Inhibition of IL-1<b>β</b> Improves Fatigue in Type 2 Diabetes

Cavelti-Weder, Claudia; Furrer, R; Keller, Cornelia; Brun, Reto; Solinger, Alan M.; Gast, Heidemarie; Fontana, Adriano; Donath, Marc Y.; Penner, Iris‐Katharina

doi:10.2337/dc11-1196

Cited by 58 publications

(45 citation statements)

References 4 publications

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“…Gevokizumab inhibits both the binding of IL-1β to IL-1RI and the subsequent recruitment of IL-1 accessory protein, primarily by reducing the association rates of these interactions; as such, it is a unique inhibitor of IL-1β signaling (110). Initial studies with this monoclonal antibody have been in the treatment of type 2 diabetes (99,112) and Behçet disease (113).…”

Section: Safety Of Il-1 Inhibitorsmentioning

confidence: 99%

Evasion of inflammasome activation by microbial pathogens

Ulland¹,

Ferguson²,

Sutterwala³

2015

J. Clin. Invest.

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Section: Safety Of Il-1 Inhibitorsmentioning

confidence: 99%

Evasion of inflammasome activation by microbial pathogens

Ulland¹,

Ferguson²,

Sutterwala³

2015

J. Clin. Invest.

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“…Increased levels of circulating inflammatory markers were found to be significantly more prominent in patients with type 2 diabetes [7][8][9][10] . Systemic inflammation in type 2 diabetes is believed to originate, at least partially, from the adipose tissue [11][12][13][14] .…”

Section: Introductionmentioning

confidence: 97%

Aerobic exercises alleviate symptoms of fatigue related to inflammatory cytokines in obese patients with type 2 diabetes.

2016

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Background: Non-insulin dependent diabetic patients frequently suffer from fatigue symptoms that result from chronic systemic inflammation. Aerobic exercise was proved to modulate systemic inflammation. Objective: This study was an attempt to measure the impact of aerobic exercises on fatigue symptoms related to systemic inflammation in obese patients with type 2 diabetes. Methods: Eighty obese patients with type 2 diabetes participated in the present study, their age ranged from 40-58 years and their BMI ranged from 31-36 kg/m 2 and were assigned to two subgroups; group (A) received aerobic exercise training for 12 weeks and group (B) received no exercise training for 3 months. Measurements of fatigue symptoms and markers of systemic inflammation were assessed before and at the end of the study for all participants in both groups. Results:The mean values of inflammatory markers (IL-6 and TNF-α) and Multidimensional Fatigue Inventory (MFI) was significantly decreased in group (A), while changes were not significant in group (B). Moreover, there were significant differences between mean levels of the investigated parameters in group (A) and group (B) at the end of the study. Sci. 2015;15(4):1142-8. http://dx.doi.org/10.4314/ahs.v15i4.13 Conclusion

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“…3,10 Fritschi and Quinn recently provided a detailed review of the correlates of fatigue in diabetes, including conflicting findings regarding the relationship between fatigue and glycemic control. 8 Type 2 diabetes is a disorder associated with chronic low-grade inflammation.…”

mentioning

confidence: 99%

Fatigue in Adults with Type 2 Diabetes—An Overview of Current Understanding and Management Approaches

Fritschi¹,

Fink²

2012

US Endocrinology

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Patients with type 2 diabetes often experience fatigue, which impacts their self-care and quality of life. There are few data supporting a relationship between fatigue and glucose homeostasis, but fatigue in type 2 diabetes has been associated with higher body mass index (BMI), depression, physical inactivity, sleep disturbances, and chronic low-grade inflammation. Although links between fatigue and inflammation are documented in other disease populations, little is known about inflammatory mechanisms specific to type 2 diabetes and associated treatment modalities for type 2 diabetes-related fatigue. Herein we review existing knowledge about fatigue in type 2 diabetes and potential pharmacologic and behavioral therapies.

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Inhibition of IL-1β Improves Fatigue in Type 2 Diabetes

Cited by 58 publications

References 4 publications

Evasion of inflammasome activation by microbial pathogens

Evasion of inflammasome activation by microbial pathogens

Aerobic exercises alleviate symptoms of fatigue related to inflammatory cytokines in obese patients with type 2 diabetes.

Fatigue in Adults with Type 2 Diabetes—An Overview of Current Understanding and Management Approaches

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