Inhibition of monoamine oxidase (MAO) by β-carbolines and their interactions in live neuronal (PC12) and liver (HuH-7 and MH1C1) cells

Respiratory toxicity of cyanobacterial aphantoxins from Aphanizomenon flos-aquae DC-1 in the zebrafish gill

“…The present investigation demonstrated that aphantoxins inhibit MAO activity, suggesting that these toxins may impair monoaminergic conduction in the gills of zebrafish. These results are in agreement with previous studies (Santillo et al, 2014).…”

Harmine stimulates neurogenesis of human neural cells in vitro

“…Harmine has been described as an inhibitor of MAO and DYRK1A 18,19 . MAO inhibition increases serotonergic neurotransmission in the adult brain, which is a key component of the classical antidepressant action.…”

Inhibition of monoamine oxidase (MAO) by α-ethylphenethylamine and N,α-diethylphenethylamine, two compounds related to dietary supplements

“…Additive or synergistic MAO inhibition (Santillo et al, 2014) might result from concurrent ingestion of ethylphenethylamines with other MAO inhibitors including drugs (Youdim et al, 2006) and β-carboline alkaloids in tobacco and botanicals (Dhawan et al, 2004;Fowler et al, 2003;Herraiz et al, 2010;McKenna et al, 1984). Furthermore, in a recent high-throughput screening campaign of 976 compounds (Sipes et al, 2013), MAO A was one of the most promiscuous targets among a total of 331 targets evaluated, which illustrates a potential for inhibition by a variety of less studied compounds.…”