Inter-eye osmolarity differences in patients with symptomatic and non-symptomatic
            dry eyes

Pena-Verdeal, Hugo; García-Resúa, Carlos; Vazquez-Sanchez, Covadonga; Garcia-Queiruga, Jacobo; Giráldez, María Jesús; Yebra‐Pimentel, Eva

doi:10.5935/0004-2749.20200024

Cited by 9 publications

(11 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Tear film osmolarity was measured with the TearLab (Turkera Medical, http://trukera.com/tearlab/) by determining the electrical impedance. The same TearLab card lot numbers were used to avoid possible variation 23 . TMH images were captured using a Topcon DC‐4 camera (Topcon Healthcare, http://topconhealthcare.eu/en_EU/products/dc-4) attached to a Topcon SL‐D4 slit lamp (http://topconhealthcare.eu/en_EU/products/sl-d4) using illumination from a Keeler Tearscope Plus (http://keeler.co.uk) interferometer 24,25 .…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Assessing neophyte response to daily disposable silicone hydrogel contact lenses: A randomised clinical trial investigation over one month

Garcia‐Queiruga,

Pena‐Verdeal,

Ferreiro‐Figueiras

et al. 2024

Ophthalmic Physiologic Optic

View full text Add to dashboard Cite

ObjectiveThis randomised clinical trial assessed the impact on symptoms, tear film dynamics and ocular surface integrity of daily disposable silicone‐hydrogel contact lenses (CLs) over a month, paying special attention to lid wiper epitheliopathy (LWE) and its implications for CL discomfort.MethodsNeophyte CL wearers (n = 44, 21.09 ± 5.00 years old) were randomly assigned to either the experimental (n = 24) or control group (n = 20). Participants assigned to the experimental group were required to wear daily disposable CLs for 1 month for at least 8 h/day and 6 days/week. All participants were healthy subjects (no history of ocular surgery or active ocular disease) with spherical refractive errors between −8.00 and +5.00 D and cylindrical power <0.75 D. At the baseline and 1‐month sessions, the Dry Eye Questionnaire 5 (DEQ‐5) was completed, together with the measurement of tear film osmolarity with the TearLab osmometer, tear meniscus height (TMH) and lipid layer pattern (LLP) using a slit‐lamp with Tearscope Plus attached, fluorescein break‐up time (FBUT), maximum blink interval (MBI), corneal staining with fluorescein under cobalt blue light and LWE with lissamine green under slit lamp and halogen white light.ResultsAt the baseline session, LWE showed a negative correlation with DEQ‐5 (r = −0.37, p = 0.02). Significant differences in FBUT and LWE (p = 0.04) and a positive correlation between LWE and DEQ‐5 (r = 0.49, p = 0.007) were observed at 1 month. Intrasession analysis at 1 month showed significant differences between the experimental and control groups in DEQ‐5, FBUT and LWE (all p ≤ 0.02). Intersession analysis in the experimental group showed variations in DEQ‐5, FBUT and LWE (all p ≤ 0.02) but no significant variation in the control group (all p ≥ 0.11).ConclusionThe presence of LWE was significantly correlated with higher symptom values in the DEQ‐5. Also, participants in the experimental group presented higher values of LWE after 1 month of CL wear, in comparison with the control group.

show abstract

Section: Methodsmentioning

confidence: 99%

“…The same TearLab card lot numbers were used to avoid possible variation. 23 TMH images were captured using a Topcon DC-4 camera (Topcon Healthcare, topco nheal thcare. eu/ en_ EU/ produ cts/ dc-4) attached to a Topcon SL-D4 slit lamp (topco nheal thcare.…”

Section: Tear Film and Ocular Surface Parametersmentioning

confidence: 99%

Assessing neophyte response to daily disposable silicone hydrogel contact lenses: A randomised clinical trial investigation over one month

Garcia‐Queiruga,

Pena‐Verdeal,

Ferreiro‐Figueiras

et al. 2024

Ophthalmic Physiologic Optic

View full text Add to dashboard Cite

show abstract

“…23 The exclusion criteria were as follows: history of conjunctival, scleral, or corneal disease, previous diagnosis of dry eye disease or glaucoma, a history of ocular surgery and/or, diabetes mellitus, thyroid disorders, hypersensitivity or allergy to anesthesia, and/or systemic disorders that could affect the measurements. 21,24 No participant was under any type of topical and systemic treatment or used artificial tears at the time of the study. Current CL wearers, all of them users of spherical and/or low-astigmatism soft CL, were asked not to wear their CL on the previous 24 hr of the examination.…”

