Injectable Self-Healing Hydrogel with Antimicrobial and Antifouling Properties

Li, Lin; Yan, Bin; Yang, Jianguo; Huang, Weijuan; Zeng, Hongbo

doi:10.1021/acsami.6b16192

Cited by 154 publications

(112 citation statements)

References 30 publications

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“…As an example, an irregular wound resulting from a foot ulcer is shown; in such cases, it is typically difficult for the vessels to grow in (Scheme 1c), which may be overcome in our proposed formulation. Furthermore, no self-healing hydrogels have been reported to include intrinsic structural properties that promote angiogenesis while simultaneously preventing bacterial infections [15][16][17] . We anticipate that such unique multifunctional hydrogels will exhibit efficient anti-infective abilities, enhance angiogenic activity, and subsequently accelerate tissue healing in diabetic skin wound sites (Scheme 1d).…”

Section: Introductionmentioning

confidence: 99%

An injectable self-healing coordinative hydrogel with antibacterial and angiogenic properties for diabetic skin wound repair

et al. 2019

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We report here an injectable, self-healing coordinative hydrogel with antibacterial and angiogenic properties for diabetic wound regeneration. The hydrogel was prepared by coordinative cross-linking of multi-arm thiolated polyethylene glycol (SH-PEG) with silver nitrate (AgNO3). Due to the dynamic nature of Ag-S coordination bond and bacteria-killing activity of Ag+, the resultant coordinative hydrogel featured self-healing, injectable and antibacterial properties. In this study, we synchronously loaded an angiogenic drug, desferrioxamine (DFO), in the coordinative hydrogel during cross-linking. We finally obtained a multifunctional hydrogel that is manageable, resistant to mechanical irritation, antibacterial and angiogenic in vitro. Our in vivo studies further demonstrated that the injectable self-healing hydrogel could efficiently repair diabetic skin wounds with low bacteria-infection and enhance angiogenic activity. In short, besides diabetic skin wound repair, such dynamic multifunctional hydrogel scaffolds would show great promise in the regeneration of different types of exposed wounds, in particular, in situations with disturbed physiological functions, high risk of bacterial infections, and external mechanical irritation.

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Section: Introductionmentioning

confidence: 99%

An injectable self-healing coordinative hydrogel with antibacterial and angiogenic properties for diabetic skin wound repair

et al. 2019

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“…10,11 Although the traditional dressing has some advantages for wound healing, it is not suitable for large areas and irregular wounds because of lack of environmental sensitivity, especially thermo-sensitivity. If the hydrogels are sensitive to temperature, they can have many advantages for clinical applications, such as flexibility and injectability 12,13 and similarity to the extracellular matrix for supporting cell attachment, proliferation, migration as well as differentiation. 14 Poly(N-isopropyl-acrylamide) (PNIPAM) has attracted wide attention because of its sensitivity to temperature, 15 especially in the field of biomedicine.…”

Section: Introductionmentioning

confidence: 99%

<p>Poly(N-Isopropyl-Acrylamide)/Poly(γ-Glutamic Acid) Thermo-Sensitive Hydrogels Loaded with Superoxide Dismutase for Wound Dressing Application</p>

Dong¹,

Zhuang²,

Hao³

et al. 2020

IJN

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Introduction: Chronic trauma repair is an important issue affecting people's healthy lives. Thermo-sensitive hydrogel is injectable in situ and can be used to treat large-area wounds. In addition, antioxidants play important roles in promoting wound repair. Methods: The purpose of this research was to prepare a novel thermo-sensitive hydrogelpoly(N-isopropyl-acrylamide)/poly(γ-glutamic acid) (PP) loaded with superoxide dismutase (SOD) to improve the effect for trauma treatment. The micromorphology of the hydrogel was observed by scanning electron microscope and the physical properties were measured. The biocompatibility of hydrogel was evaluated by MTT experiment, and the effect of hydrogel on skin wound healing was evaluated by in vivo histological staining. Results: Gelling behavior and differential scanning calorimeter outcomes showed that the PP hydrogels possessed thermo-sensitivity at physiological temperature and the phase transformation temperature was 28.2°C. The high swelling rate and good water retention were conducive to wound healing. The activity of SOD in vitro was up to 85% at 10 h, which was advantageous to eliminate the superoxide anion. MTT assay revealed that this hydrogel possessed good biocompatibility. Dressings of PP loaded with SOD (SOD-PP) had a higher wound closure rate than other treatments in vivo in diabetic rat model. Discussion: The SOD-PP thermo-sensitive hydrogels can effectively promote wound healing and have good application prospects for wound repair.

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“…To test the injectable ability of SB hydrogels after employing double Schiff base linkage, the shear rate‐dependent viscosities of hydrogel I and hydrogel II were comparatively studied. As shown in Figure , the viscosities of hydrogel I and hydrogel II decreased sharply as the shear rate increased, which indicated good shear‐shinning properties for both hydrogel I and hydrogel II . It means that the double Schiff base linkage does not deteriorate the injectable ability of SB hydrogels.…”

Section: Resultsmentioning

confidence: 84%

Enhancing the Stability of Hydrogels by Doubling the Schiff Base Linkages

Ding

Gao

Xiao

et al. 2018

Macro Chemistry & Physics

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Schiff base bonds formed by primary amines and aldehydes are attractive for the construction of self‐healing and injectable hydrogels. However, biomedical applications of the Schiff base–based (SB) hydrogels are usually limited by their inherent low stability due to the rapid exchange dynamic of the Schiff base bond under physiological condition. Herein, a general method to improve the stability of SB hydrogels by simply doubling the Schiff base linkages at the cross‐linking points is proposed. The hydrogels formed by single Schiff base linkage (hydrogel I) disorganize into nano‐aggregates due to the rapid exchange dynamic of Schiff base bond, while the hydrogels formed by double Schiff base linkage (hydrogel II) maintain the gel network for longer times due to the improved stability of the double Schiff base linkage at cross‐linking points. Moreover, the hydrogel II displays excellent self‐healing and injectable properties due to the rapid dynamic nature of Schiff base bonds.

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Injectable Self-Healing Hydrogel with Antimicrobial and Antifouling Properties

Cited by 154 publications

References 30 publications

An injectable self-healing coordinative hydrogel with antibacterial and angiogenic properties for diabetic skin wound repair

An injectable self-healing coordinative hydrogel with antibacterial and angiogenic properties for diabetic skin wound repair

<p>Poly(N-Isopropyl-Acrylamide)/Poly(γ-Glutamic Acid) Thermo-Sensitive Hydrogels Loaded with Superoxide Dismutase for Wound Dressing Application</p>

Enhancing the Stability of Hydrogels by Doubling the Schiff Base Linkages

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