Respiratory toxicity of cyanobacterial aphantoxins from Aphanizomenon flos-aquae DC-1 in the zebrafish gill

Zhang, De Lu; Liu, Si Yi; Zhang, Jing; Zhang, Jian Kun; Hu, Chun Xiang; Liu, Yong Ding

doi:10.1016/j.aquatox.2016.04.014

Cited by 11 publications

(2 citation statements)

References 59 publications

(69 reference statements)

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“…They found the multivalency and α(2–6) exhibited broad biodistribution . By using sialyl-Lewis X conjugated QDs, Ohyanagi et al showed that α(2–3) sialylated nanoparticles appeared to have broad biodistribution at initial hours and was later sequestered in the liver. − Thus, the majority of the mice results seem to be comparable to literature results and the zebrafish results can be considered a suitable alternative to the mouse model.…”

Section: Resultsmentioning

confidence: 74%

Imaging and Targeting of the α(2–6) and α(2–3) Linked Sialic Acid Quantum Dots in Zebrafish and Mouse Models

Yadav

Chaudhary

Subramani

et al. 2018

ACS Appl. Mater. Interfaces

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Sialic acid-conjugated nanocarriers have emerged as attractive biomarkers with promising biomedical applications. The translation of these nanocarriers into clinical applications requires in-depth assessment in animal models. However, due to the complexity, ethical concerns, and cost of the high-order animal system, there is an immediate need of information-rich simple animal models to decipher the biological significance. Herein, we performed in vivo head-to-head comparison of Neu5Acα(2-6) and α(2-3)Gal conjugated quantum dots (QDs) toxicity, biodistribution, and sequestration in wild-type zebrafish ( Danio rerio) and mouse model (C57BL). The fluorescent properties and cadmium composition of quantum dots were used to map the blood clearance, biodistribution, and sequestration of the sialylated QDs in major organs of both models. We observed that α(2-6) sialylated QDs preferentially have prolonged circulating half-life and broader biodistribution in both models. On the contrary, α(2-3) sialic acid and galactose-conjugated QDs have shortened blood circulation time and are sequestered in the liver, and cleared after several hours in both models. These results demonstrate the applicability of the zebrafish and sialylated QDs to target specific organs, as well as drug delivery and biomedical diagnostics.

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Section: Resultsmentioning

confidence: 74%

Imaging and Targeting of the α(2–6) and α(2–3) Linked Sialic Acid Quantum Dots in Zebrafish and Mouse Models

Yadav

Chaudhary

Subramani

et al. 2018

ACS Appl. Mater. Interfaces

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“…De Smet & Blust [268] explicaron que altos niveles de transaminasas en las branquias de peces están asociados a un aumento de la descomposición de proteínas, lo que sugiere una respuesta funcional para compensar los gastos energéticos extras en situaciones de estrés. Experiencias reportadas con D. rerio y C. carpio expuestos a diferentes tipos de contaminantes demostraron un aumento en la actividad de ambas enzimas (AST y ALT), lo cual fue asociado con daños a nivel funcional y estructural de las branquias [269], [270].…”

Section: Enzimas Transaminasas En Branquiasunclassified

Nanosilver toxicity in gills of a neotropical fish: Metal accumulation, oxidative stress, histopathology and other physiological effects

Ale

Bacchetta

Rossi

et al. 2018

Ecotoxicology and Environmental Safety

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ACAP: antioxidant capacity againt peroxiles radicals, capacidad antioxidante contra radicales peroxilos ACP: análisis de componentes principales AgNP: nanopartículas de plata AH: ácidos húmicos ALT: alanino-aminotransferasa AST: aspartato-aminotransferasa CAT: catalasa CL 50 : concentración letal 50 CM: células mucosas CMHC: concentración media de hemoglobina corpuscular Col: colesterol DI: distancia interlamelar DML: desestabilización de la membrana lisosomal EDS: energy dispersive spectroscopy, análisis de energía dispersiva EEP: espesor del epitelio basal ELS: espesor de laminillas secundarias FC: factor de condición Gla: glucosa GlB: glóbulos blancos Glo: glucógeno GlR: glóbulos rojos GPx: glutatión peroxidasa GR: glutatión reductasa GSH: glutatión reducido GSSG: glutatión oxidado GST: glutatión S-transferasa Hb: hemoglobina HCM: hemoglobina corpuscular media Ht: hematocrito IHS: índice hepato-somático I org : índice del órgano I pr : índice del patrón de reacción LE: longitud estándar LLS: longitud de laminillas secundarias LPO: lipid peroxidation, peroxidación lipídica LT: longitud total MN: micronúcleos MT: metalotioneínas NM(s): nanomaterial(es) NP(s): nanopartícula(s)

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Effects of fermented Aphanizomenon flos-aquae on the caecal microbiome of mice fed a high-sucrose and low-dietary fibre diet

et al. 2020

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Respiratory toxicity of cyanobacterial aphantoxins from Aphanizomenon flos-aquae DC-1 in the zebrafish gill

Cited by 11 publications

References 59 publications

Imaging and Targeting of the α(2–6) and α(2–3) Linked Sialic Acid Quantum Dots in Zebrafish and Mouse Models

Imaging and Targeting of the α(2–6) and α(2–3) Linked Sialic Acid Quantum Dots in Zebrafish and Mouse Models

Nanosilver toxicity in gills of a neotropical fish: Metal accumulation, oxidative stress, histopathology and other physiological effects

Effects of fermented Aphanizomenon flos-aquae on the caecal microbiome of mice fed a high-sucrose and low-dietary fibre diet

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