MCs) are multifunctional immune cells that are involved in the pathogenesis of LP by releasing certain chemical mediators. Objectives: The purpose of this comparative study was to estimate the number of intact (granulated), degranulated and total MCs in oral lichen planus (OLP) and cutaneous lichen planus (CLP) lesions. Patients and Methods: The present descriptive-analytical and cross-sectional study was conducted on 125 LP blocks, including 40 OLP samples and 85 CLP samples. The mean number of granulated, degranulated and total MCs were counted under light microscope (×100 and ×400). Data were analyzed by SPSS version 24 software using Mann-Whitney U and Pearson’s chi-square tests. Results: The mean total MC count was 14.92 ± 3.90 in OLP samples and 14.04 ± 5.60 in CLP samples respectively which was not statistically significant. The mean granulated MC count in CLP (10.53 ± 5.70) was higher than in OLP (4.34 ± 3.46) (P<0.001). The mean degranulated MC count in OLP (10.57 ± 2.99) was higher than in CLP (3.51 ± 2.72) (P<0.001). Conclusion: No statistically significant difference was observed in the total MC count between OLP and CLP; however the difference in the degranulated MC count was detected between OLP and CLP. Despite the homogeneity in the total MC count, the MCs appear to play different pathological roles in OLP and CLP.

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“…2 Findings such as infiltrates of neutrophils, eosinophils, and plasma cells are rare but may still be seen in lichenoid tissue reactions. 8,12 Additional findings of hyalinized vessels and sub-epidermal extravasation of erythrocytes may be seen in purpuric lichen nitidus. In our patient, such changes were attributed to thrombocytopenia, a common finding in acute myeloid leukemia.…”

Section: Discussionmentioning

confidence: 99%

Generalized Purpuric Lichen Nitidus in a 32-Year-Old Filipino Male with Acute Myeloid Leukemia: Case Report

Escandor

Tan

et al. 2021

Acta Med Philipp

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A 32-year-old Filipino male managed as a case of acute myeloid leukemia presented with a 6-month history of generalized, red-brown papules. After chemotherapy, the patient was advised 30-minutes daily sun exposure as a form of natural phototherapy. On follow-up, most lesions flattened. This case demonstrates chemotherapy's potential role in controlling the patient's inflammatory state and using ultraviolet light therapy in the form of sunlight to manage generalized purpuric lichen nitidus.

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A clinico-pathological study of lichenoid tissue reactions/interface dermatitis

Cited by 4 publications

References 8 publications

A clinicopathological study on interface dermatitis

A clinicopathological study on interface dermatitis

Evaluation of mast cell count in oral and cutaneous lichen planus lesions

Generalized Purpuric Lichen Nitidus in a 32-Year-Old Filipino Male with Acute Myeloid Leukemia: Case Report

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