We demonstrate a novel strategy enabling the use of a continuous-wave diode near-infrared (NIR) laser to disrupt block copolymer (BCP) micelles and trigger the release of their "payloads". By encapsulating NaYF(4):TmYb upconverting nanoparticles (UCNPs) inside micelles of poly(ethylene oxide)-block-poly(4,5-dimethoxy-2-nitrobenzyl methacrylate) and exposing the micellar solution to 980 nm light, photons in the UV region are emitted by the UCNPs, which in turn are absorbed by o-nitrobenzyl groups on the micelle core-forming block, activating the photocleavage reaction and leading to the dissociation of BCP micelles and release of co-loaded hydrophobic species. Our strategy of using UCNPs as an internal UV or visible light source upon NIR light excitation represents a general and efficient method to circumvent the need for UV or visible light excitation that is a common drawback for light-responsive polymeric systems developed for potential biomedical applications.
A novel mussel-inspired injectable hydrogel with self-healing and anti-biofouling capabilities is developed and it possesses great potential as a drug-delivery carrier. The hydrogel can heal autonomously from repeated structural damage and also effectively prevent non-specific cell attachment and biofilm formation.
Using a photosensitive hybrid hydrogel loaded with upconversion nanoparticles (UCNPs), we show that continuous-wave near-infrared (NIR) light (980 nm) can be used to induce the gel-sol transition and release large, inactive biomacromolecules (protein and enzyme) entrapped in the hydrogel into aqueous solution "on demand", where their bioactivity is recovered. This study is a new demonstration and development in harnessing the unique multiphoton effect of UCNPs for photosensitive materials of biomedical interest.
We report a facile method to synthesize Fe3O4@polydopamine (PDA)-Ag core-shell microspheres. Ag nanoparticles (NPs) are deposited on PDA surfaces via in situ reduction by mussel-inspired PDA layers. High catalytic activity and fast adsorption of a model dye methylene blue (MB) at different pH values are achieved mainly due to the presence of monodisperse Ag NPs and electrostatic interactions between PDA and MB. The as-prepared Fe3O4@PDA-Ag microspheres also show high cyclic stability (>27 cycles), good acid stability, and fast regeneration ability, which can be achieved efficiently within several minutes by using NaBH4 as the desorption agent, showing great potentials in a wide range of applications.
Poly(vinylidene
fluoride) (PVDF)-based piezoelectric materials
are promising candidates for sensors, transducers, and actuators,
due to several distinctive characteristics such as good flexibility,
easy processability, and high mechanical resistance. In the present
work, PVDF-based nanocomposites loaded with BaTiO3 nanoparticles
(NPs) of various weight fractions were prepared by the electrospinning
technique and used for the fabrication of a flexible piezoelectric
pressure tactile sensor (PPTS). The addition (5, 10, and 20 wt %)
of piezoelectric BaTiO3 NPs improves the piezoelectric
performance, especially the β phase crystals of PVDF/BaTiO3 (10 wt %) nanocomposites that can reach 91.0%. In addition,
the mechanical strength of PVDF/BaTiO3 nanocomposites is
up to 26.7 MPa, which is an increase of 66% compared to neat PVDF.
It should be emphasized that the elongation at break continuously
increases from 71% to 153% with increasing BaTiO3 NPs.
More importantly, the PPTS (piezoelectric pressure tactile sensor)
with the combination of electrospun PVDF/BaTiO3 nanocomposite
membranes and polydimethylsiloxane (PDMS) displays excellent flexibility
and linear response to external mechanical force. The flexible PPTS
devices capable of detecting different music sounds have potential
uses in wide fields, such as voice recognition, speech therapy, and
ultrasound imaging.
Microbial adhesion, biofilm formation and associated microbial infection are common challenges faced by implanted biomaterials (e.g., hydrogels) in bioengineering applications. In this work, an injectable self-healing hydrogel with antimicrobial and antifouling properties was prepared through self-assembly of an ABA triblock copolymer employing catechol functionalized polyethylene glycol (PEG) as A block and poly{[2-(methacryloyloxy)-ethyl] trimethylammonium iodide}(PMETA) as B block. This hydrogel exhibits excellent thermosensitivity, and can effectively inhibit the growth of E. coli (>99.8% killing efficiency) and prevent cell attachment. It can also heal autonomously from repeated damage, through mussel-inspired catechol-mediated hydrogen bonding and aromatic interactions, exhibiting great potential in bioengineering applications.
A stretchable transparent double network ionogel composed of physically cross-linked poly(vinylidene fluoride-co-hexafluoropropylene) (P(VDFco-HFP)) and chemically cross-linked poly(methyl methacrylate-co-butylmethacrylate) (P(MMA-co-BMA)) elastomer networks within [EMIM][TFSI] ionic liquid was fabricated through a facile one-pot thermal polymerization. The dualnetwork (DN) ionogel presents good mechanical performance (failure tensile stress 2.31 MPa, strain 307%) with a high loading of ionic liquid (70 wt %) for achieving required ionic conductivity (>0.1 S/m at room temperature). The transparent chemical cross-linked P(MMA-co-BMA) elastomer network endows high transparency (>93%) and high stretchability to the DN ionogel. The DN ionogel maintains good toughness, elasticity, and transparency in a wide temperature range (−40 to 80 °C) for the application in a harsh environment. In addition, the sensitivity of the DN ionogel to the change of environment temperature and deformation was detected and described. The practical potential of the DN ionogel in flexible electronic devices is further revealed by fabricating DN ionogel strain sensors to detect the movement of different human limbs including the bending of the finger, wrist, and elbow as well as the slight throat jitter during the swallowing and vocalization, showing fast response, high sensitivity, and good repeatability.
As a new two-dimensional material similar to graphene,
MXene has
attracted extensive attention in the field of electrochemical materials
such as supercapacitors because of its excellent mechanical properties,
electrical conductivity, and thermal conductivity. What is better
than graphene is that the few-layer MXene material obtained by proper
treatment has good water dispersibility and can be used as an ideal
nanomaterial to enhance the conductivity of hydrogels. However, the
articles about the few-layer MXene material used in the preparation
of composite hydrogels are rare. In this paper, MXene was synthesized
by Yury mild method. Poly(N-isopropyl acrylamide)
(PNIPAM) hydrogel and physical cross-linking hydrogel were used as
the matrix to prepare composite hydrogels with temperature sensitivity
and stress-sensing properties. The composite hydrogels exhibited excellent
mechanical properties: it could be stretched to over 14 times the
original length and achieved a 0.4 MPa tensile strength while showing
good self-healing ability, which was of great significance for the
practical application of hydrogels. The conductivity of the composite
hydrogel was 1.092 S/m, which was about 15 times that of the control
hydrogel without MXene. The potential of the composite hydrogel as
a smart compression sensor was also verified by the conductivity tests.
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