Inhibition of tumor growth in CT-26 colorectal cancer-bearing mice with alcoholic extracts of Curcuma longa and Rosmarinus officinalis

Makaremi, Shima; Ganji, Ali; Ghazavi, Ali; Mosayebi, Ghasem

doi:10.1016/j.genrep.2020.101006

Cited by 12 publications

(10 citation statements)

References 30 publications

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“…T A B L E 2 In vitro and in vivo studies on upregulation of M1 macrophage polarization and their related pathways by herbal compounds Makaremi, Ganji, Ghazavi, & Mosayebi, 2021). Its dendrosome form increases the aqueous solubility of this hydrophobic substance and increases the bioavailability of curcumin.…”

Section: Natural Compounds That Upregulate M1 Polarizationmentioning

confidence: 99%

“…Curcumin is a polyphenol compound extracted from the plant Curcuma longa with anticancer activity (Maizura, Aminah, & Wan Aida, 2011; Makaremi, Ganji, Ghazavi, & Mosayebi, 2021). Its dendrosome form increases the aqueous solubility of this hydrophobic substance and increases the bioavailability of curcumin.…”

Section: Natural Compounds That Upregulate M1 Polarizationmentioning

confidence: 99%

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Macrophage polarization by phytotherapy in the tumor microenvironment

Saeedifar

Mosayebi

Ghazavi

et al. 2021

Phytotherapy Research

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Several signaling pathways were involved in M1 (classic) and M2 (alternative) macrophage polarization. Disruption of M2-related signaling pathways and improvement of M1-related signaling pathways can be identified as one of the cancer therapeutic approaches. Prevention of macrophage differentiation into M2 by different herbal agents with antitumor properties can be considered as a promising therapeutic target for cancer patients. In the present review study, we investigated the effect of herbal compounds on M1 and M2 related signaling pathways to reduce M2 and increase M1 macrophage polarization for the treatment of different types of cancer.

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Section: Natural Compounds That Upregulate M1 Polarizationmentioning

confidence: 99%

Section: Natural Compounds That Upregulate M1 Polarizationmentioning

confidence: 99%

Macrophage polarization by phytotherapy in the tumor microenvironment

Saeedifar

Mosayebi

Ghazavi

et al. 2021

Phytotherapy Research

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“…Some studies confirm that rosemary has antimicrobial properties [19], anti-breast-colorectal-prostate cancer [20][21][22], antioxidant properties [23] and even it is known as a memory herb [24]. This spice is composed of hydroxybenzoic acid, hydroxycinnamic acid, triterpenic acid, flavonoids, Elena M. Gómez-Sáez, Gonzalo L. Alonso and Herminia Vergara contributed equally to this work.…”

Section: Introductionmentioning

confidence: 99%

Effect of rosemary addition on the sensorial and physicochemical qualities of dry-cured ham slices. Measurement of camphor transfer

Gómez-Sáez

Alonso

Vergara

2023

Eur Food Res Technol

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This study determined the effect of three concentrations (R1: high, R2: medium and R3: low) of rosemary added to dry-cured ham slices vacuum packaged. pH and the colour parameters were evaluated at 0, 7, 14, 28 and 60 days of storage; visual appearance, odour, flavour and camphor content were assessed at days 7, 14, 28 and 60. The rosemary concentration changed the colour parameters, significantly altering the visual appearance (p < 0.001 at 7 and 14 days; p < 0.5 at day 28), but did not affect the pH, neither odour nor flavour. Nevertheless, significant differences were found with the time on R1 and R2 in odour (p < 0.01 and p < 0.001, respectively) and in flavour (p < 0.001). Camphor content was similar in all samples but changed over the time in R1 (p < 0.001) and R2 (p < 0.01). In conclusion, despite the differences observed, it is evident that the addition of this spice was to the liking of the panellists, in any of the concentrations used.

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“…C. longa is frequently used as a medicinal herb and a food supplement owing to its health benefits. C. longa is known for many biological activities, among which anticancer activity has been reported, including against glioma cancer [3], cervical cancer [3], prostate cancer [3,4], oral cancer [4], breast cancer [5,6], colon cancer [7], and liver cancer [8] in vitro, and liver cancer [9], colon cancer [10], and breast cancer [11] in vivo.…”

Section: Introductionmentioning

confidence: 99%

Metabolomics reveals that Curcuma longa and demethoxycurcumin inhibit HCT116 human colon cancer cell growth

Yoon,

Choi,

Shin

et al. 2023

Appl Biol Chem

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Studies on the use of natural products to treat cancer are ongoing, and turmeric (Curcuma longa L.), a medicinal crop, is known for various effects including anticancer activity. In this study, the inhibitory effect of C. longa and demethoxycurcumin on cancer cell growth in a colorectal cancer cell line (HCT116) was investigated by using nuclear magnetic resonance (NMR) spectroscopy-based metabolomics. For this analysis, HCT116 cells were treated with doxorubicin (positive control), C. longa extract, or demethoxycurcumin (20, 40, and 60 μM). In the NMR spectra of the HCT116 cell extract, 45 metabolites were identified and quantified. The quantified metabolites were analyzed by biomarker analysis, and significantly changed metabolites were filtered by the area under the curve (AUC) of the receiver operator characteristic (ROC) curve. Multivariate statistical analysis of NMR spectra was conducted to confirm the distribution among groups. Through an S-line plot, it was possible to identify metabolites that contributed to the differences seen in the OPLS-DA score plot. Taken together, the results reveal that C. longa extract induces oxidative stress and changes the energy metabolism in HCT116 cells, and that demethoxycurcumin inhibits the energy metabolism strategy for the survival of cancer cells, escape from immune cells, and cancer cell proliferation, thereby enabling the survival of HCT116 cells.

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Inhibition of tumor growth in CT-26 colorectal cancer-bearing mice with alcoholic extracts of Curcuma longa and Rosmarinus officinalis

Cited by 12 publications

References 30 publications

Macrophage polarization by phytotherapy in the tumor microenvironment

Macrophage polarization by phytotherapy in the tumor microenvironment

Effect of rosemary addition on the sensorial and physicochemical qualities of dry-cured ham slices. Measurement of camphor transfer

Metabolomics reveals that Curcuma longa and demethoxycurcumin inhibit HCT116 human colon cancer cell growth

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