Nanosilver toxicity in gills of a neotropical fish: Metal accumulation, oxidative stress, histopathology and other physiological effects

Ale, Analía; Bacchetta, Carla; Rossi, Andrea; Galdopórpora, Juan Manuel; Desimone, Martín Federico; Torre, Fernando R. de la; Gervasio, Susana Graciela; Cazenave, Jimena

doi:10.1016/j.ecoenv.2017.11.072

Cited by 63 publications

(18 citation statements)

References 225 publications

(375 reference statements)

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“…AgNPs of certain concentrations about over 10 μg/mL have significant toxic effects on the proliferation of mammalian cells, such as human blood mononuclear cells [12], mesenchymal stem cells [13], human bronchial epithelial (BEAS-2B) cells [14], mouse vascular endothelial cells [15], spermatogonial stem cells [16], mouse embryonic fibroblast cell line and human breast carcinoma cell line [17]. AgNPs are also toxic to many species including HIV-1 [18], fish [19–21], rabbit [22], halophilic microalgae [23], green freshwater algae [24], and Arabidopsis [25].…”

Section: Introductionmentioning

confidence: 99%

Comparative study on the toxic mechanisms of medical nanosilver and silver ions on the antioxidant system of erythrocytes: from the aspects of antioxidant enzyme activities and molecular interaction mechanisms

Fang

Chi

et al. 2019

J Nanobiotechnol

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Background The wide application of silver nanoparticles (AgNPs) in medicals and daily utensils increases the risk of human exposure. The study on cell and protein changes induced by medical AgNPs (20 nm) and Ag + gave insights into the toxicity mechanisms of them. Results AgNPs and Ag + affected the enzymatic and non-enzymatic antioxidant systems of red blood cells (RBCs). When RBCs were exposed to AgNPs or Ag + (0–0.24 μg/mL), catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPX) were more sensitive to Ag + , whereas the RBCs had slightly higher glutathione (GSH) contents treated by AgNPs. Both AgNPs and Ag + increased the malondialdehyde (MDA) content of RBCs, but the difference was not significant. The difference in the change of the enzyme activity indicated that AgNPs and Ag + have different influencing mechanisms on CAT and GPX. And SOD has stronger resistance to both of AgNPs and Ag + . When AgNPs or Ag + (0–10 μg/mL) was directly applied on enzymatic proteins, although AgNPs or Ag + at a high concentration was toxic, at the concentration below 0.4 μg/mL could promote the activities of CAT/SOD/GPX. The spectroscopic results (fluorescence, synchronous fluorescence, resonance light scattering and ultraviolet absorption), including the changes in amino acid microenvironment, peptide chain conformation, and aggregation state, indicated that the interaction mechanism and conformational changes were also the important factors for the changes in the activities of SOD/CAT when SOD/CAT were directly exposed to AgNPs or Ag + . Conclusions Low concentration (< 0.4 μg/mL) of AgNPs is relatively safe and the direct effects of AgNPs and Ag + on enzymes are important reasons for the change in antioxidant capacity of RBCs.

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Section: Introductionmentioning

confidence: 99%

Comparative study on the toxic mechanisms of medical nanosilver and silver ions on the antioxidant system of erythrocytes: from the aspects of antioxidant enzyme activities and molecular interaction mechanisms

Fang

Chi

et al. 2019

J Nanobiotechnol

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“…Anyway, it has been shown that AgNPs can cause acute toxicity ( Griffitt et al, 2008 ) and, mainly, a wide range of sublethal damages in fish. Interestingly, AgNPs provoked changes in the beneficial microbial community living on both skin and intestinal mucus, which constitutes the first barrier and immunological defence of fish ( Merrifield et al, 2013 ; Bacchetta et al, 2016 ; Ale et al, 2018a ). To counteract the effects of AgNPs, an increase in the number of mucus cells in the gills of Cyprinus carpio and Prochilodus lineatus has been recorded ( Lee et al, 2012 ; Ale et al, 2018a ).…”

Section: Aquatic Ecotoxicity Of Silver Nanoparticlesmentioning

confidence: 99%

“…Undoubtedly, oxidative stress is the most studied mechanism for explaining AgNP toxicity. Exposure to AgNPs commonly results in the overproduction of ROS, the activation of the antioxidant system, the increase of lipid peroxidation, and membrane damage, which lead to apoptosis and loss of cellular functions ( Chae et al, 2009 ; Lee et al, 2012 ; Massarsky et al, 2014 ; Valerio-García et al, 2017 ; Ale et al, 2018a ; Ale et al, 2018b ; Khan et al, 2018 ). On the other hand, some studies have demonstrated that AgNPs can reach the cell nucleus, inducing DNA damage and nuclear abnormalities ( Sayed, 2016 ; Bacchetta et al, 2017 ; Sayed and Soliman, 2017 ).…”

