2023
DOI: 10.2147/opth.s402556
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The Significance of Inter-Eye Osmolarity Difference in Dry Eye Diagnostics

Abstract: The purpose of this study was to evaluate the diagnostic value of inter-eye osmolarity differences in relation to dry eye symptoms and other non-osmolar signs of dry eye disease. Patients and Methods: One hundred ninety one participants who attended a larger interventional study of dry eye disease prior to and after cataract surgery were analyzed for dry eye disease (DED). Dry eye diagnostics were performed for all subjects according to the DEWS II criteria: tear osmolarity was collected from both eyes with th… Show more

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Cited by 4 publications
(2 citation statements)
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“…An Oculus Keratograph 5 M (Oculus Optikgeräte, Wetzlar, Germany) was used to perform meibography, measurement of tear meniscus height and non-contact break-up time (NBUT). Meibomian gland drop-out (meiboscore) was assessed from infrared images of the upper and lower eyelids (Ocular Keratograph 5 M), and the images were graded as previously described (Graae Jensen et al, 2023). Grade 0 represented no loss of meibomian glands, grade 1; <1/3 of glands lost, grade 2; 1/3-2/3 glands lost and grade 3; >2/3 glands lost.…”
Section: Samplesmentioning
confidence: 99%
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“…An Oculus Keratograph 5 M (Oculus Optikgeräte, Wetzlar, Germany) was used to perform meibography, measurement of tear meniscus height and non-contact break-up time (NBUT). Meibomian gland drop-out (meiboscore) was assessed from infrared images of the upper and lower eyelids (Ocular Keratograph 5 M), and the images were graded as previously described (Graae Jensen et al, 2023). Grade 0 represented no loss of meibomian glands, grade 1; <1/3 of glands lost, grade 2; 1/3-2/3 glands lost and grade 3; >2/3 glands lost.…”
Section: Samplesmentioning
confidence: 99%
“…Grade 0 represented no loss of meibomian glands, grade 1; <1/3 of glands lost, grade 2; 1/3-2/3 glands lost and grade 3; >2/3 glands lost. NBUT was measured as previously described (Graae Jensen et al, 2023;Malmin et al, 2023). To assess NBUT, patients were instructed to blink twice and then refrain from blinking for as long as possible, but maximally for 24 s. After the second blink, the measurement started automatically and disruption of the tear film was detected automatically by the Oculus Keratography 5 M. NBUT was measured three times and the average value was used.…”
Section: Samplesmentioning
confidence: 99%