Macrophage polarization by phytotherapy in the tumor microenvironment

Saeedifar, Amir Mohammad; Mosayebi, Ghasem; Ghazavi, Ali; Bushehri, Rouhollah Hemmati; Ganji, Ali

doi:10.1002/ptr.7058

Cited by 10 publications

(5 citation statements)

References 111 publications

(133 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Studies have shown that medicinal herbs and their derivatives produce anti-cancer effects by regulating the polarization of macrophages in the tumor microenvironment. 24,25 Our data showed that CRAE inhibited tumor growth in myeloma xenograft model and had a good combined therapeutic effect with bortezomib. Through a series of studies, we proved that CRAE could increase the expression of M1-specific indicators in tumor microenvironment and confirmed the activation of TLR4-NF-κB pathway was the main internal mechanism of CRAE mediated macrophage remodeling to inhibit the growth of myeloma.…”

Section: Discussionmentioning

confidence: 77%

Aqueous Extract of Cimicifuga dahurica Reprogramming Macrophage Polarization by Activating TLR4-NF-κB Signaling Pathway

Qian¹,

Han²,

Sha³

et al. 2022

JIR

View full text Add to dashboard Cite

Cimicifuga dahurica (C. dahurica), which has been used in traditional oriental medicine for a long period, was reported to exert extensive antitumor activity, but the effect and molecular biological mechanism of C. dahurica on multiple myeloma (MM) has not been elaborated. Tumor-associated macrophages (TAMs) exhibit a sustained polarization between tumor killing M1 subtype and tumor supporting M2 subtype. And a lower ratio of M1/M2 is associated with tumor angiogenesis, proliferation and invasion. We explored the inhibitory effect of the aqueous extract of the root of C. dahurica (CRAE) on tumor growth by reprogramming macrophage polarization in the tumor microenvironment. Methods: Mice bearing SP2/0 multiple myeloma were treated with CRAE. Western blotting (WB), immunohistochemistry (IHC) and immunofluorescence staining were utilized to assess tumor growth and TAM populations. Macrophages were depleted by injection of clodronate liposomes to determine and measure the role of CRAE as an anti-tumor agent by targeting macrophages. To simulate tumor microenvironment, MM cells H929 and TAMs were co-cultured using the transwell co-culture system. By using CRAE as an immunoregulator in M2-like macrophages, we analyzed CRAE-treated macrophage-associated surface markers and cytokines by flow cytometry and WB. Results: The results indicated that CRAE treatment could reduce tumor burden of MM mice and a high degree of M1-like macrophages infiltration was detected in tumor tissues. In vitro co-culture system, CRAE significantly promoted the polarization of M2 to M1 phenotype, which led to the increase in apoptosis of myeloma cells. It was found that the M1 polarization induced by CRAE depended on the TLR4-MyD88-TAK1-NF-κB signal transduction. Conclusion:This study elucidated the anticancer mechanism of the aqueous extract of C. dahurica (CRAE) through reprogramming macrophage polarization and highlighted that CRAE could act as a potential novel option for cancer immunotherapy.

show abstract

Section: Discussionmentioning

confidence: 77%

Aqueous Extract of Cimicifuga dahurica Reprogramming Macrophage Polarization by Activating TLR4-NF-κB Signaling Pathway

Qian¹,

Han²,

Sha³

et al. 2022

JIR

View full text Add to dashboard Cite

show abstract

“…This resulted in a reduction in CD206 expression and a decrease in the expression of genes related to M2 polarization. Furthermore, Astragaloside IV impeded the invasion, migration, and angiogenesis induced by M2-conditioned media in A549 and H1299 cells ( Saeedifar et al, 2021 ). Moreover, Astragaloside IV treatment led to a reduction in the number of M2 macrophages present in tumor tissues ( Xu et al, 2018 ).…”

Section: Innate Immunitymentioning

confidence: 99%

Investigating the immune mechanism of natural products in the treatment of lung cancer

Yang,

Chen,

Liu

et al. 2024

Front. Pharmacol.

View full text Add to dashboard Cite

With the deepening of people’s understanding of lung cancer, the research of lung cancer immunotherapy has gradually become the focus of attention. As we all know, the treatment of many diseases relies on the rich sources, complex and varied compositions and wide range of unique biological properties of natural products. Studies have shown that natural products can exert anticancer effects by inducing tumor cell death, inhibiting tumor cell proliferation, and enhancing tumor cell autophagy. More notably, natural products can adjust and strengthen the body’s immune response, which includes enhancing the function of NK cells and promoting the differentiation and proliferation of T lymphocytes. In addition, these natural products may enhance their anticancer effects by affecting inhibitory factors in the immune system, hormone levels, enzymes involved in biotransformation, and modulating other factors in the tumor microenvironment. The importance of natural products in lung cancer immunotherapy should not be underestimated. However, the specific links and correlations between natural products and lung cancer immunity are not clear enough, and further studies are urgently needed to clarify the relationship between the two. In this paper, we will focus on the correlation between natural products and lung cancer immune responses, with a view to providing new research perspectives for immunotherapy of lung cancer.

show abstract

“…Macrophages are crucial to tumor development and at present, some compounds with the ability of regulating macrophage polarization and recruitment to tumor sites have been found (Saeedifar et al, 2021). Many extracts of traditional Chinese medicine have been reported to have anti-tumor effects, some of which can regulate the polarization of macrophages.…”

Section: Natural Products Targeting Macrophages In Tmementioning

confidence: 99%

Natural products targeting macrophages in tumor microenvironment are a source of potential antitumor agents

Liu

Chen

et al. 2023

Phytomedicine

View full text Add to dashboard Cite

Macrophage polarization by phytotherapy in the tumor microenvironment

Cited by 10 publications

References 111 publications

Aqueous Extract of Cimicifuga dahurica Reprogramming Macrophage Polarization by Activating TLR4-NF-κB Signaling Pathway

Aqueous Extract of Cimicifuga dahurica Reprogramming Macrophage Polarization by Activating TLR4-NF-κB Signaling Pathway

Investigating the immune mechanism of natural products in the treatment of lung cancer

Natural products targeting macrophages in tumor microenvironment are a source of potential antitumor agents

Contact Info

Product

Resources

About