Section: Methodsmentioning

confidence: 99%

Comparison Between Ocular Biometric Parameters and Intraocular Pressure With and Without Contact Lenses

Noya-Padin,

Nores-Palmas,

Giraldez

et al. 2023

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

Self Cite

View full text Add to dashboard Cite

Objectives: To compare the values of central corneal thickness, anterior chamber depth (ACD), lens thickness (LT), vitreous length (VL), axial length (AL), and corneal-compensated intraocular pressure performed with and without contact lenses (CL). Methods: Forty volunteer participants (16 men and 24 women, 24.2±2.9 years) were recruited. In a single visit, participants underwent autorefraction, keratometry, biometry, topography, pachymetry, and tonometry with the naked eye (without CL). Then, biometry, pachymetry, and tonometry were repeated twice wearing two CL (somofilcon A and nesofilcon A) fitted in a random order. Results: Many of the ocular biometric values were affected by the use of CL during measurements (paired t test; all P≤0.003), except for LT and VL (Wilcoxon test; both P≥0.272). Corneal-compensated intraocular pressure was also affected by contact lens wear during measurements, obtaining lower values when wearing them (Wilcoxon test; all P≤0.001). Conclusions: Central corneal thickness, ACD, AL, and corneal-compensated intraocular pressure measurements cannot be performed while wearing CL. However, LT and VL measurements were not affected by any contact lens use. In addition, it was observed that ACD results from both devices are not interchangeable either when measured with the naked eye or using any contact lens.

show abstract

“…5 We located three studies that attempted to correlate inter-eye osmolarity differences with DED symptoms and other non-osmolar signs. [8][9][10] None of these studies have studied the inter-eye osmolarity difference as an independent diagnostic criterion.…”

Section: Introductionmentioning

confidence: 99%

“…6 The importance of inter-eye differences is previously studied Pena-Verdeal et al who looked at the criterion of intereye difference independently of high osmolarity. 8 However, they looked at inter-eye difference as one group, including the patients with high osmolarity (309 mOsmol/L or higher from either eye). These subjects would have been classified as hyperosmolar on that basis.…”

mentioning

confidence: 99%

The Significance of Inter-Eye Osmolarity Difference in Dry Eye Diagnostics

Nilsen¹,

Jensen²,

Gundersen³

et al. 2023

OPTH

View full text Add to dashboard Cite

The purpose of this study was to evaluate the diagnostic value of inter-eye osmolarity differences in relation to dry eye symptoms and other non-osmolar signs of dry eye disease. Patients and Methods: One hundred ninety one participants who attended a larger interventional study of dry eye disease prior to and after cataract surgery were analyzed for dry eye disease (DED). Dry eye diagnostics were performed for all subjects according to the DEWS II criteria: tear osmolarity was collected from both eyes with the TearLab system, non-invasive Tear film break up time (NIKBUT) was obtained on the test eye with Keratograph and ocular surface staining (OSS) was evaluated using the Oxford schema. The Ocular Surface Disease Index (OSDI) questionnaire was used to assess symptoms. Inter-eye osmolarity greater than 8, which is considered as a sign of DED according to the TearLab user manual, was evaluated and compared with other non-osmolar signs of DED. Results: The 191 subjects were divided into three groups according to osmolarity measurements. Sixty-five subjects had normal osmolarity (below 308 mOsmol/L in both eyes and less than 9 mOsmol/L difference between the eyes), 107 had high osmolarity (308 mOsmol/L or higher in one of the eyes) and 19 had an inter-eye difference >8 mOsmol/L or higher, with neither eye having osmolarity higher than 307 mOsmol/L. Signs and symptoms in this last group were not correlated with the high osmolarity group or the normal group, though they appeared more similar to the normal group. Conclusion:The diagnostic value of inter-eye osmolarity difference in predicting symptoms or other non-osmolar signs of dry eyes appears weak. Our study suggests that the criterion of an inter-eye difference of 8 mOsmol/L is not a useful cut-off for diagnosing dry eyes based on osmolarity.

show abstract

Inter-eye osmolarity differences in patients with symptomatic and non-symptomatic dry eyes

Cited by 9 publications

References 0 publications

Assessing neophyte response to daily disposable silicone hydrogel contact lenses: A randomised clinical trial investigation over one month

Assessing neophyte response to daily disposable silicone hydrogel contact lenses: A randomised clinical trial investigation over one month

Comparison Between Ocular Biometric Parameters and Intraocular Pressure With and Without Contact Lenses

The Significance of Inter-Eye Osmolarity Difference in Dry Eye Diagnostics

Contact Info

Product

Resources

About