Section: Aquatic Ecotoxicity Of Silver Nanoparticlesmentioning

confidence: 99%

“…In addition to cellular, subcellular, and molecular effects, the toxicity of AgNPs has been demonstrated at multiple levels on different toxic endpoints, such as diverse physiological processes (e.g., metabolic pathways, ion regulation, and respiratory system) ( Bilberg et al, 2012 ; Massarsky et al, 2014 ; Valerio-García et al, 2017 ; Ale et al, 2018b ; Khan et al, 2018 ), organ histopathology ( Govindasamy and Rahuman, 2012 ; Lee et al, 2012 ; Rajkumar et al, 2016 ; Ale et al, 2018a ; Khan et al, 2018 ), neurotoxicity and behavioural alterations ( Powers et al, 2011 ), and embryotoxicity and teratogenic effects ( Yoo et al, 2016 ; Pereira et al, 2019 ).…”

Section: Aquatic Ecotoxicity Of Silver Nanoparticlesmentioning

confidence: 99%

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Building the Bridge From Aquatic Nanotoxicology to Safety by Design Silver Nanoparticles

Corsi

Desimone

Cazenave

2022

Front. Bioeng. Biotechnol.

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Nanotechnologies have rapidly grown, and they are considered the new industrial revolution. However, the augmented production and wide applications of engineered nanomaterials (ENMs) and nanoparticles (NPs) inevitably lead to environmental exposure with consequences on human and environmental health. Engineered nanomaterial and nanoparticle (ENM/P) effects on humans and the environment are complex and largely depend on the interplay between their peculiar properties such as size, shape, coating, surface charge, and degree of agglomeration or aggregation and those of the receiving media/body. These rebounds on ENM/P safety and newly developed concepts such as the safety by design are gaining importance in the field of sustainable nanotechnologies. This article aims to review the critical characteristics of the ENM/Ps that need to be addressed in the safe by design process to develop ENM/Ps with the ablility to reduce/minimize any potential toxicological risks for living beings associated with their exposure. Specifically, we focused on silver nanoparticles (AgNPs) due to an increasing number of nanoproducts containing AgNPs, as well as an increasing knowledge about these nanomaterials (NMs) and their effects. We review the ecotoxicological effects documented on freshwater and marine species that demonstrate the importance of the relationship between the ENM/P design and their biological outcomes in terms of environmental safety.

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“…They are the major site of uptake for most water bone toxicants and site of toxic impact for many of them. (Ale et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Toxicity induced alterations as biomarker of environmental pollution

Kuar¹,

Kaur²

2019

Contaminants in Agriculture and Environment: Health Risks and Remediation

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Over the past few decades dye contamination of aquatic systems has attracted the attention of several investigators both in the developed and developing countries of the world. A large quantity of these dyes enters aquatic bodies from time to time because a substantial amount of a dye (10-15% unbound dyes) is lost in the effluent during dyeing processes. In return the aquatic bodies end up being the final destination of a large quantity of wastes from these sectors. Waste waters from dye manufacturing, paper, leather and textile industries bring tons of dyes into the aquifers, most of which are highly toxic to the flora and fauna of the receiving water bodies. Scanning electron microscopic observations were made for the changes in the surface ultra morphology of gills of Cirrhinus mrigala on exposure to lethal (0.1, 0.2, 0.4, 0.6 and 0.8 mg/L dye) doses of Basic Violet-1 (an important textile and hair colorant; CI: 42535, Trade name-Methyl Violet-2B). Present study was taken up as insufficient data exist regarding safety of this dye. The dye was observed to be cytotoxic in nature during the acute (96h) exposure to lethal doses. The dye caused reduction or complete loss of microridges, increase in mucous openings and Chapter contents Introduction …………………………………………………………………………………………………….. degeneration of gill lamellae and rakers. Therefore, time to time monitoring of ultra morphology of tissues will provide us early indicators for the stress of very low levels of pollutants which may later cause mortality of the fish. The study holds importance because fishes are an important link in the food chain of man, respond to toxicants in a manner similar to higher vertebrates causing serious diseases.

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Nanosilver toxicity in gills of a neotropical fish: Metal accumulation, oxidative stress, histopathology and other physiological effects

Cited by 63 publications

References 225 publications

Comparative study on the toxic mechanisms of medical nanosilver and silver ions on the antioxidant system of erythrocytes: from the aspects of antioxidant enzyme activities and molecular interaction mechanisms

Comparative study on the toxic mechanisms of medical nanosilver and silver ions on the antioxidant system of erythrocytes: from the aspects of antioxidant enzyme activities and molecular interaction mechanisms

Building the Bridge From Aquatic Nanotoxicology to Safety by Design Silver Nanoparticles

Toxicity induced alterations as biomarker of environmental pollution

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